Click here to switch to the map view.

The map label for this gene is fhs [H]

Identifier: 117919013

GI number: 117919013

Start: 653188

End: 654900

Strand: Direct

Name: fhs [H]

Synonym: Shewana3_0560

Alternate gene names: 117919013

Gene position: 653188-654900 (Clockwise)

Preceding gene: 117919011

Following gene: 117919015

Centisome position: 13.14

GC content: 53.53

Gene sequence:

>1713_bases
ATGCTAACCGATATGGATATTTCGCGCCGTGCGCACCTAAAAGATATCGCAGCGCTTGGCGCCGAGTTTGGGTTATTGCC
CGATGAGATGCAGCTCTTTGGCAAGACTAAAGCCAAGGTCGATTTACGTGCGCAGCAGCGCTTAGCCGAGCAGCAACAGG
GCAAACTGATCATTGTCACCGCCGTGACACCTACGCCCCACGGCGAAGGCAAAACCGTCACCACCATTGGCTTAACCCAA
TCCCTCAAAGCGCTCGGTAACAAGGTGTGCGCCTGTATTCGACAGCCCAGTATGGGCCCGGTTTTTGGGGTGAAAGGTGG
CGCTGCTGGTGGCGGTTACGCCCAAGTGGTGCCCATGCAGGAGCTGAATCTGCATCTAACGGGTGATATTCATGCCGTCA
GCAGTGCCCATAATCTTGGCGCGGCGGCGATAGCCTCTCGGCTGTACCATGAAACACGTTTAGGCAAGGCCGAATTTGAG
TCGCAGTCTGGGCAGAATTACCTGGATATAGCGCCTAATGGCATCCGTTGGCATAGGGTGGTCGACCATAACGATCGCTG
TTTACGTGAAATAGAGGTTGGGCTGGGTGAAAATAATGGCCCAGCTTACACCTCTGGCTTTGATATTACCGCTGCCTCTG
AGTTAATGGCGATTCTTGCACTCAGTCGTAATCTGGCGGATATGCGCGCGCGTATTGGCAAGCTTGTGCTGGCAGTCAAT
CGTCAAGGTGCGGCTATTAGCGCGGAAGACCTTGGGGTTGCCGGCGCGATGACGGCGATCATGGCGGATGCGGTAAAACC
TACCTTGATGCAGACTTTAAACGGTGCGCCTTGTCTTATCCACGCAGGGCCATTTGCCAATATTGCCCATGGTAACTCGT
CGGTGATTGCCGACGATATCGCCTTAAAATTGGCCGATTTTGTGGTAACGGAAGGTGGTTTTGGCTCCGATATGGGGTTT
GAGAAATTTTGTAATATCAAGGCGCGCCAGTCTGGATTAGCCCCGAGCGCTGCGGTGTTAGTGACCACCTTAAAGGCATT
GAAGGCAAATAGCGGCTTGACGTCGGATGCGGATATCAATGCGCCCGACCAAGCCCGTCTCGAGGCGGGATTTGCCAACT
TAAACTGGCATATCAACAATGTGGCGCGTTACGGTATTCCCGTTGTGGTGGCTATTAATCGCTTTGCAACCGATACGGAT
GCCGAGCTTAACTGGTTGATTGAAGCCGTTGCGGGCACTGCCGCCTTTGGCTGCGAGCTTAGCGAGGCTTTCAGCCAAGG
TGAGGCGGGGGCGCTGACCTTGGCGCAAACCGTCATGCGCGCCTGTGAGCAGCCAAGCGAGTTTACCCTGCTATATCCCG
ATGAAATGGCGCTTGAGGCGAAATTATCGACCTTGGCCGAAGTTGGCTATGGCGCTACTGGGGTGAGTTTATCCGAGGCG
GCTAAGTTGCAATTACAAGAACTCAGTGCCCTTGGCTACGCCGATTTACCCGTCTGCATGGCAAAAACACCCTTATCCAT
TAGCCATGACCCTCAACTTAAAGGCGTACCGCAAGGTTTTATCGTGCCAGTGCGCGAGTTAGTGTTAAATGCTGGAGCCG
GATTTATTACCGCGCTGGTGGGGAATGTGATGACTATGCCGGGACTTGGATTAGTTCCGGGCTATTTAAAGGTTGATATC
GGCGCCGATGGTGAGATTACCGGTTTAGGTTAA

Upstream 100 bases:

>100_bases
ATCAGCCGTTGCTGATACTTACCGATTTTGCATACCTATTTTGTATTTCTTGCTCGCATGCCGAGCGGGGATACCAAAAT
ACCCAAGGGAGAGATGACCC

Downstream 100 bases:

>100_bases
TCGATTAGCAGTTCGAATATCATGAAAAAGGCGCAATCTAGGATTGCGCCTTTTGTTTACTTCTCGCCTTGGCGAAGCGT
TATTTACTGGTTTGGTAAAT

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MLTDMDISRRAHLKDIAALGAEFGLLPDEMQLFGKTKAKVDLRAQQRLAEQQQGKLIIVTAVTPTPHGEGKTVTTIGLTQ
SLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSSAHNLGAAAIASRLYHETRLGKAEFE
SQSGQNYLDIAPNGIRWHRVVDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLADMRARIGKLVLAVN
RQGAAISAEDLGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDIALKLADFVVTEGGFGSDMGF
EKFCNIKARQSGLAPSAAVLVTTLKALKANSGLTSDADINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDTD
AELNWLIEAVAGTAAFGCELSEAFSQGEAGALTLAQTVMRACEQPSEFTLLYPDEMALEAKLSTLAEVGYGATGVSLSEA
AKLQLQELSALGYADLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALVGNVMTMPGLGLVPGYLKVDI
GADGEITGLG

