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The map label for this gene is livM [H]

Identifier: 116689437

GI number: 116689437

Start: 1561129

End: 1562358

Strand: Direct

Name: livM [H]

Synonym: Bcen2424_1415

Alternate gene names: 116689437

Gene position: 1561129-1562358 (Clockwise)

Preceding gene: 116689436

Following gene: 116689438

Centisome position: 44.81

GC content: 74.8

Gene sequence:

>1230_bases
ATGCATAGCCGCGCACTGGCCGGATGCATGCGCTGGGCGCTGTTCGCCGCGTGCGTCGCGCTGCCCGCGTGGCTGTGGCC
GCATGGTGCGGTGCTCGGCTATCTCGCGCAGACGGCCGCGCTCGTCGTGCTCGCGCTGTCTTACAACCTGCAGCTCGGCA
CGACCGGGCTGCTGTCGTTCGGGCACGCGGCGTTTGCAGGCCTCGGCGCGTTCGCGGCCGCCCACTGGTTCAACCACATC
GGCGGCCCGCTGCCGCTGCTGCCGCTCGTCGGCGGCATGGCCGGCGCGGGCTTCGGGTTCGTCGCCGGGCTGCTGGCGAC
GCGCCGCTCGGGCACCGCGTTCGCGATGATCACGCTCGGGCTCGGCGAATGCGTCGCGGCCGCCGCGTGGAGCGTGCCCG
CGTGGTTCGGCGGAATCGGCGGCGTGTCGATCGACCGGGCAAGCGGCGCGCCGTGGGGCAACGGGTATTTCGGCGCGCCG
GCCCACGCGTATGCGGTGATCGCCGCGTGGTGCGTCGTGTCGGCGGCGGCCATGCATGTGCTGACGCGCACGCCGCTCGC
GCGGCTCGCGAACGCGGTGCGCGACAACCCGGCGCGCGTCGCGGCGCTCGGCACCGATCCGCGCCGCGTGCGGCTCGCGA
TGGTCACCTGCGCATCGTTCTTCGCCGGCGTCGCCGGCACGCTGACGCTGATCGACGTCGAACTCGCGACGCCCGACAGC
GTGTCGATGGCGCGCTCGGCGACCGTGCTGATCGCCGCGGTGATCGGCGGCACCGGTGCGTTCTTCGGGCCGGCGGCCGG
CGCGGCCGTGCTGACCGCGCTGAGTATCGGCGTCGCGGGCGTGTCGCGTGCGTGGGCGCTGTATCTGGGCGTGCTGTTCG
TCGCGGTCGTCGTGGCCGCGCCGGGCGGGATCGCCGGCATCGCGCGGGCGCTCGCGCATGCATTGCGGCGCGATGTACCG
GCGATCGAGCGCTGGCGGGTGCTGTGCGCGATCGGTGCGTGCGTGTTCTGGGGCGTCGCGATCGTCTGCGCGGCCGAGCT
CGGCTATGCGTGGCGCTTCGCGCAGGACGACGGCACGGGCCTCGCGTTCGGCGCATGGGGCATCGACGCCGATACGCCGG
TCGGCTGGGCCGTCGCGGCTTCGGCGGCCGGCATCGGCACGCTGCTGTGGGGCTGGCGCGCGCGGCTCGGGCACGGCGCG
GCGGTCGCCACGCAGGAGGACGCACGATGA

Upstream 100 bases:

>100_bases
GCCGCGGTGTCGATCGCCCAACTGGCGCCGCTGGTGCCGTACCTGCTGCTCGTCGCGGTGCTGGTCGCGCGGCCGCGCGG
GCTGTTCGGCGAGCGTGTCG

Downstream 100 bases:

>100_bases
ACGGCAACGCGATCGCGCTGCACGGCGTGGTGCAGCGCTTCGGCGCGCAGACCGTGCTCGACGGCGTCGATCTGAGCATC
GCGGCCGGTGAGCGCCACGC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MHSRALAGCMRWALFAACVALPAWLWPHGAVLGYLAQTAALVVLALSYNLQLGTTGLLSFGHAAFAGLGAFAAAHWFNHI
GGPLPLLPLVGGMAGAGFGFVAGLLATRRSGTAFAMITLGLGECVAAAAWSVPAWFGGIGGVSIDRASGAPWGNGYFGAP
AHAYAVIAAWCVVSAAAMHVLTRTPLARLANAVRDNPARVAALGTDPRRVRLAMVTCASFFAGVAGTLTLIDVELATPDS
VSMARSATVLIAAVIGGTGAFFGPAAGAAVLTALSIGVAGVSRAWALYLGVLFVAVVVAAPGGIAGIARALAHALRRDVP
AIERWRVLCAIGACVFWGVAIVCAAELGYAWRFAQDDGTGLAFGAWGIDADTPVGWAVAASAAGIGTLLWGWRARLGHGA
AVATQEDAR

Sequences:

>Translated_409_residues
MHSRALAGCMRWALFAACVALPAWLWPHGAVLGYLAQTAALVVLALSYNLQLGTTGLLSFGHAAFAGLGAFAAAHWFNHI
GGPLPLLPLVGGMAGAGFGFVAGLLATRRSGTAFAMITLGLGECVAAAAWSVPAWFGGIGGVSIDRASGAPWGNGYFGAP
AHAYAVIAAWCVVSAAAMHVLTRTPLARLANAVRDNPARVAALGTDPRRVRLAMVTCASFFAGVAGTLTLIDVELATPDS
VSMARSATVLIAAVIGGTGAFFGPAAGAAVLTALSIGVAGVSRAWALYLGVLFVAVVVAAPGGIAGIARALAHALRRDVP
AIERWRVLCAIGACVFWGVAIVCAAELGYAWRFAQDDGTGLAFGAWGIDADTPVGWAVAASAAGIGTLLWGWRARLGHGA
AVATQEDAR
>Mature_409_residues
MHSRALAGCMRWALFAACVALPAWLWPHGAVLGYLAQTAALVVLALSYNLQLGTTGLLSFGHAAFAGLGAFAAAHWFNHI
GGPLPLLPLVGGMAGAGFGFVAGLLATRRSGTAFAMITLGLGECVAAAAWSVPAWFGGIGGVSIDRASGAPWGNGYFGAP
AHAYAVIAAWCVVSAAAMHVLTRTPLARLANAVRDNPARVAALGTDPRRVRLAMVTCASFFAGVAGTLTLIDVELATPDS
VSMARSATVLIAAVIGGTGAFFGPAAGAAVLTALSIGVAGVSRAWALYLGVLFVAVVVAAPGGIAGIARALAHALRRDVP
AIERWRVLCAIGACVFWGVAIVCAAELGYAWRFAQDDGTGLAFGAWGIDADTPVGWAVAASAAGIGTLLWGWRARLGHGA
AVATQEDAR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=326, Percent_Identity=28.2208588957055, Blast_Score=88, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 41391; Mature: 41391

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSRALAGCMRWALFAACVALPAWLWPHGAVLGYLAQTAALVVLALSYNLQLGTTGLLSF
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHH
GHAAFAGLGAFAAAHWFNHIGGPLPLLPLVGGMAGAGFGFVAGLLATRRSGTAFAMITLG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEHH
LGECVAAAAWSVPAWFGGIGGVSIDRASGAPWGNGYFGAPAHAYAVIAAWCVVSAAAMHV
HHHHHHHHHHCCHHHHCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LTRTPLARLANAVRDNPARVAALGTDPRRVRLAMVTCASFFAGVAGTLTLIDVELATPDS
HHHCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCC
VSMARSATVLIAAVIGGTGAFFGPAAGAAVLTALSIGVAGVSRAWALYLGVLFVAVVVAA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PGGIAGIARALAHALRRDVPAIERWRVLCAIGACVFWGVAIVCAAELGYAWRFAQDDGTG
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCE
LAFGAWGIDADTPVGWAVAASAAGIGTLLWGWRARLGHGAAVATQEDAR
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure
MHSRALAGCMRWALFAACVALPAWLWPHGAVLGYLAQTAALVVLALSYNLQLGTTGLLSF
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHH
GHAAFAGLGAFAAAHWFNHIGGPLPLLPLVGGMAGAGFGFVAGLLATRRSGTAFAMITLG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEHH
LGECVAAAAWSVPAWFGGIGGVSIDRASGAPWGNGYFGAPAHAYAVIAAWCVVSAAAMHV
HHHHHHHHHHCCHHHHCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LTRTPLARLANAVRDNPARVAALGTDPRRVRLAMVTCASFFAGVAGTLTLIDVELATPDS
HHHCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCC
VSMARSATVLIAAVIGGTGAFFGPAAGAAVLTALSIGVAGVSRAWALYLGVLFVAVVVAA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PGGIAGIARALAHALRRDVPAIERWRVLCAIGACVFWGVAIVCAAELGYAWRFAQDDGTG
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCE
LAFGAWGIDADTPVGWAVAASAAGIGTLLWGWRARLGHGAAVATQEDAR
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]