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The map label for this gene is moaE [H]

Identifier: 116872439

GI number: 116872439

Start: 1039088

End: 1039510

Strand: Direct

Name: moaE [H]

Synonym: lwe1021

Alternate gene names: 116872439

Gene position: 1039088-1039510 (Clockwise)

Preceding gene: 116872438

Following gene: 116872440

Centisome position: 36.92

GC content: 38.3

Gene sequence:

>423_bases
ATGAAATATGTAGCATTGCAACATGAAAAAATAGAAATCGGCTCACTTTCTGAAAAACTAATCAATAAAAATCATGGTGG
GGTGAACCTGTTTATTGGAACGATTCGAGAATGGACTGGCGAAATTCAAACAGAAGAAATTCGTTACACTTCCTACGAAA
AAATGGCGCTCAAAGAACTAAACAAGTTGGCTACAGAAGTTGAAGAGAAGTGGGGAGCAGATGTTGTTATCGTTCACCGG
CTGGGAGTTTTGCAAATAACAGATATCGCTGTATTTATTGGGGTATCAACTCCACACCGTGCAGCTTGCTATGAAGGTTC
CAGATATATTATTGAACGTTTAAAAGAACGTGTGCCTATATGGAAAGAAGAAAAAGATGTAGATAAGACAAGGTGGGGTG
GCATAAATGCTAACAACAGTTAA

Upstream 100 bases:

>100_bases
TCGCGACATATAATCCCGCGCTAAAAGAAGAAGCGATTTTTATTGGAGATGAGCAAACTTTAATTACATTTGCGGAAACG
TTAATCAAGGAGTTTTTACA

Downstream 100 bases:

>100_bases
ATTTTTTGCTTTTTTGGCCGAGAAGACACATAAAACAGAAGTGAAATTGAATTTGCAACAATGTCAAACAGTTGGTGAGG
TTAGGGAAGTCATTAGTAGT

Product: molybdenum cofactor biosynthesis protein E

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MKYVALQHEKIEIGSLSEKLINKNHGGVNLFIGTIREWTGEIQTEEIRYTSYEKMALKELNKLATEVEEKWGADVVIVHR
LGVLQITDIAVFIGVSTPHRAACYEGSRYIIERLKERVPIWKEEKDVDKTRWGGINANNS

Sequences:

>Translated_140_residues
MKYVALQHEKIEIGSLSEKLINKNHGGVNLFIGTIREWTGEIQTEEIRYTSYEKMALKELNKLATEVEEKWGADVVIVHR
LGVLQITDIAVFIGVSTPHRAACYEGSRYIIERLKERVPIWKEEKDVDKTRWGGINANNS
>Mature_140_residues
MKYVALQHEKIEIGSLSEKLINKNHGGVNLFIGTIREWTGEIQTEEIRYTSYEKMALKELNKLATEVEEKWGADVVIVHR
LGVLQITDIAVFIGVSTPHRAACYEGSRYIIERLKERVPIWKEEKDVDKTRWGGINANNS

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=127, Percent_Identity=33.0708661417323, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1787003, Length=108, Percent_Identity=31.4814814814815, Blast_Score=66, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17509279, Length=125, Percent_Identity=27.2, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356259, Length=126, Percent_Identity=35.7142857142857, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 16055; Mature: 16055

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYVALQHEKIEIGSLSEKLINKNHGGVNLFIGTIREWTGEIQTEEIRYTSYEKMALKEL
CCCEECCCCEEECCHHHHHHHCCCCCCEEEEEEHHHHHCCCCCCCCEEHHHHHHHHHHHH
NKLATEVEEKWGADVVIVHRLGVLQITDIAVFIGVSTPHRAACYEGSRYIIERLKERVPI
HHHHHHHHHHHCCCEEEEECCCEEEEEEEEEEEECCCCCCHHHHCCCHHHHHHHHHHCCC
WKEEKDVDKTRWGGINANNS
CCCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MKYVALQHEKIEIGSLSEKLINKNHGGVNLFIGTIREWTGEIQTEEIRYTSYEKMALKEL
CCCEECCCCEEECCHHHHHHHCCCCCCEEEEEEHHHHHCCCCCCCCEEHHHHHHHHHHHH
NKLATEVEEKWGADVVIVHRLGVLQITDIAVFIGVSTPHRAACYEGSRYIIERLKERVPI
HHHHHHHHHHHCCCEEEEECCCEEEEEEEEEEEECCCCCCHHHHCCCHHHHHHHHHHCCC
WKEEKDVDKTRWGGINANNS
CCCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]