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The map label for this gene is frdA [H]

Identifier: 117918860

GI number: 117918860

Start: 461958

End: 463964

Strand: Direct

Name: frdA [H]

Synonym: Shewana3_0403

Alternate gene names: 117918860

Gene position: 461958-463964 (Clockwise)

Preceding gene: 117918859

Following gene: 117918861

Centisome position: 9.29

GC content: 54.36

Gene sequence:

>2007_bases
GTGAAACTGATTTATACCGATTCATTAGTGGTTGGTGCCGGATTGGCTGGCCTGAGGGTGGCCATTGCCTCTAAAGAGCG
CGGGTTAGATACCTTAGTGCTATCGCTTATCCCCGCTAAACGTTCTCACTCTGCGGCGGCGCAGGGCGGAATGCAGGCAA
GCCTTGGTAATGCAGTCAAAGGCATGGGCGATGATGAAGACGTGCACTTTCAAGATACGGTGAAAGGATCGGACTGGGGC
TGCGATCAAGAAGTCGCCAGAATGTTTGCCCATTGTGCGCCTAAGGCGGTGCGTGAATTAGCCAACTGGGGCGTGCCTTG
GACACGTGTAACCGCAGGCCCGAGGGACGTCATTGTTAACGCACAAAAAGTCACCTTGCAGGAAGCCGAAGAAGCCCACG
GTCTGATCAATGCCCGTGACTTTGGTGGCACCAAAAAGTGGCGCACCTGCTACACCGCCGACGGTACCGGCCACTCCTTA
CTCTATGCTATGGATAACAAAGCGATTTCGATGGATATTCCTGTCCACGAACGCGTCGAAGCGCTCTCTATTATCCACGA
CGGTCAACGTTGCCACGGGGTAATTGCCCGCTGTTTAATCACGGGCGAGTTGCGTGCCTATGTCGCGAAATCGACCACTA
TCGCCACCGGTGGCTATGGCCGCATTTATGAAGTCTCAACCAACGCGATTATCTGCGAGGGTATAGGTCAGGCGCTGGCG
CTCGAAACGGGCGTTGCGACCCTTGGCAACATGGAAGCGGTACAGTTCCACCCAACGGCGATTGTGCCCGTGGGGATTTT
AACCACAGAAGGTTGCCGTGGTGATGGTGGCTTGCTGCGGGATAAAGACGGTTACCGTTTTATGCCGGACTATGAACCAG
AGAAGAAAGAGCTGGCGTCGCGGGACGTGGTGTCTCGCCGTATGACTGAACATATGCGTAAAGGTAAGGGCGTCGATAGC
CCCTATGGCCCGCATTTATGGCTCGATATCACCCTACTTGGGCGTAAGCATATCGAAACCAACCTGCGTGAAGTGCAGGA
GATTTGCGAAAACTTCCTCGGGATTGATCCCGCGAAGGACTGGATCCCTGTTCGTCCAACTCAGCACTATTCCATGGGCG
GGATCCGCACTAAGGCAACGGGCGAGAGTCCGCAGCTTAAGGGCTTATTCAGCGTCGGCGAAGCGGCCTGTTGGGATATG
CATGGCTTTAACCGCTTGGGTGGTAACTCGCTCGCCGAAACCGTGGTGGGTGGCATGATTATCGGCAAATATGTGGCTGA
TTTTTGTGAGAATAATAGCCTTGAAATCGACACTCAGCTTGCCGAAAAATTTATGCGACAGGTACAGACTGAAATCGACA
CCTTAGTCGATGGCGAAGGCCATGAAAGCCCCTTCGAACTGAAGCGCGAAATGCAGCGGATTATGATGGATTACGTGGGG
ATTTTCCGTAACGGCCCTGAGCTCGATAAGGCGGTGACTGAGCTAAAGGCGCTGCTTGAACGCTCACGTAAGCTCGGAGT
TAAGTGTAAGAAACGCCACGCTAACCCCGAGCTGGTAGAAGCGCTAAGGGTGAAGCGGATGCTCAAGGTGGCGCTAACTG
TGGCCTGTGGCGCAGCCGCGCGTACCGAAAGCCGTGGTGCCCACGCCCGTGAGGATTATCCGCAGCGTAATGACAGAGAC
TGGCTCAACCGTACTCTCGCCAGTTGGCCCGATGCCGAGGCGTTGGCCCCCGTTTTAAGCTACGAGCCGTTGGATGTGAT
GAAGATGGAGCTGCCGCCGGGATACCGGGGTTATGGTATCGATAATGCCATCGCACACCCCGATACAGCCAAACGCGAGC
AACAAATTGCCGAGATTTTGGCTGGGCTGGGTGATGATGCCGATCGTTATCAACGCCAAGCGGCGCTGATGCCATTCGAG
CTGCCGCCGAGCTTACAAGCTAAAAATGAACGTTTAAGCGATACCTTACAAAGACCATCAGCCAATGTGCTAGGAGAAAA
ATCATAA

Upstream 100 bases:

>100_bases
ATTGCCTCCTTATTGGCATTTTTACCCCACGCGAGTTAGCGAATATAACAAAAGAGTGTTGTCCTAAAACAATAACAGCA
GTACCCGTTAAGGAGCAGGC

Downstream 100 bases:

