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The map label for this gene is kbl [C]

Identifier: 116624248

GI number: 116624248

Start: 6490792

End: 6491982

Strand: Reverse

Name: kbl [C]

Synonym: Acid_5166

Alternate gene names: 116624248

Gene position: 6491982-6490792 (Counterclockwise)

Preceding gene: 116624249

Following gene: 116624247

Centisome position: 65.14

GC content: 64.15

Gene sequence:

>1191_bases
ATGTCCAATCCGCTGTCCTATCTTCATGATCAGCTGGAAGCCTGGCGCGCCGAGGGCACCTATCAGCGCCTGCGCATTCT
GCAATCGGCGAGCGCGGCCGAGGCAGAATTCGACGGCAAGCAGGTGATCAATCTCGCCTCCAACAACTACCTTGGCCTGA
CGACTCATCCGAAGCTCCGCGAAGCTGCGTTGGAAGCAGTGCGCAAGTACGGCGTGGGGTCGGGCGCGGTGCGTACCATC
TCCGGCACCATGACGCTGCACATGCAACTGGAGGAGCGCATCGCGGCCTTCAAGAACGTGGAGGCGTGCGTAGTATTCCA
ATCGGGATTCGCCGCCAACGCGGGCACCGTTTCCGCGATTCTCACGCCGGAAGACCACATCATCAGCGACGAATTGAACC
ACGCCAGCATCATCGATGGCTGCCGCCTTTCGCGCGCCAAGATCCACGTCTTCGCCCACAAGGACGTGGCCGCCGCCGAG
AAGATTCTCGCCGAACTGGCGCCGCTCCCGGGCCGCAAGCTGTTGATTACCGACGGCGTTTTCTCGATGGATGGCGACAT
CGGCCCGCTGCCGGGCCTGGCCGGCGCGGCGGAAAAACACGGCGCCATCATGATGGTGGATGACGCGCATGCTTCGGGCG
TGCTGGGGCGCAACGGACGCGGCACGATCGACCACTTCGGCGTTCACGGACGGGTCCACGTGCAGGTGGGGACGTTGTCG
AAGGCTATCGGGGTGCTTGGCGGCTACGTCTGCGGCAGCCGCGACCTGATCGAGTTTCTGTATCATCGCGCGCGCCCCTT
CCTGTTTTCCACCTCGCATCCGCCGGCTGTCGCCGCCGCTTGTCTGGCCGCGTTCGATGTGCTGGAGCAGGAGCCCGAGC
GCATCGAACAGCTTTGGGACAACACGCGCTATTTCAAGAAGGGATTGCAGGAGGCCGGTTTCAACACCGGCATCAGCGAG
ACGCCGATCACGCCGGTGATCGTCGGCGAGGCCGCGCTCGCACACCGGCTTTCGCGCGAACTCTTCGACGAGGGAGTGCT
GGCCACCGGCATCGGGTTCCCGACGGTCGCGAAGGGAAAGGCGCGGGTGCGCACGATTGTGGCGTCCACGCACACGAAGG
CGGAGTTGGATCAGGCGCTGGAGGCGTTCCGCAAGGTCGGGAAGAAGCTCGGGATACTCCAAGTGCGGTAG

Upstream 100 bases:

>100_bases
CACGATCTTTTTATCGGCGAAGTGATGCATGTTACGGTTCGCGAGGGCAATCCATTGCTTTATTTCGCTAGCAGTTACCG
GCATTTATAGGGAGACCGCA

Downstream 100 bases:

>100_bases
CGTGAAGGAAGGACGCTATGCGTGCAGCTATTTTGCACTCGCCCGGATCGCCGCTGGAAATTGAGCAGGTGGCGGAGCCC
TCACTCGGGGCAGGGCAGGT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSNPLSYLHDQLEAWRAEGTYQRLRILQSASAAEAEFDGKQVINLASNNYLGLTTHPKLREAALEAVRKYGVGSGAVRTI
SGTMTLHMQLEERIAAFKNVEACVVFQSGFAANAGTVSAILTPEDHIISDELNHASIIDGCRLSRAKIHVFAHKDVAAAE
KILAELAPLPGRKLLITDGVFSMDGDIGPLPGLAGAAEKHGAIMMVDDAHASGVLGRNGRGTIDHFGVHGRVHVQVGTLS
KAIGVLGGYVCGSRDLIEFLYHRARPFLFSTSHPPAVAAACLAAFDVLEQEPERIEQLWDNTRYFKKGLQEAGFNTGISE
TPITPVIVGEAALAHRLSRELFDEGVLATGIGFPTVAKGKARVRTIVASTHTKAELDQALEAFRKVGKKLGILQVR

Sequences:

