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The map label for this gene is dmlR [H]

Identifier: 116689492

GI number: 116689492

Start: 1623717

End: 1624625

Strand: Direct

Name: dmlR [H]

Synonym: Bcen2424_1470

Alternate gene names: 116689492

Gene position: 1623717-1624625 (Clockwise)

Preceding gene: 116689488

Following gene: 116689493

Centisome position: 46.61

GC content: 70.19

Gene sequence:

>909_bases
ATGACGCTGATCGACGATTTCCCCGCGCTCGATACGTTCGCGCGGATCGTGTCGGCCGGCAGCCTGTCGGCGGCGGCGCG
CGAGCTCGACCTGTCGTTGTCGGTCGTCAGCAAGCGGCTCGCGCATCTCGAGTCGCGGCTCGGCGTGCGCCTGCTGCACC
GGACGACGCGGCAGCAGACGCTCACCGACGACGGCGCGCAGTTTCATGCGCAGGTCCTGCGCATCCTGGCCGAAGTCGAG
CATGCGGAAACGCTGATGCGCGACCGCCGCGGCACGGTCAGCGGCGTGCTGCGCGTGACGGCGCCCGGCGAACTCGGCCG
CCTGCGAATCGCGCCGCTCGTCGCGGCATTTCAGCAGCGGCATCCGCAATTGACCGTGCAGTTGATGCTGACCGATGCGG
TCGTCGATCTGCTCGCAGCCGACATCGACGTCGCCGTGCGGATCGGCAATCTTGCCGATTCGACGATGATCGCGCGCGAG
CTGGCGCCGAATCACCGCGTGCTGTGCGCGTCGCCGGGCTATCTCGCGGCGCACGGCTGGCCGGCCCATCCGGCCGAGCT
GCGTGCGCATCGATGCATCGTGATGGGCGACCAGCCGCGTGCCGAATGGCGGTTCGATGGCGCGCAAGGCGGCGTGGCGG
TCGAGGTGACGGCCGCGCTGCTGACCAACGACGGCGGCGCGGCGCGCACGCTGGCGCTCGAAGGCGCGGGCATTGCGTTG
AAGTCGATCTGGGACGTCGGCGCCGATCTCGACGCCGGCCGGCTCGTGCGCGTGCTGCCGGCCTTCGAGGCATCCGCCGC
GCCGTTGCATGCCGTTTATCCCGGCGCTCGCCATGTGCCGTTGCGGGTGCGGACATTCGTCGATTTCCTGCGCGAGCAGT
TGCGGGACGCGTGGCGTCGCCACGATTGA

Upstream 100 bases:

>100_bases
ACGCGGAACAGGTATGGTAGGTTTCCGTTCTGAATGCAAATACGGGAAAGAAGCGAATGGATTCTTCGAAAAAAGGAAAG
GTTGGGATGAGGCGGGCGCC

Downstream 100 bases:

>100_bases
ACCCGTCTCGGGTGCTGGGCCGGGGCGCGTGGCGCCCCGTCATTCCGAAGCGGTTTACAATCGTTTGCATCGGGCGCCGC
AAGCGTTGTCCCGCGCGTCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTLIDDFPALDTFARIVSAGSLSAAARELDLSLSVVSKRLAHLESRLGVRLLHRTTRQQTLTDDGAQFHAQVLRILAEVE
HAETLMRDRRGTVSGVLRVTAPGELGRLRIAPLVAAFQQRHPQLTVQLMLTDAVVDLLAADIDVAVRIGNLADSTMIARE
LAPNHRVLCASPGYLAAHGWPAHPAELRAHRCIVMGDQPRAEWRFDGAQGGVAVEVTAALLTNDGGAARTLALEGAGIAL
KSIWDVGADLDAGRLVRVLPAFEASAAPLHAVYPGARHVPLRVRTFVDFLREQLRDAWRRHD

Sequences:

>Translated_302_residues
MTLIDDFPALDTFARIVSAGSLSAAARELDLSLSVVSKRLAHLESRLGVRLLHRTTRQQTLTDDGAQFHAQVLRILAEVE
HAETLMRDRRGTVSGVLRVTAPGELGRLRIAPLVAAFQQRHPQLTVQLMLTDAVVDLLAADIDVAVRIGNLADSTMIARE
LAPNHRVLCASPGYLAAHGWPAHPAELRAHRCIVMGDQPRAEWRFDGAQGGVAVEVTAALLTNDGGAARTLALEGAGIAL
KSIWDVGADLDAGRLVRVLPAFEASAAPLHAVYPGARHVPLRVRTFVDFLREQLRDAWRRHD
>Mature_301_residues
TLIDDFPALDTFARIVSAGSLSAAARELDLSLSVVSKRLAHLESRLGVRLLHRTTRQQTLTDDGAQFHAQVLRILAEVEH
AETLMRDRRGTVSGVLRVTAPGELGRLRIAPLVAAFQQRHPQLTVQLMLTDAVVDLLAADIDVAVRIGNLADSTMIAREL
APNHRVLCASPGYLAAHGWPAHPAELRAHRCIVMGDQPRAEWRFDGAQGGVAVEVTAALLTNDGGAARTLALEGAGIALK
SIWDVGADLDAGRLVRVLPAFEASAAPLHAVYPGARHVPLRVRTFVDFLREQLRDAWRRHD

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=300, Percent_Identity=36.3333333333333, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1786401, Length=294, Percent_Identity=34.6938775510204, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789440, Length=283, Percent_Identity=33.9222614840989, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1789639, Length=282, Percent_Identity=30.4964539007092, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787128, Length=285, Percent_Identity=29.4736842105263, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI145693193, Length=293, Percent_Identity=31.3993174061433, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787589, Length=287, Percent_Identity=26.8292682926829, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1789173, Length=237, Percent_Identity=24.8945147679325, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787601, Length=179, Percent_Identity=25.6983240223464, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788706, Length=298, Percent_Identity=23.1543624161074, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788481, Length=140, Percent_Identity=29.2857142857143, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32788; Mature: 32657

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIDDFPALDTFARIVSAGSLSAAARELDLSLSVVSKRLAHLESRLGVRLLHRTTRQQT
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTDDGAQFHAQVLRILAEVEHAETLMRDRRGTVSGVLRVTAPGELGRLRIAPLVAAFQQR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHC
HPQLTVQLMLTDAVVDLLAADIDVAVRIGNLADSTMIARELAPNHRVLCASPGYLAAHGW
CCCEEEEEHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCCEEEECCC
PAHPAELRAHRCIVMGDQPRAEWRFDGAQGGVAVEVTAALLTNDGGAARTLALEGAGIAL
CCCHHHHHHCEEEEECCCCCCCEEECCCCCCEEEEEEEEEEECCCCCEEEEEECCCCCHH
KSIWDVGADLDAGRLVRVLPAFEASAAPLHAVYPGARHVPLRVRTFVDFLREQLRDAWRR
HHHHHCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHC
HD
CC
>Mature Secondary Structure 
TLIDDFPALDTFARIVSAGSLSAAARELDLSLSVVSKRLAHLESRLGVRLLHRTTRQQT
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTDDGAQFHAQVLRILAEVEHAETLMRDRRGTVSGVLRVTAPGELGRLRIAPLVAAFQQR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHC
HPQLTVQLMLTDAVVDLLAADIDVAVRIGNLADSTMIARELAPNHRVLCASPGYLAAHGW
CCCEEEEEHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCCEEEECCC
PAHPAELRAHRCIVMGDQPRAEWRFDGAQGGVAVEVTAALLTNDGGAARTLALEGAGIAL
CCCHHHHHHCEEEEECCCCCCCEEECCCCCCEEEEEEEEEEECCCCCEEEEEECCCCCHH
KSIWDVGADLDAGRLVRVLPAFEASAAPLHAVYPGARHVPLRVRTFVDFLREQLRDAWRR
HHHHHCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHC
HD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]