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The map label for this gene is glxR [H]

Identifier: 116689901

GI number: 116689901

Start: 2085691

End: 2086584

Strand: Direct

Name: glxR [H]

Synonym: Bcen2424_1880

Alternate gene names: 116689901

Gene position: 2085691-2086584 (Clockwise)

Preceding gene: 116689900

Following gene: 116689902

Centisome position: 59.87

GC content: 67.23

Gene sequence:

>894_bases
ATGGCAACCATCGGTTTCATCGGCCTCGGCATCATGGGCGCGCACATGGCGCGCAACCTGCTCAAGGGCGATCATCAACT
CGTCGTGAACGGCGCGTTCCCGATTCCGGACGACCTGCGCGGGAACGCGAAGGTCGTCGCGAACTCGACCGAAGTCGCGC
AGCACGCGGACATCATCATCTCGATGGTGCCGGACACGCCGGACGTGCGTAACGTGCTGTTCGCCGACGACGGCGTCGCG
AAAGGCCTGACGGCCGGCAAGCTCGTGATCGACATGAGCTCGATCTCGCCGCTCGACACGCAGGCGTTCGCGAAGCAGAT
CAACGCGCTCGGCTGCGACTACCTCGACGCGCCGGTGTCCGGCGGCGAAGTCGGCGCCCGCGAAGCGACGCTGACGATCA
TGGTCGGCGGCCCGGAGAAGGCGTTCGAACGCGCGAAGCCGCTGTTCGAGAAGATGGGCAAGAACATCACGCTCGTCGGC
GACAACGGCGCGGGCCAGACCTGCAAGGTCGCGAACCAGATCATCGTCGCGCTGAACATCGAGGCGGTCGGCGAAGCGCT
GCTGTTCGCCGCCCGCTCGGGCGCCGATCCGGAGCGCGTGCGCCAGGCGCTGATGGGCGGCTTCGCAGCGTCGCGCATCC
TCGAAGTACACGGTGCGCGGATGACCAAGCGCACGTTCGATCCGGGCTTCCGCATCGAGCTGCACCAGAAGGACCTGAAC
CTCGCGCTCGACGGCGCACGCAAGCTCGGCCTCGCGCTGCCGCACACCGCGAGCGCGCAGCAGCTGTTCAGCGTGTGCGC
ATCGCACGGCGGCAAGGCATGGGATCACTCGGCACTCGTGCGCGCGCTCGAGATCATGTCGAACTTCGAGATCGGCCAGA
CGCCGGCCGCGTAA

Upstream 100 bases:

>100_bases
TCGGCTGGCTGCAAAGCGTGGCCGGCTGCGCACCGGCCTCGGCGCGTCGCGCCGCCTGAATCGCACCCTTCCCGTTTTCA
GCCCCATAGGAGACTTTCAC

Downstream 100 bases:

>100_bases
CGCGGATGCCGCAACGCGCGTTTGTGCTGCGATCGCGGACGCGCGCGACGCATACACGCGATTCGGCCGCGGCCGGTCGC
ATCGATGCGCGATGCACGCG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPIPDDLRGNAKVVANSTEVAQHADIIISMVPDTPDVRNVLFADDGVA
KGLTAGKLVIDMSSISPLDTQAFAKQINALGCDYLDAPVSGGEVGAREATLTIMVGGPEKAFERAKPLFEKMGKNITLVG
DNGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA

Sequences:

>Translated_297_residues
MATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPIPDDLRGNAKVVANSTEVAQHADIIISMVPDTPDVRNVLFADDGVA
KGLTAGKLVIDMSSISPLDTQAFAKQINALGCDYLDAPVSGGEVGAREATLTIMVGGPEKAFERAKPLFEKMGKNITLVG
DNGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA
>Mature_296_residues
ATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPIPDDLRGNAKVVANSTEVAQHADIIISMVPDTPDVRNVLFADDGVAK
GLTAGKLVIDMSSISPLDTQAFAKQINALGCDYLDAPVSGGEVGAREATLTIMVGGPEKAFERAKPLFEKMGKNITLVGD
NGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLNL
ALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=305, Percent_Identity=31.1475409836066, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=26.9503546099291, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=65.0519031141868, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI145693186, Length=290, Percent_Identity=41.3793103448276, Blast_Score=228, Evalue=3e-61,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=34.8275862068965, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1789092, Length=289, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=287, Percent_Identity=32.404181184669, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24655230, Length=273, Percent_Identity=36.996336996337, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI19922568, Length=273, Percent_Identity=36.996336996337, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI28574115, Length=286, Percent_Identity=27.972027972028, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31241; Mature: 31110

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPIPDDLRGNAKVVANSTEVAQHADIII
CCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCHHHHHHCCEEE
SMVPDTPDVRNVLFADDGVAKGLTAGKLVIDMSSISPLDTQAFAKQINALGCDYLDAPVS
EECCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGAREATLTIMVGGPEKAFERAKPLFEKMGKNITLVGDNGAGQTCKVANQIIVALNI
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCEEEEEEEH
EAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCC
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA
EEECCHHHCCEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPIPDDLRGNAKVVANSTEVAQHADIII
CEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCHHHHHHCCEEE
SMVPDTPDVRNVLFADDGVAKGLTAGKLVIDMSSISPLDTQAFAKQINALGCDYLDAPVS
EECCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGAREATLTIMVGGPEKAFERAKPLFEKMGKNITLVGDNGAGQTCKVANQIIVALNI
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCEEEEEEEH
EAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCC
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA
EEECCHHHCCEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]