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The map label for this gene is ndoA [H]

Identifier: 116872290

GI number: 116872290

Start: 903884

End: 904228

Strand: Direct

Name: ndoA [H]

Synonym: lwe0870

Alternate gene names: 116872290

Gene position: 903884-904228 (Clockwise)

Preceding gene: 116872289

Following gene: 116872291

Centisome position: 32.12

GC content: 43.48

Gene sequence:

>345_bases
ATGGTGAAGCGTGGTGACGTATACTACGCGGACCTTTCCCCCGTGGTCGGGAGCGAGCAAGGGGGAATAAGGCCTGTTCT
CATCATACAGAACGATATTGGTAATAGATTCAGTCCAACTGTGATTGTGGCAGCAATAACCGCAAAAATTCAAAAAGCGA
AGTTGCCAACACACGTGGAAGCTACTCGTAAAGATGGCTTTGAGAGAGATTCTGTCATTCTTTTAGAACAAATTAGAACG
ATTGACAAACAACGCCTGACAGATAAAATTACACATTTGGACGAGGAACTAATGGCCAAGGTAAATAAGGCGCTTGAAGT
CAGCCTAGGAGTAGTAGAATTTTAA

Upstream 100 bases:

>100_bases
AGAAATGGCAACAATTAATTTTGCTATTGCATGCGAGTGTACCCATGTCGAAGCAGAAGCAGAAGATAGGAATATTAGTA
TTTTAGGAGGTTAATGGCTG

Downstream 100 bases:

>100_bases
TCCATCCTAAAAAATAACATAAAATGATGAATGCAGGACAAAAGGGTCTGACGTAAAAAGATACTTAATACATAATGAAA
AAATTAACTACAATGGCTAA

Product: PemK family transcriptional regulator

Products: NA

Alternate protein names: Endoribonuclease EndoA; Toxin EndoA [H]

Number of amino acids: Translated: 114; Mature: 114

Protein sequence:

>114_residues
MVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIRT
IDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF

Sequences:

>Translated_114_residues
MVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIRT
IDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF
>Mature_114_residues
MVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIRT
IDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF

Specific function: Part of a toxin-antitoxin (TA) module. Has specificity for UAC sequences, yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single

COG id: COG2337

COG function: function code T; Growth inhibitor

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PemK/MazF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003477
- InterPro:   IPR011067 [H]

Pfam domain/function: PF02452 PemK [H]

EC number: NA

Molecular weight: Translated: 12671; Mature: 12671

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVE
CCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
ATRKDGFERDSVILLEQIRTIDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEECC
>Mature Secondary Structure
MVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVE
CCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
ATRKDGFERDSVILLEQIRTIDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]