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The map label for this gene is gor [H]

Identifier: 116872309

GI number: 116872309

Start: 920201

End: 921550

Strand: Direct

Name: gor [H]

Synonym: lwe0891

Alternate gene names: 116872309

Gene position: 920201-921550 (Clockwise)

Preceding gene: 116872308

Following gene: 116872310

Centisome position: 32.7

GC content: 39.11

Gene sequence:

>1350_bases
ATGGAGAAGCATTATGATTATATTGCGATTGGCGGCGGTAGTGGCGGAATTGCTTCTATTAATCGCGCGGCAATGCACGG
AGCAAAGTGTGCACTAATCGAACCCAAATTTTTAGGAGGCACATGTGTGAACGTTGGCTGTGTTCCTAAAAAAGTAATGT
GGTACGGTGCACAAATTAAAGAAGCGATGGATTTATACGCAGATGCTTATGGTTATCAAGTAGATGCATCCTTTAACTTC
CAAAAATTAGTTGAAAATCGGGAAGCATACATCGAACGCATTCGCGGTTCTTATAAAAACGGACTTGATAATAATAAAGT
CGAATGGATAAAAGGGTATGCCGAATTTGTTGATGAAAAAACGTTGCGTGTAAACGGCGAAATAGTGACAGCTGATCATA
TTTTAATTGCGACGGGCGGAGAACCAGTGCTTCCTTCTATTCCAGGTGCAGAATATGGAATAACTTCAGATGGTTTTTTT
GCATTAAAAGAACTTCCTAAAAAAGTAGCAGTTATTGGTGCCGGTTATATTGCTGTTGAACTTGCTGGCGTTTTACAACA
ATTAGGTTCAGAAACACATTTATTTGTACGGAAACATGCGCCGCTCAGAAATTTTGACCCACTTTTAACAGATACATTAA
CCGAAATTATCGAGCAATCGGATATGATGTTGCACAAACACGCAGTACCACAAAAAGTGGAAAAAAATTCGGATGGCAGT
TTAACATTGAGCTTAGAAGATGGTCGCACAGAAACCGTCGATACGATTATTTGGGCAATTGGCCGTAAACCGGTTATCAC
AGGACTTCAAATTGAAAAAGCTGGCGTAGAATTATTAGAAAGTGGACATATTGCTGTAGATAAATTTCAAAACACGAATG
TGGAAGGGATTTATGCAGTTGGCGACGTCACGGGTCACTATGAATTAACACCAGTCGCTATCGCTGCTGGACGCCGTCTT
TCAGAACGACTTTTTAACAATAAAAAAGATGCTCATTTAAGTTATGAAAACATTCCAACCGTTGTATTTAGTCATCCTGC
CATTGGTACTGTTGGTTTAACTGAGCCAGAAGCAATTGAAAAATATGGTAAAGAAAATATTAAAATATACACTTCTAGTT
TTACTTCAATGTATACAGCTATTACAGATCACCGTGAACCTTGTCGAATGAAATTAATCTGCGAAGGAAATACAGAACGT
GTCATCGGCTTGCACGGCATTGGTTATGGTGTGGATGAAATGATTCAAGGATTTGCTGTAGCTATTAATATGGGCGCAAC
GAAATCCGATTTTGATAACACGGTCGCCATTCACCCAACAGGATCAGAAGAATTTGTTACAATGAAATAG

Upstream 100 bases:

>100_bases
TGCAAGTGATTAAACGTTACTTACCGAATCCGCGAGTTCTTGCCATTATGCGGGGCGAAGCGTATTTATAAAAATGAAGA
AATGTTAGGAGAGATTTTGA

Downstream 100 bases:

>100_bases
ATAACAACAAACGAGGAGGAAGAACGTAATGGGAAAAAAATTATCACTTTATTTTGTAAGACATGGTCAAACGTATTTAA
ATAAAAATATACGCATGCAA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIKEAMDLYADAYGYQVDASFNF
QKLVENREAYIERIRGSYKNGLDNNKVEWIKGYAEFVDEKTLRVNGEIVTADHILIATGGEPVLPSIPGAEYGITSDGFF
ALKELPKKVAVIGAGYIAVELAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMMLHKHAVPQKVEKNSDGS
LTLSLEDGRTETVDTIIWAIGRKPVITGLQIEKAGVELLESGHIAVDKFQNTNVEGIYAVGDVTGHYELTPVAIAAGRRL
SERLFNNKKDAHLSYENIPTVVFSHPAIGTVGLTEPEAIEKYGKENIKIYTSSFTSMYTAITDHREPCRMKLICEGNTER
VIGLHGIGYGVDEMIQGFAVAINMGATKSDFDNTVAIHPTGSEEFVTMK

Sequences:

>Translated_449_residues
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIKEAMDLYADAYGYQVDASFNF
QKLVENREAYIERIRGSYKNGLDNNKVEWIKGYAEFVDEKTLRVNGEIVTADHILIATGGEPVLPSIPGAEYGITSDGFF
ALKELPKKVAVIGAGYIAVELAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMMLHKHAVPQKVEKNSDGS
LTLSLEDGRTETVDTIIWAIGRKPVITGLQIEKAGVELLESGHIAVDKFQNTNVEGIYAVGDVTGHYELTPVAIAAGRRL
SERLFNNKKDAHLSYENIPTVVFSHPAIGTVGLTEPEAIEKYGKENIKIYTSSFTSMYTAITDHREPCRMKLICEGNTER
VIGLHGIGYGVDEMIQGFAVAINMGATKSDFDNTVAIHPTGSEEFVTMK
>Mature_449_residues
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIKEAMDLYADAYGYQVDASFNF
QKLVENREAYIERIRGSYKNGLDNNKVEWIKGYAEFVDEKTLRVNGEIVTADHILIATGGEPVLPSIPGAEYGITSDGFF
ALKELPKKVAVIGAGYIAVELAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMMLHKHAVPQKVEKNSDGS
LTLSLEDGRTETVDTIIWAIGRKPVITGLQIEKAGVELLESGHIAVDKFQNTNVEGIYAVGDVTGHYELTPVAIAAGRRL
SERLFNNKKDAHLSYENIPTVVFSHPAIGTVGLTEPEAIEKYGKENIKIYTSSFTSMYTAITDHREPCRMKLICEGNTER
VIGLHGIGYGVDEMIQGFAVAINMGATKSDFDNTVAIHPTGSEEFVTMK

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=53.2608695652174, Blast_Score=457, Evalue=1e-129,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=38.9473684210526, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI33519430, Length=431, Percent_Identity=35.9628770301624, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI33519428, Length=431, Percent_Identity=35.9628770301624, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI33519426, Length=431, Percent_Identity=35.9628770301624, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI148277071, Length=431, Percent_Identity=35.9628770301624, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI148277065, Length=431, Percent_Identity=35.9628770301624, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI291045266, Length=431, Percent_Identity=36.6589327146172, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI291045268, Length=430, Percent_Identity=34.1860465116279, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=30.1724137931034, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=68.6666666666667, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=447, Percent_Identity=29.3064876957494, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=27.9735682819383, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87082354, Length=459, Percent_Identity=27.2331154684096, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1787114, Length=213, Percent_Identity=29.5774647887324, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=53.7777777777778, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=53.7777777777778, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=36.4605543710021, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71982272, Length=487, Percent_Identity=34.2915811088296, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=30.5676855895196, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=50.4310344827586, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321091, Length=480, Percent_Identity=31.0416666666667, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=24.1090146750524, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=39.1489361702128, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=39.1489361702128, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=39.1489361702128, Blast_Score=287, Evalue=8e-78,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=36.0169491525424, Blast_Score=261, Evalue=9e-70,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=28.3549783549784, Blast_Score=152, Evalue=4e-37,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49092; Mature: 49092

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIK
CCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
EAMDLYADAYGYQVDASFNFQKLVENREAYIERIRGSYKNGLDNNKVEWIKGYAEFVDEK
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
TLRVNGEIVTADHILIATGGEPVLPSIPGAEYGITSDGFFALKELPKKVAVIGAGYIAVE
EEEECCEEEEECEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCHHEEEEECCHHHHH
LAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMMLHKHAVPQKVEKNSDGS
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCE
LTLSLEDGRTETVDTIIWAIGRKPVITGLQIEKAGVELLESGHIAVDKFQNTNVEGIYAV
EEEEECCCCCHHHHHHHHHCCCCCEEECEEEEHHHHHHHHCCCEEEEECCCCCCCEEEEE
GDVTGHYELTPVAIAAGRRLSERLFNNKKDAHLSYENIPTVVFSHPAIGTVGLTEPEAIE
ECCCCCEEECEEHHHHCHHHHHHHHCCCCCCEEECCCCCEEEEECCCCCCCCCCCHHHHH
KYGKENIKIYTSSFTSMYTAITDHREPCRMKLICEGNTERVIGLHGIGYGVDEMIQGFAV
HCCCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHCCEEE
AINMGATKSDFDNTVAIHPTGSEEFVTMK
EEECCCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIK
CCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
EAMDLYADAYGYQVDASFNFQKLVENREAYIERIRGSYKNGLDNNKVEWIKGYAEFVDEK
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
TLRVNGEIVTADHILIATGGEPVLPSIPGAEYGITSDGFFALKELPKKVAVIGAGYIAVE
EEEECCEEEEECEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCHHEEEEECCHHHHH
LAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMMLHKHAVPQKVEKNSDGS
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCE
LTLSLEDGRTETVDTIIWAIGRKPVITGLQIEKAGVELLESGHIAVDKFQNTNVEGIYAV
EEEEECCCCCHHHHHHHHHCCCCCEEECEEEEHHHHHHHHCCCEEEEECCCCCCCEEEEE
GDVTGHYELTPVAIAAGRRLSERLFNNKKDAHLSYENIPTVVFSHPAIGTVGLTEPEAIE
ECCCCCEEECEEHHHHCHHHHHHHHCCCCCCEEECCCCCEEEEECCCCCCCCCCCHHHHH
KYGKENIKIYTSSFTSMYTAITDHREPCRMKLICEGNTERVIGLHGIGYGVDEMIQGFAV
HCCCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHCCEEE
AINMGATKSDFDNTVAIHPTGSEEFVTMK
EEECCCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]