Sequences:

>Translated_570_residues
MLTDMDISRRAHLKDIAALGAEFGLLPDEMQLFGKTKAKVDLRAQQRLAEQQQGKLIIVTAVTPTPHGEGKTVTTIGLTQ
SLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSSAHNLGAAAIASRLYHETRLGKAEFE
SQSGQNYLDIAPNGIRWHRVVDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLADMRARIGKLVLAVN
RQGAAISAEDLGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDIALKLADFVVTEGGFGSDMGF
EKFCNIKARQSGLAPSAAVLVTTLKALKANSGLTSDADINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDTD
AELNWLIEAVAGTAAFGCELSEAFSQGEAGALTLAQTVMRACEQPSEFTLLYPDEMALEAKLSTLAEVGYGATGVSLSEA
AKLQLQELSALGYADLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALVGNVMTMPGLGLVPGYLKVDI
GADGEITGLG
>Mature_570_residues
MLTDMDISRRAHLKDIAALGAEFGLLPDEMQLFGKTKAKVDLRAQQRLAEQQQGKLIIVTAVTPTPHGEGKTVTTIGLTQ
SLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSSAHNLGAAAIASRLYHETRLGKAEFE
SQSGQNYLDIAPNGIRWHRVVDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLADMRARIGKLVLAVN
RQGAAISAEDLGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDIALKLADFVVTEGGFGSDMGF
EKFCNIKARQSGLAPSAAVLVTTLKALKANSGLTSDADINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDTD
AELNWLIEAVAGTAAFGCELSEAFSQGEAGALTLAQTVMRACEQPSEFTLLYPDEMALEAKLSTLAEVGYGATGVSLSEA
AKLQLQELSALGYADLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALVGNVMTMPGLGLVPGYLKVDI
GADGEITGLG

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=617, Percent_Identity=48.2982171799027, Blast_Score=515, Evalue=1e-146,
Organism=Homo sapiens, GI36796743, Length=612, Percent_Identity=45.7516339869281, Blast_Score=484, Evalue=1e-136,
Organism=Homo sapiens, GI310124614, Length=81, Percent_Identity=44.4444444444444, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17568737, Length=620, Percent_Identity=47.258064516129, Blast_Score=510, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17568739, Length=620, Percent_Identity=47.258064516129, Blast_Score=510, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=44.888178913738, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6319558, Length=629, Percent_Identity=42.7662957074722, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24645718, Length=618, Percent_Identity=44.1747572815534, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=618, Percent_Identity=44.1747572815534, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=618, Percent_Identity=44.1747572815534, Blast_Score=467, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45551871, Length=618, Percent_Identity=44.1747572815534, Blast_Score=467, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59644; Mature: 59644

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00721 FTHFS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDMDISRRAHLKDIAALGAEFGLLPDEMQLFGKTKAKVDLRAQQRLAEQQQGKLIIVT
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEHHHHHHHHHHHHCCCEEEEE
AVTPTPHGEGKTVTTIGLTQSLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQ
EECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEHH
ELNLHLTGDIHAVSSAHNLGAAAIASRLYHETRLGKAEFESQSGQNYLDIAPNGIRWHRV
HCCEEEECCEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCCEEEEEE
VDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLADMRARIGKLVLAVN
ECCCHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEE
RQGAAISAEDLGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDI
CCCCEECHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCCEEHHHH
ALKLADFVVTEGGFGSDMGFEKFCNIKARQSGLAPSAAVLVTTLKALKANSGLTSDADIN
HHHHHHHHEECCCCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
APDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDTDAELNWLIEAVAGTAAFGCEL
CCCHHHHHCCCEEEEEEECCHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCH
SEAFSQGEAGALTLAQTVMRACEQPSEFTLLYPDEMALEAKLSTLAEVGYGATGVSLSEA
HHHHCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHH
AKLQLQELSALGYADLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALV
HHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
GNVMTMPGLGLVPGYLKVDIGADGEITGLG
HHHHHCCCCCCCCCEEEEEECCCCCEECCC
>Mature Secondary Structure
MLTDMDISRRAHLKDIAALGAEFGLLPDEMQLFGKTKAKVDLRAQQRLAEQQQGKLIIVT
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEHHHHHHHHHHHHCCCEEEEE
AVTPTPHGEGKTVTTIGLTQSLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQ
EECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEHH
ELNLHLTGDIHAVSSAHNLGAAAIASRLYHETRLGKAEFESQSGQNYLDIAPNGIRWHRV
HCCEEEECCEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCCEEEEEE
VDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLADMRARIGKLVLAVN
ECCCHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEE
RQGAAISAEDLGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDI
CCCCEECHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCCEEHHHH
ALKLADFVVTEGGFGSDMGFEKFCNIKARQSGLAPSAAVLVTTLKALKANSGLTSDADIN
HHHHHHHHEECCCCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
APDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDTDAELNWLIEAVAGTAAFGCEL
CCCHHHHHCCCEEEEEEECCHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCH
SEAFSQGEAGALTLAQTVMRACEQPSEFTLLYPDEMALEAKLSTLAEVGYGATGVSLSEA
HHHHCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHH
AKLQLQELSALGYADLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALV
HHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
GNVMTMPGLGLVPGYLKVDIGADGEITGLG
HHHHHCCCCCCCCCEEEEEECCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]