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The map label for this gene is cobW [H]

Identifier: 116689678

GI number: 116689678

Start: 1840041

End: 1841129

Strand: Direct

Name: cobW [H]

Synonym: Bcen2424_1656

Alternate gene names: 116689678

Gene position: 1840041-1841129 (Clockwise)

Preceding gene: 116689672

Following gene: 116689679

Centisome position: 52.82

GC content: 68.14

Gene sequence:

>1089_bases
ATGACCCTACGCAAGCTTCCCGTCACGATCGTCACGGGCTTTCTCGGCAGCGGCAAGACGACGCTGATGCGCCACATCCT
GCAGCACGCCGAAGGCCGCCGCATCGCGGTGATCGTCAACGAATTCGGCGAACTCGGCATCGACGGCGAAATCCTCAAGG
GCTGCGGCATCGGCTGCGACGATGCCGACGGCGCGCAGGGCGAGGCATCGGGCCAGCTGTACGAACTCGCGAACGGCTGC
CTGTGCTGCACCGTGCAGGAAGAGTTCTATCCGGTGATGGAGGCGCTCGTCGAGCGCCGCGCGGACATCGACCACGTGCT
GATCGAGACGTCGGGCCTCGCGCTGCCGAAGCCGCTCGTGCAGGCCTTCAACTGGCCGACGATCCGCAACAGCTTCACGG
TCGACGCGGTCGTGACCGTCGTCGACGGGCCGGCCGCCGCGAGCGGCCAGTTCGCGGAAAACCCCCAGGCCGTCGACGCG
CAGCGCCGCGCCGATCCGAACCTCGATCACGAATCGCCGCTGCACGAACTGTTCGCCGATCAACTGTCGTCCGCCGATCT
CGTGATCGTGAACAAGGCCGACCTCGTGGGTGACGCCGAGTTCGCGCGGATCGAAACCGCGATCCGCGAAGAAATCCCGC
CGCAGGTGAAGATCGTGCGCGCGACGCGCGGCGAGCTCGACCTCGCGATGCTGCTCGGGCTGGACTCGGCCTCGGAGGAA
ACGATCCACCTGCGTCACGACCATCACGGCTCGGCCGACGACGGCGATCACGATCACCATCACGACGATTTCGACTCGGT
GGTGGTATCGGGCGACGCGGGCACGCGCGAAGCGACGATCGCCGCGCTGCAGCGCGTGGTCGAAGCGCACACGATCTACC
GCGCGAAAGGCTTCGCCGCGCTGCCCGGCGCGCCGATGCGGCTCGTGATCCAGGGTGTCGGCCGCCGCTTCGACAGCTAT
TTCGACCGCCGCTGGCAGGACGGCGAAACCCGCGCGAGCCGCTTCGTGCTGATCGGCGAGGATCTCGACGCGGCCGCGCT
GCAACGCGCGTTCGACGCCGCGTGCGCGGCCGAGCCGCAACAGGCGTAA

Upstream 100 bases:

>100_bases
GGATCGCGCGGCGAGCTTCCCGCGCACCGCCCGCTGAATTGCCGCGCCGCCACCGACGCGACGATCCCGTCCTGATTCCC
TCTTCGACACCGGACCTACC

Downstream 100 bases:

>100_bases
CGCACGATGCATCTGCTGCGCACCACGCCGGGCGGCTTCGTCGACGATACACAGGGCGTCGTCCGGATCGACCAGCAGCC
GGCCGACATCGTGATCCTGA

Product: cobalamin biosynthesis protein CobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MTLRKLPVTIVTGFLGSGKTTLMRHILQHAEGRRIAVIVNEFGELGIDGEILKGCGIGCDDADGAQGEASGQLYELANGC
LCCTVQEEFYPVMEALVERRADIDHVLIETSGLALPKPLVQAFNWPTIRNSFTVDAVVTVVDGPAAASGQFAENPQAVDA
QRRADPNLDHESPLHELFADQLSSADLVIVNKADLVGDAEFARIETAIREEIPPQVKIVRATRGELDLAMLLGLDSASEE
TIHLRHDHHGSADDGDHDHHHDDFDSVVVSGDAGTREATIAALQRVVEAHTIYRAKGFAALPGAPMRLVIQGVGRRFDSY
FDRRWQDGETRASRFVLIGEDLDAAALQRAFDAACAAEPQQA

Sequences:

>Translated_362_residues
MTLRKLPVTIVTGFLGSGKTTLMRHILQHAEGRRIAVIVNEFGELGIDGEILKGCGIGCDDADGAQGEASGQLYELANGC
LCCTVQEEFYPVMEALVERRADIDHVLIETSGLALPKPLVQAFNWPTIRNSFTVDAVVTVVDGPAAASGQFAENPQAVDA
QRRADPNLDHESPLHELFADQLSSADLVIVNKADLVGDAEFARIETAIREEIPPQVKIVRATRGELDLAMLLGLDSASEE
TIHLRHDHHGSADDGDHDHHHDDFDSVVVSGDAGTREATIAALQRVVEAHTIYRAKGFAALPGAPMRLVIQGVGRRFDSY
FDRRWQDGETRASRFVLIGEDLDAAALQRAFDAACAAEPQQA
>Mature_361_residues
TLRKLPVTIVTGFLGSGKTTLMRHILQHAEGRRIAVIVNEFGELGIDGEILKGCGIGCDDADGAQGEASGQLYELANGCL
CCTVQEEFYPVMEALVERRADIDHVLIETSGLALPKPLVQAFNWPTIRNSFTVDAVVTVVDGPAAASGQFAENPQAVDAQ
RRADPNLDHESPLHELFADQLSSADLVIVNKADLVGDAEFARIETAIREEIPPQVKIVRATRGELDLAMLLGLDSASEET
IHLRHDHHGSADDGDHDHHHDDFDSVVVSGDAGTREATIAALQRVVEAHTIYRAKGFAALPGAPMRLVIQGVGRRFDSYF
DRRWQDGETRASRFVLIGEDLDAAALQRAFDAACAAEPQQA

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=376, Percent_Identity=28.1914893617021, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI148727351, Length=376, Percent_Identity=28.1914893617021, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI33469141, Length=376, Percent_Identity=27.9255319148936, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI146231952, Length=375, Percent_Identity=28.5333333333333, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI223941779, Length=365, Percent_Identity=27.1232876712329, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI223941776, Length=377, Percent_Identity=26.790450928382, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI119120938, Length=153, Percent_Identity=35.9477124183007, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI87082430, Length=362, Percent_Identity=28.7292817679558, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1788499, Length=188, Percent_Identity=31.9148936170213, Blast_Score=91, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324356, Length=385, Percent_Identity=25.974025974026, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 39199; Mature: 39068

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRKLPVTIVTGFLGSGKTTLMRHILQHAEGRRIAVIVNEFGELGIDGEILKGCGIGCD
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECHHCCCCCCHHHHHCCCCCC
DADGAQGEASGQLYELANGCLCCTVQEEFYPVMEALVERRADIDHVLIETSGLALPKPLV
CCCCCCCCCCCHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
QAFNWPTIRNSFTVDAVVTVVDGPAAASGQFAENPQAVDAQRRADPNLDHESPLHELFAD
HHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHCHHHHCCCCCCCCCHHHHHHHH
QLSSADLVIVNKADLVGDAEFARIETAIREEIPPQVKIVRATRGELDLAMLLGLDSASEE
HCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCC
TIHLRHDHHGSADDGDHDHHHDDFDSVVVSGDAGTREATIAALQRVVEAHTIYRAKGFAA
EEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
LPGAPMRLVIQGVGRRFDSYFDRRWQDGETRASRFVLIGEDLDAAALQRAFDAACAAEPQ
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
QA
CC
>Mature Secondary Structure 
TLRKLPVTIVTGFLGSGKTTLMRHILQHAEGRRIAVIVNEFGELGIDGEILKGCGIGCD
CCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECHHCCCCCCHHHHHCCCCCC
DADGAQGEASGQLYELANGCLCCTVQEEFYPVMEALVERRADIDHVLIETSGLALPKPLV
CCCCCCCCCCCHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
QAFNWPTIRNSFTVDAVVTVVDGPAAASGQFAENPQAVDAQRRADPNLDHESPLHELFAD
HHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHCHHHHCCCCCCCCCHHHHHHHH
QLSSADLVIVNKADLVGDAEFARIETAIREEIPPQVKIVRATRGELDLAMLLGLDSASEE
HCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCC
TIHLRHDHHGSADDGDHDHHHDDFDSVVVSGDAGTREATIAALQRVVEAHTIYRAKGFAA
EEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
LPGAPMRLVIQGVGRRFDSYFDRRWQDGETRASRFVLIGEDLDAAALQRAFDAACAAEPQ
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
QA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]