>100_bases
TGAGCCAAGGTCGCCAGTTAACCTTTAATATTTTTCGTTATGATCCGCAGGAGCCAAATGATAAGCCGAAGATGGTGCGT
TATCAGCTCACCGAAACGCC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQEVARMFAHCAPKAVRELANWGVPWTRVTAGPRDVIVNAQKVTLQEAEEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISMDIPVHERVEALSIIHDGQRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTKATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAEKFMRQVQTEIDTLVDGEGHESPFELKREMQRIMMDYVG
IFRNGPELDKAVTELKALLERSRKLGVKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDAEALAPVLSYEPLDVMKMELPPGYRGYGIDNAIAHPDTAKREQQIAEILAGLGDDADRYQRQAALMPFE
LPPSLQAKNERLSDTLQRPSANVLGEKS

Sequences:

>Translated_668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQEVARMFAHCAPKAVRELANWGVPWTRVTAGPRDVIVNAQKVTLQEAEEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISMDIPVHERVEALSIIHDGQRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTKATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAEKFMRQVQTEIDTLVDGEGHESPFELKREMQRIMMDYVG
IFRNGPELDKAVTELKALLERSRKLGVKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDAEALAPVLSYEPLDVMKMELPPGYRGYGIDNAIAHPDTAKREQQIAEILAGLGDDADRYQRQAALMPFE
LPPSLQAKNERLSDTLQRPSANVLGEKS
>Mature_668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQEVARMFAHCAPKAVRELANWGVPWTRVTAGPRDVIVNAQKVTLQEAEEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISMDIPVHERVEALSIIHDGQRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTKATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAEKFMRQVQTEIDTLVDGEGHESPFELKREMQRIMMDYVG
IFRNGPELDKAVTELKALLERSRKLGVKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDAEALAPVLSYEPLDVMKMELPPGYRGYGIDNAIAHPDTAKREQQIAEILAGLGDDADRYQRQAALMPFE
LPPSLQAKNERLSDTLQRPSANVLGEKS

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=607, Percent_Identity=35.4200988467875, Blast_Score=319, Evalue=4e-87,
Organism=Escherichia coli, GI1786942, Length=607, Percent_Identity=36.2438220757825, Blast_Score=329, Evalue=3e-91,
Organism=Escherichia coli, GI1790597, Length=587, Percent_Identity=36.4565587734242, Blast_Score=320, Evalue=2e-88,
Organism=Escherichia coli, GI1788928, Length=570, Percent_Identity=28.5964912280702, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17505833, Length=550, Percent_Identity=37.6363636363636, Blast_Score=323, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17550100, Length=545, Percent_Identity=38.348623853211, Blast_Score=315, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6322701, Length=597, Percent_Identity=36.8509212730318, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6322416, Length=590, Percent_Identity=36.1016949152542, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI17137288, Length=603, Percent_Identity=36.4842454394693, Blast_Score=325, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24655642, Length=603, Percent_Identity=36.4842454394693, Blast_Score=325, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24655647, Length=603, Percent_Identity=36.4842454394693, Blast_Score=325, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24663005, Length=571, Percent_Identity=34.3257443082312, Blast_Score=278, Evalue=1e-74,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 73395; Mature: 73395

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVK
CEEEEECCHHHHCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHC
GMGDDEDVHFQDTVKGSDWGCDQEVARMFAHCAPKAVRELANWGVPWTRVTAGPRDVIVN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCEEECCCCHHEEEC
AQKVTLQEAEEAHGLINARDFGGTKKWRTCYTADGTGHSLLYAMDNKAISMDIPVHERVE
CHHHHHHHHHHHCCCEECCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEEECCHHHHHH
ALSIIHDGQRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCEEEECCCCCHHH
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCCHHHHHHH
RDVVSRRMTEHMRKGKGVDSPYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTKATGESPQLKGLFSVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCENNSLEIDTQLAEKFMRQVQTEIDTLVDGEGHESPFELKREMQRIMMDYVG
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IFRNGPELDKAVTELKALLERSRKLGVKCKKRHANPELVEALRVKRMLKVALTVACGAAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
RTESRGAHAREDYPQRNDRDWLNRTLASWPDAEALAPVLSYEPLDVMKMELPPGYRGYGI
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCC
DNAIAHPDTAKREQQIAEILAGLGDDADRYQRQAALMPFELPPSLQAKNERLSDTLQRPS
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
ANVLGEKS
CCCCCCCC
>Mature Secondary Structure
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVK
CEEEEECCHHHHCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHC
GMGDDEDVHFQDTVKGSDWGCDQEVARMFAHCAPKAVRELANWGVPWTRVTAGPRDVIVN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCEEECCCCHHEEEC
AQKVTLQEAEEAHGLINARDFGGTKKWRTCYTADGTGHSLLYAMDNKAISMDIPVHERVE
CHHHHHHHHHHHCCCEECCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEEECCHHHHHH
ALSIIHDGQRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCEEEECCCCCHHH
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCCHHHHHHH
RDVVSRRMTEHMRKGKGVDSPYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTKATGESPQLKGLFSVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCENNSLEIDTQLAEKFMRQVQTEIDTLVDGEGHESPFELKREMQRIMMDYVG
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IFRNGPELDKAVTELKALLERSRKLGVKCKKRHANPELVEALRVKRMLKVALTVACGAAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
RTESRGAHAREDYPQRNDRDWLNRTLASWPDAEALAPVLSYEPLDVMKMELPPGYRGYGI
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCC
DNAIAHPDTAKREQQIAEILAGLGDDADRYQRQAALMPFELPPSLQAKNERLSDTLQRPS
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
ANVLGEKS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]