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The map label for this gene is lysA [H]

Identifier: 117918847

GI number: 117918847

Start: 450725

End: 451969

Strand: Direct

Name: lysA [H]

Synonym: Shewana3_0390

Alternate gene names: 117918847

Gene position: 450725-451969 (Clockwise)

Preceding gene: 117918846

Following gene: 117918848

Centisome position: 9.06

GC content: 51.89

Gene sequence:

>1245_bases
TTGGATCACTTTCTCTACCAAGACAATACCCTGTACGCCGAAGGCTGTCGGGTCAATGATTTAGCCCAGCAGTATGGCAC
GCCACTGTATATCTATTCCCGTGCGACGCTCGAACGTCACTGGCATGCGTTTAACAATGCGGTGGCCGACCATCCACATT
TAGTGTGTTACGCGGTGAAAGCCAACTCAAACTTAGCCGTACTGAACGTCTTGGCTCGTTTAGGCAGTGGTTTTGATATT
GTCTCGGGCGGTGAGTTAGCACGGGTGATTGAAGCCGGTGGCGATCCTGCCAAAGTGGTGTTTTCGGGCGTGGGTAAAAC
CGTTGCCGAAATGGAACAGGCACTTAACCTCGGTATTTATTGCTTTAACGTCGAATCGAGCGCCGAGCTTGAACAACTTA
ATGACGTTGCAGGCCGCTTAGGTAAAGTTGCCCCAGTGTCACTGCGGGTGAATCCCGATGTCGATGCCGGTACGCATCCT
TATATCTCGACGGGCCTTAAAGAGAACAAATTTGGTATCGCCATGGATGAGGCCGAAGTCGTATTCGCCCGTGCCCATGC
GCTGCCACATTTACAGGTAAAAGGGGTAGATTGCCATATTGGTTCACAGCTGACCGAGATCCAGCCTTTCCTCGATGCGA
TGGACAGAATGTTAGCCCTTATCGACCGTCTGGCCGATCAAGGCATTGTGATTGAACACTTCGATGTGGGTGGCGGTTTA
GGGGTGACCTATGATGATGAAACCCCGCCGCATCCCGATGTTTACGCTGCTGCACTGCTCGCGCGTTTAGGTGATCGCAA
GCTCAAGTTAATTTTCGAGCCGGGTCGTGCCATCGCCGCTAACGCGGGGATTTTCGTCACTCAGGTGCTGTACCTTAAAG
AAAACAGCGATAAACGTTTTGCGATTGTCGACGGCGCGATGAACGACTTAATTCGTCCTGCACTCTATAGCGCTTGGCAA
AATATCATTCCGGTAAATCCAAGGGATGAACAAGCGCAAGTATTTGATATCGTAGGGCCAGTGTGCGAAACCGGTGACTT
TTTAGGTAAAGACAGAGCACTCGCGATTGCGGCGGGGGATTTACTGGTTGTGCGCTCGAGCGGTGCCTACGGTTTTGCCA
TGGCTTCTAACTATAACACTCGTCCGCGTGCGGCCGAGGTGATGGTCGATGGTGACAAGGCTTATCTGGTGCGTGAGCGA
GAAAAATTAGCGCAGCTCTGGCAAGGTGAGCAACTCCTGCCGTAA

Upstream 100 bases:

>100_bases
TGAGGCAACCCCTGCCGACACGGCGGCGCCTCAAGCTGAAACTGAAAAAACACAATAATAATCAGCATAATTACAACAAA
GCGCAGTAAGGAATCGGACA

Downstream 100 bases:

>100_bases
ACTAGAAAATTATATTGATTCAGGCGCTTGGCTAGTTGATGGCGGCGCCTAGGCTTAAAGGATAAGTATCTTGATCCAAT
TCACTAAGATGCACGGACTG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDHFLYQDNTLYAEGCRVNDLAQQYGTPLYIYSRATLERHWHAFNNAVADHPHLVCYAVKANSNLAVLNVLARLGSGFDI
VSGGELARVIEAGGDPAKVVFSGVGKTVAEMEQALNLGIYCFNVESSAELEQLNDVAGRLGKVAPVSLRVNPDVDAGTHP
YISTGLKENKFGIAMDEAEVVFARAHALPHLQVKGVDCHIGSQLTEIQPFLDAMDRMLALIDRLADQGIVIEHFDVGGGL
GVTYDDETPPHPDVYAAALLARLGDRKLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFAIVDGAMNDLIRPALYSAWQ
NIIPVNPRDEQAQVFDIVGPVCETGDFLGKDRALAIAAGDLLVVRSSGAYGFAMASNYNTRPRAAEVMVDGDKAYLVRER
EKLAQLWQGEQLLP

Sequences:

>Translated_414_residues
MDHFLYQDNTLYAEGCRVNDLAQQYGTPLYIYSRATLERHWHAFNNAVADHPHLVCYAVKANSNLAVLNVLARLGSGFDI
VSGGELARVIEAGGDPAKVVFSGVGKTVAEMEQALNLGIYCFNVESSAELEQLNDVAGRLGKVAPVSLRVNPDVDAGTHP
YISTGLKENKFGIAMDEAEVVFARAHALPHLQVKGVDCHIGSQLTEIQPFLDAMDRMLALIDRLADQGIVIEHFDVGGGL
GVTYDDETPPHPDVYAAALLARLGDRKLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFAIVDGAMNDLIRPALYSAWQ
NIIPVNPRDEQAQVFDIVGPVCETGDFLGKDRALAIAAGDLLVVRSSGAYGFAMASNYNTRPRAAEVMVDGDKAYLVRER
EKLAQLWQGEQLLP
>Mature_414_residues
MDHFLYQDNTLYAEGCRVNDLAQQYGTPLYIYSRATLERHWHAFNNAVADHPHLVCYAVKANSNLAVLNVLARLGSGFDI
VSGGELARVIEAGGDPAKVVFSGVGKTVAEMEQALNLGIYCFNVESSAELEQLNDVAGRLGKVAPVSLRVNPDVDAGTHP
YISTGLKENKFGIAMDEAEVVFARAHALPHLQVKGVDCHIGSQLTEIQPFLDAMDRMLALIDRLADQGIVIEHFDVGGGL
GVTYDDETPPHPDVYAAALLARLGDRKLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFAIVDGAMNDLIRPALYSAWQ
NIIPVNPRDEQAQVFDIVGPVCETGDFLGKDRALAIAAGDLLVVRSSGAYGFAMASNYNTRPRAAEVMVDGDKAYLVRER
EKLAQLWQGEQLLP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=363, Percent_Identity=26.1707988980716, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI22538418, Length=355, Percent_Identity=25.9154929577465, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI21361583, Length=355, Percent_Identity=25.9154929577465, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1789203, Length=435, Percent_Identity=32.183908045977, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17562780, Length=352, Percent_Identity=23.5795454545455, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322664, Length=379, Percent_Identity=24.0105540897098, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586472, Length=342, Percent_Identity=25.1461988304094, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586474, Length=370, Percent_Identity=24.8648648648649, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45076; Mature: 45076

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFLYQDNTLYAEGCRVNDLAQQYGTPLYIYSRATLERHWHAFNNAVADHPHLVCYAVK
CCCEEECCCEEEECCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCCCCCCEEEEEEE
ANSNLAVLNVLARLGSGFDIVSGGELARVIEAGGDPAKVVFSGVGKTVAEMEQALNLGIY
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCEE
CFNVESSAELEQLNDVAGRLGKVAPVSLRVNPDVDAGTHPYISTGLKENKFGIAMDEAEV
EEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCEEEECCHHE
VFARAHALPHLQVKGVDCHIGSQLTEIQPFLDAMDRMLALIDRLADQGIVIEHFDVGGGL
EEEHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
GVTYDDETPPHPDVYAAALLARLGDRKLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRF
EEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEECCCEEEEEEEEEEECCCCEE
AIVDGAMNDLIRPALYSAWQNIIPVNPRDEQAQVFDIVGPVCETGDFLGKDRALAIAAGD
EEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHCCCCCCCCCCEEEEEECC
LLVVRSSGAYGFAMASNYNTRPRAAEVMVDGDKAYLVREREKLAQLWQGEQLLP
EEEEECCCCEEEEEECCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDHFLYQDNTLYAEGCRVNDLAQQYGTPLYIYSRATLERHWHAFNNAVADHPHLVCYAVK
CCCEEECCCEEEECCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCCCCCCEEEEEEE
ANSNLAVLNVLARLGSGFDIVSGGELARVIEAGGDPAKVVFSGVGKTVAEMEQALNLGIY
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCEE
CFNVESSAELEQLNDVAGRLGKVAPVSLRVNPDVDAGTHPYISTGLKENKFGIAMDEAEV
EEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCEEEECCHHE
VFARAHALPHLQVKGVDCHIGSQLTEIQPFLDAMDRMLALIDRLADQGIVIEHFDVGGGL
EEEHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
GVTYDDETPPHPDVYAAALLARLGDRKLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRF
EEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEECCCEEEEEEEEEEECCCCEE
AIVDGAMNDLIRPALYSAWQNIIPVNPRDEQAQVFDIVGPVCETGDFLGKDRALAIAAGD
EEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHCCCCCCCCCCEEEEEECC
LLVVRSSGAYGFAMASNYNTRPRAAEVMVDGDKAYLVREREKLAQLWQGEQLLP
EEEEECCCCEEEEEECCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]