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The map label for this gene is uvrC [H]

Identifier: 116872259

GI number: 116872259

Start: 871666

End: 872766

Strand: Direct

Name: uvrC [H]

Synonym: lwe0839

Alternate gene names: 116872259

Gene position: 871666-872766 (Clockwise)

Preceding gene: 116872258

Following gene: 116872260

Centisome position: 30.97

GC content: 34.24

Gene sequence:

>1101_bases
TTGGATACCAAGTTGCAAACGAAATTAACCTTATTACCTGAATCACCAGGTTGTTATATATATAAAGATGAAAATAATGA
AATTCTCTATATTGGCAAATCAAAATGCTTGAAGAATCGTGTAAAATCTTATTTTCATAGTAAACAAATTGGTAAAACAG
CAAGACTTGTTCGGCAAATTCGTGATTTAGAATTGATTATCACTACTTCCGAAAAAGAAGCCTTACTTCTCGAAATGATT
TTAATTCAGAAATACCAGCCACCTTTTAATATCCAGTTAAAAGAAGGAACGAGCTATCCTTATATTAAAATCACGAATGA
AAAAAATCCGCATATCGAAGTTGTTTTTGAAGCAAAACAAGATGGCGCACATTATTTTGGTCCTTATCCTGGCCGTTATT
CTGCCAGACAAACAGTTGACCTCATCCAAAAATTATTTCCACTATGTCGTTGTGACGGAAAACCAGGCCGGCCATGTTTA
TATTACCATCTTGGACTTTGCTTAGGTCCTTGCCTAAGAGAGATTGATCCAGCTGTTTATAAAGCACAAATTCACAAAAT
TTCTCGTTTCTTAGAGGGAGATGTCAAACCAGTGAAGAAGAAAATTCAAGCAATCATGCAAGAAGCAACAGACAAACTTG
AATTCGAACGTGCTGCAGAACAACGAGATAAACTTCATGCGATAAATGAAACAATTGAAAAACAACATATTATTTTCCCC
GGTTTAAAAAATCGTGATATTATTGGTTGTTATGAACAAGACAATTACCTCAGTGTTTTTGTTTTCTTTGTCCGAAATGG
AGCAATTAATGGTAGGAAATGGCATGTTTTTCAAGTGGAGAAATCGCTTCAAGAAGATTTAGCGCATTTTATTAACCAGT
TTTATGAAGATCCTAATAATATCCAGCCAAAAGAGTTATTAATTGCGGAAAAACTAGATAAATTATCTTTAGCAGAACCG
CTTCGTAAGGCATGTGTATTCCCACAAAAAGGCGGGAAAAAGAAACAAATCAACTTAGCAAACGAGAATGCTAAAAGCAC
GTATATCGCTTATGCCAAGATGAAAGAATACGATTTTGAAAACCAATTAAAAAACAGTTAG

Upstream 100 bases:

>100_bases
TAAGAAGAACTAGCCAGAGTTTTTGCGCTAGTTCTTCTTTCTTCTTTACAAAAAGGATAAGGAGGGATAGAATAGATGTT
CTAGAAGGAGGGGAACCCCT

Downstream 100 bases:

>100_bases
AAGCTAGCTTTCATTGATTAGCTTCTTATCTTTGTTATATTGAAAATCTTATCATAAATAAGTATGGTCAATAATCTACC
CTTATGGTAAAATCTTACGA

Product: excinuclease ABC, subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MDTKLQTKLTLLPESPGCYIYKDENNEILYIGKSKCLKNRVKSYFHSKQIGKTARLVRQIRDLELIITTSEKEALLLEMI
LIQKYQPPFNIQLKEGTSYPYIKITNEKNPHIEVVFEAKQDGAHYFGPYPGRYSARQTVDLIQKLFPLCRCDGKPGRPCL
YYHLGLCLGPCLREIDPAVYKAQIHKISRFLEGDVKPVKKKIQAIMQEATDKLEFERAAEQRDKLHAINETIEKQHIIFP
GLKNRDIIGCYEQDNYLSVFVFFVRNGAINGRKWHVFQVEKSLQEDLAHFINQFYEDPNNIQPKELLIAEKLDKLSLAEP
LRKACVFPQKGGKKKQINLANENAKSTYIAYAKMKEYDFENQLKNS

Sequences:

>Translated_366_residues
MDTKLQTKLTLLPESPGCYIYKDENNEILYIGKSKCLKNRVKSYFHSKQIGKTARLVRQIRDLELIITTSEKEALLLEMI
LIQKYQPPFNIQLKEGTSYPYIKITNEKNPHIEVVFEAKQDGAHYFGPYPGRYSARQTVDLIQKLFPLCRCDGKPGRPCL
YYHLGLCLGPCLREIDPAVYKAQIHKISRFLEGDVKPVKKKIQAIMQEATDKLEFERAAEQRDKLHAINETIEKQHIIFP
GLKNRDIIGCYEQDNYLSVFVFFVRNGAINGRKWHVFQVEKSLQEDLAHFINQFYEDPNNIQPKELLIAEKLDKLSLAEP
LRKACVFPQKGGKKKQINLANENAKSTYIAYAKMKEYDFENQLKNS
>Mature_366_residues
MDTKLQTKLTLLPESPGCYIYKDENNEILYIGKSKCLKNRVKSYFHSKQIGKTARLVRQIRDLELIITTSEKEALLLEMI
LIQKYQPPFNIQLKEGTSYPYIKITNEKNPHIEVVFEAKQDGAHYFGPYPGRYSARQTVDLIQKLFPLCRCDGKPGRPCL
YYHLGLCLGPCLREIDPAVYKAQIHKISRFLEGDVKPVKKKIQAIMQEATDKLEFERAAEQRDKLHAINETIEKQHIIFP
GLKNRDIIGCYEQDNYLSVFVFFVRNGAINGRKWHVFQVEKSLQEDLAHFINQFYEDPNNIQPKELLIAEKLDKLSLAEP
LRKACVFPQKGGKKKQINLANENAKSTYIAYAKMKEYDFENQLKNS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=359, Percent_Identity=33.983286908078, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI1788037, Length=181, Percent_Identity=33.7016574585635, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 42467; Mature: 42467

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTKLQTKLTLLPESPGCYIYKDENNEILYIGKSKCLKNRVKSYFHSKQIGKTARLVRQI
CCCCCCEEEEEEECCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLELIITTSEKEALLLEMILIQKYQPPFNIQLKEGTSYPYIKITNEKNPHIEVVFEAKQ
HCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCEEEEEEECC
DGAHYFGPYPGRYSARQTVDLIQKLFPLCRCDGKPGRPCLYYHLGLCLGPCLREIDPAVY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHH
KAQIHKISRFLEGDVKPVKKKIQAIMQEATDKLEFERAAEQRDKLHAINETIEKQHIIFP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECC
GLKNRDIIGCYEQDNYLSVFVFFVRNGAINGRKWHVFQVEKSLQEDLAHFINQFYEDPNN
CCCCCCEEEEECCCCCEEEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
IQPKELLIAEKLDKLSLAEPLRKACVFPQKGGKKKQINLANENAKSTYIAYAKMKEYDFE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEEEEHHHHCCCH
NQLKNS
HHHCCC
>Mature Secondary Structure
MDTKLQTKLTLLPESPGCYIYKDENNEILYIGKSKCLKNRVKSYFHSKQIGKTARLVRQI
CCCCCCEEEEEEECCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLELIITTSEKEALLLEMILIQKYQPPFNIQLKEGTSYPYIKITNEKNPHIEVVFEAKQ
HCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCEEEEEEECC
DGAHYFGPYPGRYSARQTVDLIQKLFPLCRCDGKPGRPCLYYHLGLCLGPCLREIDPAVY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHH
KAQIHKISRFLEGDVKPVKKKIQAIMQEATDKLEFERAAEQRDKLHAINETIEKQHIIFP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECC
GLKNRDIIGCYEQDNYLSVFVFFVRNGAINGRKWHVFQVEKSLQEDLAHFINQFYEDPNN
CCCCCCEEEEECCCCCEEEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
IQPKELLIAEKLDKLSLAEPLRKACVFPQKGGKKKQINLANENAKSTYIAYAKMKEYDFE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEEEEHHHHCCCH
NQLKNS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]