>Translated_396_residues
MSNPLSYLHDQLEAWRAEGTYQRLRILQSASAAEAEFDGKQVINLASNNYLGLTTHPKLREAALEAVRKYGVGSGAVRTI
SGTMTLHMQLEERIAAFKNVEACVVFQSGFAANAGTVSAILTPEDHIISDELNHASIIDGCRLSRAKIHVFAHKDVAAAE
KILAELAPLPGRKLLITDGVFSMDGDIGPLPGLAGAAEKHGAIMMVDDAHASGVLGRNGRGTIDHFGVHGRVHVQVGTLS
KAIGVLGGYVCGSRDLIEFLYHRARPFLFSTSHPPAVAAACLAAFDVLEQEPERIEQLWDNTRYFKKGLQEAGFNTGISE
TPITPVIVGEAALAHRLSRELFDEGVLATGIGFPTVAKGKARVRTIVASTHTKAELDQALEAFRKVGKKLGILQVR
>Mature_395_residues
SNPLSYLHDQLEAWRAEGTYQRLRILQSASAAEAEFDGKQVINLASNNYLGLTTHPKLREAALEAVRKYGVGSGAVRTIS
GTMTLHMQLEERIAAFKNVEACVVFQSGFAANAGTVSAILTPEDHIISDELNHASIIDGCRLSRAKIHVFAHKDVAAAEK
ILAELAPLPGRKLLITDGVFSMDGDIGPLPGLAGAAEKHGAIMMVDDAHASGVLGRNGRGTIDHFGVHGRVHVQVGTLSK
AIGVLGGYVCGSRDLIEFLYHRARPFLFSTSHPPAVAAACLAAFDVLEQEPERIEQLWDNTRYFKKGLQEAGFNTGISET
PITPVIVGEAALAHRLSRELFDEGVLATGIGFPTVAKGKARVRTIVASTHTKAELDQALEAFRKVGKKLGILQVR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=389, Percent_Identity=40.3598971722365, Blast_Score=299, Evalue=4e-81,
Organism=Homo sapiens, GI284448556, Length=415, Percent_Identity=37.8313253012048, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI4758668, Length=374, Percent_Identity=34.4919786096257, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI119220554, Length=377, Percent_Identity=33.42175066313, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI83977442, Length=391, Percent_Identity=31.4578005115089, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI83977440, Length=391, Percent_Identity=31.4578005115089, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI83977444, Length=391, Percent_Identity=31.4578005115089, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI4502025, Length=359, Percent_Identity=33.7047353760446, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI40316939, Length=359, Percent_Identity=33.7047353760446, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI5454084, Length=380, Percent_Identity=28.4210526315789, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1790046, Length=389, Percent_Identity=43.4447300771208, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=36.3636363636364, Blast_Score=216, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71994529, Length=392, Percent_Identity=40.8163265306122, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=32.7027027027027, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17560912, Length=364, Percent_Identity=29.6703296703297, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=364, Percent_Identity=29.6703296703297, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71982617, Length=381, Percent_Identity=25.7217847769029, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982625, Length=381, Percent_Identity=25.7217847769029, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=32.3369565217391, Blast_Score=195, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6320438, Length=415, Percent_Identity=30.8433734939759, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6323954, Length=258, Percent_Identity=30.6201550387597, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24662918, Length=391, Percent_Identity=41.9437340153453, Blast_Score=314, Evalue=8e-86,
Organism=Drosophila melanogaster, GI17136286, Length=374, Percent_Identity=33.1550802139037, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=34.6478873239437, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24653280, Length=387, Percent_Identity=29.1989664082687, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24653276, Length=387, Percent_Identity=29.1989664082687, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24653278, Length=387, Percent_Identity=29.1989664082687, Blast_Score=161, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42551; Mature: 42420

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLSYLHDQLEAWRAEGTYQRLRILQSASAAEAEFDGKQVINLASNNYLGLTTHPKLR
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHCCCCCHHEEEECCCCEEEECCCCHHH
EAALEAVRKYGVGSGAVRTISGTMTLHMQLEERIAAFKNVEACVVFQSGFAANAGTVSAI
HHHHHHHHHHCCCCCCEEEEECEEEEEEEHHHHHHHHCCCCEEEEEECCCCCCCCCEEEE
LTPEDHIISDELNHASIIDGCRLSRAKIHVFAHKDVAAAEKILAELAPLPGRKLLITDGV
ECCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCE
FSMDGDIGPLPGLAGAAEKHGAIMMVDDAHASGVLGRNGRGTIDHFGVHGRVHVQVGTLS
EECCCCCCCCCCCCCCHHHCCEEEEEECCCCCCCCCCCCCCCHHCCCCCCEEEEEECHHH
KAIGVLGGYVCGSRDLIEFLYHRARPFLFSTSHPPAVAAACLAAFDVLEQEPERIEQLWD
HHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHC
NTRYFKKGLQEAGFNTGISETPITPVIVGEAALAHRLSRELFDEGVLATGIGFPTVAKGK
CHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCEEECCCCCCCCCCH
ARVRTIVASTHTKAELDQALEAFRKVGKKLGILQVR
HHHEEHHHCCCCHHHHHHHHHHHHHHHHHCCCEECC
>Mature Secondary Structure 
SNPLSYLHDQLEAWRAEGTYQRLRILQSASAAEAEFDGKQVINLASNNYLGLTTHPKLR
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHCCCCCHHEEEECCCCEEEECCCCHHH
EAALEAVRKYGVGSGAVRTISGTMTLHMQLEERIAAFKNVEACVVFQSGFAANAGTVSAI
HHHHHHHHHHCCCCCCEEEEECEEEEEEEHHHHHHHHCCCCEEEEEECCCCCCCCCEEEE
LTPEDHIISDELNHASIIDGCRLSRAKIHVFAHKDVAAAEKILAELAPLPGRKLLITDGV
ECCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCE
FSMDGDIGPLPGLAGAAEKHGAIMMVDDAHASGVLGRNGRGTIDHFGVHGRVHVQVGTLS
EECCCCCCCCCCCCCCHHHCCEEEEEECCCCCCCCCCCCCCCHHCCCCCCEEEEEECHHH
KAIGVLGGYVCGSRDLIEFLYHRARPFLFSTSHPPAVAAACLAAFDVLEQEPERIEQLWD
HHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHC
NTRYFKKGLQEAGFNTGISETPITPVIVGEAALAHRLSRELFDEGVLATGIGFPTVAKGK
CHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCEEECCCCCCCCCCH
ARVRTIVASTHTKAELDQALEAFRKVGKKLGILQVR
HHHEEHHHCCCCHHHHHHHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA