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The map label for this gene is lspA

Identifier: 116624430

GI number: 116624430

Start: 6711433

End: 6711927

Strand: Reverse

Name: lspA

Synonym: Acid_5352

Alternate gene names: 116624430

Gene position: 6711927-6711433 (Counterclockwise)

Preceding gene: 116624431

Following gene: 116624429

Centisome position: 67.35

GC content: 56.36

Gene sequence:

>495_bases
ATGCCTGACCTGCGGTGGAAAGCTTACGGAGTCGCGGCGCTGATCTTCGCGCTGGACCGCTTCACCAAGTGGCTGGTGGA
AACCAACGTCTCCGTTATGGACACTTACCACGTCATCCCCGGCTTCTTCGATATCGTGCACTCGGAGAATCGCGGCGTAG
CTTTCGGCATCCTCAACGATTCCACCAGCGAATGGCGCACCACGATATTAGTCGTGCTCGCGGGCGCGGCCGTTATCTTT
ATCGCGGCTATGCTTTGGAACGCGCAACGGCTCGATCGTGCATCCTTCTGGGGTCTTTCCCTCATTTTAGGCGGCGCCGC
CGGCAATGTCTTTGATCGGGCAATGTTTGGAAAAGTTACTGACTTCCTGGATTTGTACTATCGCGACTATCACTGGCATA
CGTTCAACGTAGCGGACTCGGCGATCGTGGTCGGCAGTTGTTTGCTGCTGATCGATCTGCTGCGGCCCAAACGGCAGGCG
GCCAATGTTTCCTAA

Upstream 100 bases:

>100_bases
AAGTGCGAGCGCTGCTGGAAGTACAGCAAGGAAGTGGGCACAGACCCTGTTCTTCCAACCCTCTGCGCCCGGTGCGCCAA
GGCGGTACACGAGATACTCA

Downstream 100 bases:

>100_bases
GCTATTTCATCTTCCTATCCTCGACTCCGATGTCCATACCTATGGCGTATTGGTTGCCATCGCGTTTCTGGCCGCGCTAT
GGCTGGCCGGACGCCTCGCG

Product: signal peptidase II

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MPDLRWKAYGVAALIFALDRFTKWLVETNVSVMDTYHVIPGFFDIVHSENRGVAFGILNDSTSEWRTTILVVLAGAAVIF
IAAMLWNAQRLDRASFWGLSLILGGAAGNVFDRAMFGKVTDFLDLYYRDYHWHTFNVADSAIVVGSCLLLIDLLRPKRQA
ANVS

Sequences:

>Translated_164_residues
MPDLRWKAYGVAALIFALDRFTKWLVETNVSVMDTYHVIPGFFDIVHSENRGVAFGILNDSTSEWRTTILVVLAGAAVIF
IAAMLWNAQRLDRASFWGLSLILGGAAGNVFDRAMFGKVTDFLDLYYRDYHWHTFNVADSAIVVGSCLLLIDLLRPKRQA
ANVS
>Mature_163_residues
PDLRWKAYGVAALIFALDRFTKWLVETNVSVMDTYHVIPGFFDIVHSENRGVAFGILNDSTSEWRTTILVVLAGAAVIFI
AAMLWNAQRLDRASFWGLSLILGGAAGNVFDRAMFGKVTDFLDLYYRDYHWHTFNVADSAIVVGSCLLLIDLLRPKRQAA
NVS

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=155, Percent_Identity=34.1935483870968, Blast_Score=86, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_SOLUE (Q01VL4)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_826586.1
- STRING:   Q01VL4
- MEROPS:   A08.001
- GeneID:   4426418
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_5352
- NMPDR:   fig|234267.9.peg.5082
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   EYYWPAF
- PhylomeDB:   Q01VL4
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18374; Mature: 18243

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 112-112 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

HASH(0x1d27a64c)-; HASH(0x1c4ea070)-; HASH(0x1cbdc044)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLRWKAYGVAALIFALDRFTKWLVETNVSVMDTYHVIPGFFDIVHSENRGVAFGILND
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
STSEWRTTILVVLAGAAVIFIAAMLWNAQRLDRASFWGLSLILGGAAGNVFDRAMFGKVT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DFLDLYYRDYHWHTFNVADSAIVVGSCLLLIDLLRPKRQAANVS
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHCCHHHCCCCH
>Mature Secondary Structure 
PDLRWKAYGVAALIFALDRFTKWLVETNVSVMDTYHVIPGFFDIVHSENRGVAFGILND
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
STSEWRTTILVVLAGAAVIFIAAMLWNAQRLDRASFWGLSLILGGAAGNVFDRAMFGKVT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DFLDLYYRDYHWHTFNVADSAIVVGSCLLLIDLLRPKRQAANVS
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHCCHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA