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The map label for this gene is trxA [H]

Identifier: 116689849

GI number: 116689849

Start: 2031362

End: 2031688

Strand: Direct

Name: trxA [H]

Synonym: Bcen2424_1828

Alternate gene names: 116689849

Gene position: 2031362-2031688 (Clockwise)

Preceding gene: 116689839

Following gene: 116689850

Centisome position: 58.31

GC content: 61.47

Gene sequence:

>327_bases
ATGAGCGAACAGATCAAACACATCAGCGACGCATCGTTCGAACAGGACGTCGTCAAGTCCGACAAGCCCGTACTCGTCGA
TTTCTGGGCCGAATGGTGCGGCCCGTGCAAGATGATCGCCCCGATCCTCGACGAAGTCGCGAAGGACTACGGCGACAAGC
TGCAGATCGCGAAGATCAACGTCGACGACAACCAGGCCACGCCCGCGAAATTCGGCGTGCGCGGCATCCCGACGCTGATC
CTGTTCAAGAACGGCGCGGCCGCCGCGCAGAAGGTCGGCGCGCTGTCGAAGTCGCAGCTCACCGCATTCCTGGACAGCCA
CCTGTAA

Upstream 100 bases:

>100_bases
AAAGGCGGAGTGACCTGCCGCAGCGGCCGGCAGCCTACGGCGGCCGGTACGCCGCAACGCGCAAGCAGGCAGTCCCCGAA
CCGTAAGAGGTATTGACCCA

Downstream 100 bases:

>100_bases
TACTGGCAGTTCCGCGGACGTGTTGTCAGTCGGCAACACGTCCGCCGTCAAGCCGCCGATCGCTCGCTCAAGCGCGAATC
GGGCTATGCTAGAATTAAAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSEQIKHISDASFEQDVVKSDKPVLVDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKINVDDNQATPAKFGVRGIPTLI
LFKNGAAAAQKVGALSKSQLTAFLDSHL

Sequences:

>Translated_108_residues
MSEQIKHISDASFEQDVVKSDKPVLVDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKINVDDNQATPAKFGVRGIPTLI
LFKNGAAAAQKVGALSKSQLTAFLDSHL
>Mature_107_residues
SEQIKHISDASFEQDVVKSDKPVLVDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKINVDDNQATPAKFGVRGIPTLIL
FKNGAAAAQKVGALSKSQLTAFLDSHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=43.010752688172, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=29, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=64.8148148148148, Blast_Score=155, Evalue=5e-40,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=39.1304347826087, Blast_Score=91, Evalue=2e-20,
Organism=Escherichia coli, GI87081747, Length=107, Percent_Identity=34.5794392523364, Blast_Score=69, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=112, Percent_Identity=34.8214285714286, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=40.2298850574713, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=40.2298850574713, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=38.1578947368421, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=103, Percent_Identity=27.1844660194175, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=87, Percent_Identity=39.0804597701149, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=77, Percent_Identity=38.961038961039, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=40.4255319148936, Blast_Score=74, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=41.1111111111111, Blast_Score=72, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=38.2978723404255, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=34.7826086956522, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=41.3333333333333, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=32.258064516129, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=37.1794871794872, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=37.1794871794872, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=30.8641975308642, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11759; Mature: 11627

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQIKHISDASFEQDVVKSDKPVLVDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKIN
CCCCHHHCCCCCHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEE
VDDNQATPAKFGVRGIPTLILFKNGAAAAQKVGALSKSQLTAFLDSHL
CCCCCCCCHHCCCCCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SEQIKHISDASFEQDVVKSDKPVLVDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKIN
CCCHHHCCCCCHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEE
VDDNQATPAKFGVRGIPTLILFKNGAAAAQKVGALSKSQLTAFLDSHL
CCCCCCCCHHCCCCCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]