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The map label for this gene is ahpC [H]

Identifier: 116689961

GI number: 116689961

Start: 2156610

End: 2157158

Strand: Direct

Name: ahpC [H]

Synonym: Bcen2424_1940

Alternate gene names: 116689961

Gene position: 2156610-2157158 (Clockwise)

Preceding gene: 116689960

Following gene: 116689962

Centisome position: 61.9

GC content: 59.56

Gene sequence:

>549_bases
ATGAAAACCGTGGGCGATAAACTCGAAGCTTTCACCGTCGTAGCCGCGAAGCCGGGCTTCAATAATCACGAGGAAAACGG
CCAGTCGGCGTTCGAGACCGTCACCGAAGCGTCGTTCCCGGGCAAGTGGAAGATCATCTACTTCTATCCGAAGGATTTCA
CGTTCGTGTGCCCGACGGAAATCGTCGAATTCGCGAAGCTCACGAAGCAGTTCGAAGAGCGCGACGCCGTCCTGCTCGGC
GGCAGCTCGGACAACGAATTCGTCAAGCTCGCATGGCGCCGTGAACACAAGGATCTCGACAAGCTGAACCACTACTCGTT
CGGCGACGTCAAGGGCGAACTGATCGACCAGCTCGGCGTGCGCGACAAGGAAGCCGGCGTGGCCCTGCGTGCAACGTTCA
TCGTCGATCCGGACAACACGATCCAGCACGTTTCGGTGAACAACCTGAACGTCGGCCGTAGCCCGGAAGAAGTCCTGCGC
ATTCTGGACGGCCTGCAAACGGACGAACTCTGCCCGTGCAACCGCGCAGTCGGCGGCGCCACGCTGTAA

Upstream 100 bases:

>100_bases
TGCCAATAGTGTTATAGTTTTACCCATGCTGTCACATCATCGTTGCAGCACCGAGGTAGCTTGACTCAGTCTTCTTCCCA
ACTCACACAGGAGTATCCGC

Downstream 100 bases:

>100_bases
GCGTAGCAATGCACGAAGCCCGCGGCGCACGTCCTGCCTGCGGGCTTTTTTAACGGCCAACCCATAGGAGATATCAATGA
AATTCATCGACTCGATTAAG

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: MtAhpC; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKTVGDKLEAFTVVAAKPGFNNHEENGQSAFETVTEASFPGKWKIIYFYPKDFTFVCPTEIVEFAKLTKQFEERDAVLLG
GSSDNEFVKLAWRREHKDLDKLNHYSFGDVKGELIDQLGVRDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRSPEEVLR
ILDGLQTDELCPCNRAVGGATL

Sequences:

>Translated_182_residues
MKTVGDKLEAFTVVAAKPGFNNHEENGQSAFETVTEASFPGKWKIIYFYPKDFTFVCPTEIVEFAKLTKQFEERDAVLLG
GSSDNEFVKLAWRREHKDLDKLNHYSFGDVKGELIDQLGVRDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRSPEEVLR
ILDGLQTDELCPCNRAVGGATL
>Mature_182_residues
MKTVGDKLEAFTVVAAKPGFNNHEENGQSAFETVTEASFPGKWKIIYFYPKDFTFVCPTEIVEFAKLTKQFEERDAVLLG
GSSDNEFVKLAWRREHKDLDKLNHYSFGDVKGELIDQLGVRDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRSPEEVLR
ILDGLQTDELCPCNRAVGGATL

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=156, Percent_Identity=39.1025641025641, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI32483377, Length=156, Percent_Identity=39.1025641025641, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI32189392, Length=160, Percent_Identity=38.125, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI4505591, Length=172, Percent_Identity=32.5581395348837, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI32455266, Length=172, Percent_Identity=32.5581395348837, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI32455264, Length=172, Percent_Identity=32.5581395348837, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=32.7044025157233, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI33188454, Length=66, Percent_Identity=42.4242424242424, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786822, Length=171, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17554494, Length=151, Percent_Identity=36.4238410596026, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193204376, Length=159, Percent_Identity=35.2201257861635, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI32565831, Length=159, Percent_Identity=35.2201257861635, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323613, Length=159, Percent_Identity=40.251572327044, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320661, Length=159, Percent_Identity=38.3647798742138, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319407, Length=135, Percent_Identity=31.1111111111111, Blast_Score=72, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17157991, Length=159, Percent_Identity=35.8490566037736, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24641739, Length=159, Percent_Identity=35.8490566037736, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17738015, Length=153, Percent_Identity=36.6013071895425, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21357347, Length=149, Percent_Identity=34.8993288590604, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24656348, Length=153, Percent_Identity=33.9869281045752, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17864676, Length=153, Percent_Identity=33.9869281045752, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581278, Length=158, Percent_Identity=29.1139240506329, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20307; Mature: 20307

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVGDKLEAFTVVAAKPGFNNHEENGQSAFETVTEASFPGKWKIIYFYPKDFTFVCPTE
CCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IVEFAKLTKQFEERDAVLLGGSSDNEFVKLAWRREHKDLDKLNHYSFGDVKGELIDQLGV
HHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHCC
RDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRSPEEVLRILDGLQTDELCPCNRAVGGA
CCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
TL
CC
>Mature Secondary Structure
MKTVGDKLEAFTVVAAKPGFNNHEENGQSAFETVTEASFPGKWKIIYFYPKDFTFVCPTE
CCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IVEFAKLTKQFEERDAVLLGGSSDNEFVKLAWRREHKDLDKLNHYSFGDVKGELIDQLGV
HHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHCC
RDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRSPEEVLRILDGLQTDELCPCNRAVGGA
CCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
TL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7604044; 8596438; 9634230; 12218036 [H]