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The map label for this gene is adhA [H]

Identifier: 116624247

GI number: 116624247

Start: 6489794

End: 6490774

Strand: Reverse

Name: adhA [H]

Synonym: Acid_5165

Alternate gene names: 116624247

Gene position: 6490774-6489794 (Counterclockwise)

Preceding gene: 116624248

Following gene: 116624245

Centisome position: 65.13

GC content: 66.16

Gene sequence:

>981_bases
ATGCGTGCAGCTATTTTGCACTCGCCCGGATCGCCGCTGGAAATTGAGCAGGTGGCGGAGCCCTCACTCGGGGCAGGGCA
GGTTCTGATCCGCGTCAAGGCGTGCGGAGTTTGCCGGACCGACCTGCATATTACGGAGGGCGATCTTCCGGCGCGGCGGA
AGCCGCTGATCCCGGGCCATCAGACCGTGGGTGAGATCGCGGGCGGCGCGACGGCGGAGTTGCCGATGGGCACCCGGGTC
GGCGTCTCGTGGATCGGCGGCGTGGATGGCACTTGCCGCTATTGCCGCGGTAACGCGGAGAACCTCTGCGATGATCCCAC
GTTCACCGGCTATACCGTGGATGGCGGCTACGCCGAGTTCGCTGCCGCGCGCGCAGATTTCGTTTTTCGCTTGCCGGAGG
CGCTCGATGATATGCAGGCCGCGCCGCTGCTTTGTGCAGGCATTATCGGTTTCCGCAGCCTGCGTGTGGCAGAGGTTGAG
GCCGGGGAGAACGTGGGACTGTTCGGCTTCGGAGCCTCGGCGCACCTGGCGATCGCGGTGCTGAAAAGCTGGGGCTGCAA
GGTGTACGTCTCGACGCGCGGCGAATCGCATCGCCGACTGGCCGGCGAATTGGGCGCTGCCTGGGTGGGCGACGAGCGCG
ATCGTCCGCCGGTGGAACTGGATCGCGCGGTGACGTTCGCACCCGCGGGCGACGTGGTGATCGCCGCGCTCGGCGCCTTG
CGCAAGGGCGGCGTGGTGGCGATTAATGCGATTCATCTCGACCGCATCCCGGAGTTCGATTACGACCGCCTGCTGTGGGG
CGAACGTCAGATCCGCAGCGTCGCTAATATGACCCGCGCGGACGCTCGCGATTTCCTGCGCATCGCCGCCGAGATCGGAC
TGCGGCCCAGAGTGACTCGATTTCCTCTTGACCAGGCGAACGCCGCGCTCAGGGCGATCAAGCGGGATGAGATCGATGGA
GCGGCGGTGATTACGCCGTGA

Upstream 100 bases:

>100_bases
CGCACACGAAGGCGGAGTTGGATCAGGCGCTGGAGGCGTTCCGCAAGGTCGGGAAGAAGCTCGGGATACTCCAAGTGCGG
TAGCGTGAAGGAAGGACGCT

Downstream 100 bases:

>100_bases
ACGGCTGATGGCCGAGGGAGCGATCTGCGTTGGCTCCGGGCAAGCGGGCTGCACGGTCGAAAGGCCTGCGAGGAGCAAGG
GAATACTTCTAAAAAAGCGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MRAAILHSPGSPLEIEQVAEPSLGAGQVLIRVKACGVCRTDLHITEGDLPARRKPLIPGHQTVGEIAGGATAELPMGTRV
GVSWIGGVDGTCRYCRGNAENLCDDPTFTGYTVDGGYAEFAAARADFVFRLPEALDDMQAAPLLCAGIIGFRSLRVAEVE
AGENVGLFGFGASAHLAIAVLKSWGCKVYVSTRGESHRRLAGELGAAWVGDERDRPPVELDRAVTFAPAGDVVIAALGAL
RKGGVVAINAIHLDRIPEFDYDRLLWGERQIRSVANMTRADARDFLRIAAEIGLRPRVTRFPLDQANAALRAIKRDEIDG
AAVITP

Sequences:

>Translated_326_residues
MRAAILHSPGSPLEIEQVAEPSLGAGQVLIRVKACGVCRTDLHITEGDLPARRKPLIPGHQTVGEIAGGATAELPMGTRV
GVSWIGGVDGTCRYCRGNAENLCDDPTFTGYTVDGGYAEFAAARADFVFRLPEALDDMQAAPLLCAGIIGFRSLRVAEVE
AGENVGLFGFGASAHLAIAVLKSWGCKVYVSTRGESHRRLAGELGAAWVGDERDRPPVELDRAVTFAPAGDVVIAALGAL
RKGGVVAINAIHLDRIPEFDYDRLLWGERQIRSVANMTRADARDFLRIAAEIGLRPRVTRFPLDQANAALRAIKRDEIDG
AAVITP
>Mature_326_residues
MRAAILHSPGSPLEIEQVAEPSLGAGQVLIRVKACGVCRTDLHITEGDLPARRKPLIPGHQTVGEIAGGATAELPMGTRV
GVSWIGGVDGTCRYCRGNAENLCDDPTFTGYTVDGGYAEFAAARADFVFRLPEALDDMQAAPLLCAGIIGFRSLRVAEVE
AGENVGLFGFGASAHLAIAVLKSWGCKVYVSTRGESHRRLAGELGAAWVGDERDRPPVELDRAVTFAPAGDVVIAALGAL
RKGGVVAINAIHLDRIPEFDYDRLLWGERQIRSVANMTRADARDFLRIAAEIGLRPRVTRFPLDQANAALRAIKRDEIDG
AAVITP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=242, Percent_Identity=28.9256198347107, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI13236495, Length=242, Percent_Identity=28.9256198347107, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI194239676, Length=219, Percent_Identity=30.1369863013699, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI156627571, Length=336, Percent_Identity=25.8928571428571, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081918, Length=335, Percent_Identity=27.4626865671642, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI87082401, Length=321, Percent_Identity=27.7258566978193, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786518, Length=226, Percent_Identity=31.4159292035398, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787863, Length=220, Percent_Identity=28.1818181818182, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790045, Length=198, Percent_Identity=30.8080808080808, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082125, Length=200, Percent_Identity=32, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788073, Length=340, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI226510992, Length=173, Percent_Identity=30.635838150289, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786825, Length=273, Percent_Identity=25.2747252747253, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=293, Percent_Identity=27.6450511945392, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562584, Length=303, Percent_Identity=29.042904290429, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=337, Percent_Identity=24.0356083086053, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=264, Percent_Identity=26.8939393939394, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=201, Percent_Identity=27.363184079602, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=208, Percent_Identity=31.7307692307692, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324486, Length=208, Percent_Identity=33.6538461538462, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323961, Length=209, Percent_Identity=33.0143540669856, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319621, Length=209, Percent_Identity=32.5358851674641, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323980, Length=187, Percent_Identity=31.0160427807487, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=312, Percent_Identity=25.9615384615385, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17137530, Length=213, Percent_Identity=27.2300469483568, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17737897, Length=247, Percent_Identity=27.9352226720648, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34785; Mature: 34785

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAILHSPGSPLEIEQVAEPSLGAGQVLIRVKACGVCRTDLHITEGDLPARRKPLIPGH
CCCEEECCCCCCCCHHHHCCCCCCCCEEEEEEEECCEEECCCEEECCCCCCCCCCCCCCC
QTVGEIAGGATAELPMGTRVGVSWIGGVDGTCRYCRGNAENLCDDPTFTGYTVDGGYAEF
HHHHHHCCCCEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHH
AAARADFVFRLPEALDDMQAAPLLCAGIIGFRSLRVAEVEAGENVGLFGFGASAHLAIAV
HHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCHHHHHHHH
LKSWGCKVYVSTRGESHRRLAGELGAAWVGDERDRPPVELDRAVTFAPAGDVVIAALGAL
HHHCCCEEEEECCCCCHHHHHHHHCCEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHH
RKGGVVAINAIHLDRIPEFDYDRLLWGERQIRSVANMTRADARDFLRIAAEIGLRPRVTR
CCCCEEEEEEEEECCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
FPLDQANAALRAIKRDEIDGAAVITP
CCCHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MRAAILHSPGSPLEIEQVAEPSLGAGQVLIRVKACGVCRTDLHITEGDLPARRKPLIPGH
CCCEEECCCCCCCCHHHHCCCCCCCCEEEEEEEECCEEECCCEEECCCCCCCCCCCCCCC
QTVGEIAGGATAELPMGTRVGVSWIGGVDGTCRYCRGNAENLCDDPTFTGYTVDGGYAEF
HHHHHHCCCCEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHH
AAARADFVFRLPEALDDMQAAPLLCAGIIGFRSLRVAEVEAGENVGLFGFGASAHLAIAV
HHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCHHHHHHHH
LKSWGCKVYVSTRGESHRRLAGELGAAWVGDERDRPPVELDRAVTFAPAGDVVIAALGAL
HHHCCCEEEEECCCCCHHHHHHHHCCEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHH
RKGGVVAINAIHLDRIPEFDYDRLLWGERQIRSVANMTRADARDFLRIAAEIGLRPRVTR
CCCCEEEEEEEEECCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
FPLDQANAALRAIKRDEIDGAAVITP
CCCHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]