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The map label for this gene is folP [H]

Identifier: 117919473

GI number: 117919473

Start: 1196220

End: 1197053

Strand: Direct

Name: folP [H]

Synonym: Shewana3_1024

Alternate gene names: 117919473

Gene position: 1196220-1197053 (Clockwise)

Preceding gene: 117919472

Following gene: 117919474

Centisome position: 24.06

GC content: 50.96

Gene sequence:

>834_bases
GTGTTTGAATTAATTGCTGGAACCAAACGCTTATCCTTAGCCTCGCCCGTCGTGATGGGCATTCTGAATGTTACTCCCGA
TTCTTTTTCCGATGGTGGAAAGTTCTCTTCCTTTGAATTAGCTTGCCAACATGCCGATGAGATGGTCGCCCAAGGGGCGC
TTATCATCGATATCGGTGGCGAGTCGACAAGACCGGGCGCGGCCGATGTGTCGGTTCAAGATGAACTCGCACGGGTGATC
CCTTTGGTGGAATATGTCGCGAAACACCATGATGTGTGGATTTCGGTCGATACCAGTAAACCGGAAGTGATGCGACAAGC
GGTGAATGCTGGCGCCCATTTAATCAACGATGTGCGTGCCTTGTTGGAGCCTGGGGCTTTAGAGACTGCGGCGCAGCTAA
ATGTGCCCATCTGTTTGATGCACATGCAGGGCGCACCGCGCAGTATGCAAACGGCGCCCGAATACCAAGACCTTGTTGCC
GATGTTTCTGAGTTTTTGTACGAGCGTATTCAAGCCTGCATCGATGCGGGGATCCCGCGGGAGCGATTGTTAATCGACCC
GGGTTTTGGCTTTGGTAAAACCTTAGAACACAACTATGAACTGCTGGCGAAGTTAGATAGTTTTGAGCAGTTTGAACTGC
CGATATTGATAGGTTTATCCCGTAAGAGCATGATAGGAAACCTCCTTGCTAGACCGACCTCCGAGCGTTTAGCGGGGAGC
CTTGCTGGCGCCATGATAGCGGCCCAGAAAGGGGCACATATCATTCGTGTCCATGATGTCCCTGAAACTGTCGATATGCT
GAAAGTGTTACAAGCGACACAGGCATATCTATAA

Upstream 100 bases:

>100_bases
AATTGACTGCGCTGTCATTCAATATAAATCAGTCACATGAGTGAAAAGCGCAGAAAACGGATGAAGCGCGCTAGCAAGCT
GTCCCAAATGGAGTCAATGC

Downstream 100 bases:

>100_bases
AGGCTATTTTTGTTAAGTATTTCATTAATATTATGATCCCAACCGAAGGGACACATTGAAGTTTGTGGGGCAATATGAGC
GAACGTAAATTTTTTGGAAC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MFELIAGTKRLSLASPVVMGILNVTPDSFSDGGKFSSFELACQHADEMVAQGALIIDIGGESTRPGAADVSVQDELARVI
PLVEYVAKHHDVWISVDTSKPEVMRQAVNAGAHLINDVRALLEPGALETAAQLNVPICLMHMQGAPRSMQTAPEYQDLVA
DVSEFLYERIQACIDAGIPRERLLIDPGFGFGKTLEHNYELLAKLDSFEQFELPILIGLSRKSMIGNLLARPTSERLAGS
LAGAMIAAQKGAHIIRVHDVPETVDMLKVLQATQAYL

Sequences:

>Translated_277_residues
MFELIAGTKRLSLASPVVMGILNVTPDSFSDGGKFSSFELACQHADEMVAQGALIIDIGGESTRPGAADVSVQDELARVI
PLVEYVAKHHDVWISVDTSKPEVMRQAVNAGAHLINDVRALLEPGALETAAQLNVPICLMHMQGAPRSMQTAPEYQDLVA
DVSEFLYERIQACIDAGIPRERLLIDPGFGFGKTLEHNYELLAKLDSFEQFELPILIGLSRKSMIGNLLARPTSERLAGS
LAGAMIAAQKGAHIIRVHDVPETVDMLKVLQATQAYL
>Mature_277_residues
MFELIAGTKRLSLASPVVMGILNVTPDSFSDGGKFSSFELACQHADEMVAQGALIIDIGGESTRPGAADVSVQDELARVI
PLVEYVAKHHDVWISVDTSKPEVMRQAVNAGAHLINDVRALLEPGALETAAQLNVPICLMHMQGAPRSMQTAPEYQDLVA
DVSEFLYERIQACIDAGIPRERLLIDPGFGFGKTLEHNYELLAKLDSFEQFELPILIGLSRKSMIGNLLARPTSERLAGS
LAGAMIAAQKGAHIIRVHDVPETVDMLKVLQATQAYL

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=272, Percent_Identity=61.3970588235294, Blast_Score=352, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6324073, Length=329, Percent_Identity=27.0516717325228, Blast_Score=126, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30012; Mature: 30012

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFELIAGTKRLSLASPVVMGILNVTPDSFSDGGKFSSFELACQHADEMVAQGALIIDIGG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECC
ESTRPGAADVSVQDELARVIPLVEYVAKHHDVWISVDTSKPEVMRQAVNAGAHLINDVRA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
LLEPGALETAAQLNVPICLMHMQGAPRSMQTAPEYQDLVADVSEFLYERIQACIDAGIPR
HHCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
ERLLIDPGFGFGKTLEHNYELLAKLDSFEQFELPILIGLSRKSMIGNLLARPTSERLAGS
HHEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHCCCCHHHHHHH
LAGAMIAAQKGAHIIRVHDVPETVDMLKVLQATQAYL
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFELIAGTKRLSLASPVVMGILNVTPDSFSDGGKFSSFELACQHADEMVAQGALIIDIGG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECC
ESTRPGAADVSVQDELARVIPLVEYVAKHHDVWISVDTSKPEVMRQAVNAGAHLINDVRA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
LLEPGALETAAQLNVPICLMHMQGAPRSMQTAPEYQDLVADVSEFLYERIQACIDAGIPR
HHCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
ERLLIDPGFGFGKTLEHNYELLAKLDSFEQFELPILIGLSRKSMIGNLLARPTSERLAGS
HHEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHCCCCHHHHHHH
LAGAMIAAQKGAHIIRVHDVPETVDMLKVLQATQAYL
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]