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The map label for this gene is zraS [C]

Identifier: 116622277

GI number: 116622277

Start: 4014782

End: 4017310

Strand: Direct

Name: zraS [C]

Synonym: Acid_3171

Alternate gene names: 116622277

Gene position: 4014782-4017310 (Clockwise)

Preceding gene: 116622275

Following gene: 116622280

Centisome position: 40.29

GC content: 59.87

Gene sequence:

>2529_bases
ATGTTCGAAAAGCGATCGAGTTGGTGGGCGCGAACGATGGGGATCGTCGCAGCCTGTGGGATCGTTGGCATCCTGGCGTT
CCGCTACTTCGAGCCTGCGGCTCCGGCCTCTGCGCGGCATCCGCTTCGCATCGGCTTTGAGGAGAATCCCCCTGTCCAGA
TCCGCACGGCCGAAGGCTTCTCGGGACTCAGCGTCGAGACGGTGAATGAAGCGGCGAAGCGGGCCGGGATTCAGTTCGAA
TGGGTGGAAACGGGTAGGAGTTCGGAAGAGTCTTTGCGCCAAGGCCTCGTAGACCTCTGGCCGCTGGTGGTGGACCTGCC
GGACAGGCGGCAGTTCATGCATTTCGCCCGGCCGTGGATGCACAGCAGTTACGTCCTCCTGCTCCGCGAAGGAACTCAGA
TCGCCGACCGCAGCGTACCCGGCCGGATTGCGGTATTCAAGATGCCCTTACACTCGCGGCTCGCGCGCGAGCGATTTCCC
GCAGCACAGGTCGTGGAGACGGCGGCTGCCCATGGCGTCATCAGCCAGGTCTGCACGGGGGCCGCCGCCGCGGGGTTTTT
CGAAATGCGGATGGCGCAAAGCGAGTTACGGGAAAGACCCCCCGAGTGCGCGGGTGTGGTCCTCCGCCTCCATACACTCC
CGAACATGACACTGCAGGCCGGCTTGGCTTCCACCTTCGAAGCGGCCGGACAGGCAGACCGGATCCAGCGCGAAATCGCC
AATATGTTTCTGGACGGATCGCTGGCTGTGCTGATTGCCAAGTACTCGTATTTTGGCCTCGACGATACCTGGGCTTCCTA
CGAACAAATCGATGCGGAGAGGCGGCGGCTCTGGCTGATTTGGCTGGCGATCGGCGTGGCGTTCGCCGCGGGCATTGTGC
TATGGCAGGCGAGTTCCTTGCGGCAGCGCAAGCGGGCGGAATCCGCGCTTCGCGAGAGCGAGGAGCGTTTCCGCACTCTG
GCGAATACCGTACCGGTAACGATCATGGCGGCCGGCGCCGATGGCCAAGCCACATTTTTCAACAAGACGTGGCTGGACTT
TACGGGACGAAGCTTGAAAGAGGAACTTGGTTGGGGATGGGCCGAGAATCTACATCAGGACGACCGCGATCGTGCCATTA
GAGAGCACTCGGCATCTGCCGCGACACACCAGGCTTGCCGGGTCGAGTTCCGCTTGCGAAGGGCAGATGGTGAATACCGG
CATATGATGTGCACGGGCGTGCCGCACATTGAGCCCAACGGCGCCTTTGCCGGCTATATCGCCAGTTGCGTCGATCTTAC
CGATATCGAGAGCGCGCAGGATGAGGCCAGGGAGAGGCAGAATCTGGAGAGCCTGGGCGTGCTGGCCGGCGGCATCGCTC
ATGACTTCAACAACCTGCTGGGAGCAACGCTCTCCTACTCCGAACTTGGCCAGATGAAGCTCGATGAAGGGAGCACTCCG
GAAGAGGAGCTGCTGAAAATCCGCGAAGTGGCCGTACGCGGGTGCGAGATTGTCCGTCAACTCATGATTTTTTCCGGCAA
GGAGCGTGGCACGGTCGAAGCGCTGGATGTCTCCTCGCTGGTGAGCGAGATGCTCGAGCTGCTCCGGGTCTCGATCTCGA
AAAACGCGGTGCTGAAGACCAACCTGAGAAAAGGCCTGCCCGCGGTGCAAGGAAATCCGGCGCAAATCCGGCAGGTTGTC
ATGAACCTGGTAATCAACGCCTCGGAGGCGATCGGCGATCGGAATGGGGTCGTTCGAGTGGAAACCGAATGTGTCCATGT
GACACCGGACTCCAACCTGCCGGGAGCCAAAGGCAGGGAGGAAGGAAACTACTTGTTGCTGGAGGTTTCCGATAACGGAT
CCGGGATGACGAAGGATACGCAGCGAAAGGCCTTCGATCCGTTCTTCACCACCAAGTTCGCCGGCAGGGGGATGGGGCTC
GCAGTGGTCCAGCAAATCGTTCGCGGGCTCGGCGGCGACATCCAAGTGGCAAGTTCAGTAGGCAACGGAACCAGCATCAA
GATCATGCTGCCGTGTGCGACGGGGCCAATTTCAGTTAAAGAGCGCCACATAGCCGCCCGTCAACATCCCGAACTGCCGA
TACACGTGCAGACGGCGCGCACCATATTGGTGGTCGAGGATGAGGAACCGCTGCTGTTTGCCGTATCGAAACTGCTTGAG
GGCCGTGGATTCCGGGTAATTCAAGCCGGCAACGGAACCTCGGCGCTGGAGCTGATCCGGAACCGGGAGAACCACATTGA
TGCAATGCTCCTCGATTTTACTCTGCCGGGCGTATCCAGTCGCGAAGTATTGCAGGAGGTTAAGCAGGTCCAGCCGGATC
TCCTGGTGATTCTCACCAGCGCTTACAGCCGGGAAAGTGTTGCCACTTCCCTGGCCGGACTTGGGTTTGAGAGCTTCATC
AGGAAACCATTTCAGATTGAAGATCTGATGGTTTTATTGGAGGGAAGCCTATACATGCTGCCTTGCGGTTCGCCAGGCCC
GAGTGAAACGCTCATAAGTTCGCAAACGATCGATCCGTCAATGCCCTAA

Upstream 100 bases:

>100_bases
AAAATACTCCCGATCGCTCCGTGGGCTGGGGAGTGCCGGTGGACGTGATGGAGAGTATTATGGTGGACCAGGAGCATCTT
TCAGGACCGGGTTTTCCAAA

Downstream 100 bases:

>100_bases
CTCGTGCCATCCTCGTGGATGCGCTTTCAGATGTTTGCTGGCGCGACAAATTTGGACTCAGTGTGGTGACACCACGAAAC
CAGATACACTAGGCCTTCCC

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 842; Mature: 842

Protein sequence:

>842_residues
MFEKRSSWWARTMGIVAACGIVGILAFRYFEPAAPASARHPLRIGFEENPPVQIRTAEGFSGLSVETVNEAAKRAGIQFE
WVETGRSSEESLRQGLVDLWPLVVDLPDRRQFMHFARPWMHSSYVLLLREGTQIADRSVPGRIAVFKMPLHSRLARERFP
AAQVVETAAAHGVISQVCTGAAAAGFFEMRMAQSELRERPPECAGVVLRLHTLPNMTLQAGLASTFEAAGQADRIQREIA
NMFLDGSLAVLIAKYSYFGLDDTWASYEQIDAERRRLWLIWLAIGVAFAAGIVLWQASSLRQRKRAESALRESEERFRTL
ANTVPVTIMAAGADGQATFFNKTWLDFTGRSLKEELGWGWAENLHQDDRDRAIREHSASAATHQACRVEFRLRRADGEYR
HMMCTGVPHIEPNGAFAGYIASCVDLTDIESAQDEARERQNLESLGVLAGGIAHDFNNLLGATLSYSELGQMKLDEGSTP
EEELLKIREVAVRGCEIVRQLMIFSGKERGTVEALDVSSLVSEMLELLRVSISKNAVLKTNLRKGLPAVQGNPAQIRQVV
MNLVINASEAIGDRNGVVRVETECVHVTPDSNLPGAKGREEGNYLLLEVSDNGSGMTKDTQRKAFDPFFTTKFAGRGMGL
AVVQQIVRGLGGDIQVASSVGNGTSIKIMLPCATGPISVKERHIAARQHPELPIHVQTARTILVVEDEEPLLFAVSKLLE
GRGFRVIQAGNGTSALELIRNRENHIDAMLLDFTLPGVSSREVLQEVKQVQPDLLVILTSAYSRESVATSLAGLGFESFI
RKPFQIEDLMVLLEGSLYMLPCGSPGPSETLISSQTIDPSMP

Sequences:

>Translated_842_residues
MFEKRSSWWARTMGIVAACGIVGILAFRYFEPAAPASARHPLRIGFEENPPVQIRTAEGFSGLSVETVNEAAKRAGIQFE
WVETGRSSEESLRQGLVDLWPLVVDLPDRRQFMHFARPWMHSSYVLLLREGTQIADRSVPGRIAVFKMPLHSRLARERFP
AAQVVETAAAHGVISQVCTGAAAAGFFEMRMAQSELRERPPECAGVVLRLHTLPNMTLQAGLASTFEAAGQADRIQREIA
NMFLDGSLAVLIAKYSYFGLDDTWASYEQIDAERRRLWLIWLAIGVAFAAGIVLWQASSLRQRKRAESALRESEERFRTL
ANTVPVTIMAAGADGQATFFNKTWLDFTGRSLKEELGWGWAENLHQDDRDRAIREHSASAATHQACRVEFRLRRADGEYR
HMMCTGVPHIEPNGAFAGYIASCVDLTDIESAQDEARERQNLESLGVLAGGIAHDFNNLLGATLSYSELGQMKLDEGSTP
EEELLKIREVAVRGCEIVRQLMIFSGKERGTVEALDVSSLVSEMLELLRVSISKNAVLKTNLRKGLPAVQGNPAQIRQVV
MNLVINASEAIGDRNGVVRVETECVHVTPDSNLPGAKGREEGNYLLLEVSDNGSGMTKDTQRKAFDPFFTTKFAGRGMGL
AVVQQIVRGLGGDIQVASSVGNGTSIKIMLPCATGPISVKERHIAARQHPELPIHVQTARTILVVEDEEPLLFAVSKLLE
GRGFRVIQAGNGTSALELIRNRENHIDAMLLDFTLPGVSSREVLQEVKQVQPDLLVILTSAYSRESVATSLAGLGFESFI
RKPFQIEDLMVLLEGSLYMLPCGSPGPSETLISSQTIDPSMP
>Mature_842_residues
MFEKRSSWWARTMGIVAACGIVGILAFRYFEPAAPASARHPLRIGFEENPPVQIRTAEGFSGLSVETVNEAAKRAGIQFE
WVETGRSSEESLRQGLVDLWPLVVDLPDRRQFMHFARPWMHSSYVLLLREGTQIADRSVPGRIAVFKMPLHSRLARERFP
AAQVVETAAAHGVISQVCTGAAAAGFFEMRMAQSELRERPPECAGVVLRLHTLPNMTLQAGLASTFEAAGQADRIQREIA
NMFLDGSLAVLIAKYSYFGLDDTWASYEQIDAERRRLWLIWLAIGVAFAAGIVLWQASSLRQRKRAESALRESEERFRTL
ANTVPVTIMAAGADGQATFFNKTWLDFTGRSLKEELGWGWAENLHQDDRDRAIREHSASAATHQACRVEFRLRRADGEYR
HMMCTGVPHIEPNGAFAGYIASCVDLTDIESAQDEARERQNLESLGVLAGGIAHDFNNLLGATLSYSELGQMKLDEGSTP
EEELLKIREVAVRGCEIVRQLMIFSGKERGTVEALDVSSLVSEMLELLRVSISKNAVLKTNLRKGLPAVQGNPAQIRQVV
MNLVINASEAIGDRNGVVRVETECVHVTPDSNLPGAKGREEGNYLLLEVSDNGSGMTKDTQRKAFDPFFTTKFAGRGMGL
AVVQQIVRGLGGDIQVASSVGNGTSIKIMLPCATGPISVKERHIAARQHPELPIHVQTARTILVVEDEEPLLFAVSKLLE
GRGFRVIQAGNGTSALELIRNRENHIDAMLLDFTLPGVSSREVLQEVKQVQPDLLVILTSAYSRESVATSLAGLGFESFI
RKPFQIEDLMVLLEGSLYMLPCGSPGPSETLISSQTIDPSMP

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=30.7053941908714, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788549, Length=365, Percent_Identity=25.2054794520548, Blast_Score=106, Evalue=8e-24,
Organism=Escherichia coli, GI48994928, Length=535, Percent_Identity=24.2990654205607, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=288, Percent_Identity=27.4305555555556, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=765, Percent_Identity=19.7385620915033, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790300, Length=227, Percent_Identity=25.1101321585903, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI145693157, Length=132, Percent_Identity=30.3030303030303, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 92616; Mature: 92616

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKRSSWWARTMGIVAACGIVGILAFRYFEPAAPASARHPLRIGFEENPPVQIRTAEGF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCEEEEECCCC
SGLSVETVNEAAKRAGIQFEWVETGRSSEESLRQGLVDLWPLVVDLPDRRQFMHFARPWM
CCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
HSSYVLLLREGTQIADRSVPGRIAVFKMPLHSRLARERFPAAQVVETAAAHGVISQVCTG
CCCEEEEEECCCHHHCCCCCCEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AAAAGFFEMRMAQSELRERPPECAGVVLRLHTLPNMTLQAGLASTFEAAGQADRIQREIA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCHHHHHHHHHHHHCCHHHHHHHHHH
NMFLDGSLAVLIAKYSYFGLDDTWASYEQIDAERRRLWLIWLAIGVAFAAGIVLWQASSL
HHHCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQRKRAESALRESEERFRTLANTVPVTIMAAGADGQATFFNKTWLDFTGRSLKEELGWGW
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCHHHCCCCHHHHHHHCCCH
AENLHQDDRDRAIREHSASAATHQACRVEFRLRRADGEYRHMMCTGVPHIEPNGAFAGYI
HHHCCCCHHHHHHHHHCCHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCHHHHH
ASCVDLTDIESAQDEARERQNLESLGVLAGGIAHDFNNLLGATLSYSELGQMKLDEGSTP
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEECCCCCCC
EEELLKIREVAVRGCEIVRQLMIFSGKERGTVEALDVSSLVSEMLELLRVSISKNAVLKT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEC
NLRKGLPAVQGNPAQIRQVVMNLVINASEAIGDRNGVVRVETECVHVTPDSNLPGAKGRE
HHHHCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCEEEEEEEEEEECCCCCCCCCCCCC
EGNYLLLEVSDNGSGMTKDTQRKAFDPFFTTKFAGRGMGLAVVQQIVRGLGGDIQVASSV
CCCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECC
GNGTSIKIMLPCATGPISVKERHIAARQHPELPIHVQTARTILVVEDEEPLLFAVSKLLE
CCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECEEEEEEECCCCHHHHHHHHHC
GRGFRVIQAGNGTSALELIRNRENHIDAMLLDFTLPGVSSREVLQEVKQVQPDLLVILTS
CCCEEEEECCCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEC
AYSRESVATSLAGLGFESFIRKPFQIEDLMVLLEGSLYMLPCGSPGPSETLISSQTIDPS
CCCHHHHHHHHHHCCHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCHHCCCCCCCCC
MP
CC
>Mature Secondary Structure
MFEKRSSWWARTMGIVAACGIVGILAFRYFEPAAPASARHPLRIGFEENPPVQIRTAEGF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCEEEEECCCC
SGLSVETVNEAAKRAGIQFEWVETGRSSEESLRQGLVDLWPLVVDLPDRRQFMHFARPWM
CCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
HSSYVLLLREGTQIADRSVPGRIAVFKMPLHSRLARERFPAAQVVETAAAHGVISQVCTG
CCCEEEEEECCCHHHCCCCCCEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AAAAGFFEMRMAQSELRERPPECAGVVLRLHTLPNMTLQAGLASTFEAAGQADRIQREIA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCHHHHHHHHHHHHCCHHHHHHHHHH
NMFLDGSLAVLIAKYSYFGLDDTWASYEQIDAERRRLWLIWLAIGVAFAAGIVLWQASSL
HHHCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQRKRAESALRESEERFRTLANTVPVTIMAAGADGQATFFNKTWLDFTGRSLKEELGWGW
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCHHHCCCCHHHHHHHCCCH
AENLHQDDRDRAIREHSASAATHQACRVEFRLRRADGEYRHMMCTGVPHIEPNGAFAGYI
HHHCCCCHHHHHHHHHCCHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCHHHHH
ASCVDLTDIESAQDEARERQNLESLGVLAGGIAHDFNNLLGATLSYSELGQMKLDEGSTP
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEECCCCCCC
EEELLKIREVAVRGCEIVRQLMIFSGKERGTVEALDVSSLVSEMLELLRVSISKNAVLKT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEC
NLRKGLPAVQGNPAQIRQVVMNLVINASEAIGDRNGVVRVETECVHVTPDSNLPGAKGRE
HHHHCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCEEEEEEEEEEECCCCCCCCCCCCC
EGNYLLLEVSDNGSGMTKDTQRKAFDPFFTTKFAGRGMGLAVVQQIVRGLGGDIQVASSV
CCCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECC
GNGTSIKIMLPCATGPISVKERHIAARQHPELPIHVQTARTILVVEDEEPLLFAVSKLLE
CCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECEEEEEEECCCCHHHHHHHHHC
GRGFRVIQAGNGTSALELIRNRENHIDAMLLDFTLPGVSSREVLQEVKQVQPDLLVILTS
CCCEEEEECCCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEC
AYSRESVATSLAGLGFESFIRKPFQIEDLMVLLEGSLYMLPCGSPGPSETLISSQTIDPS
CCCHHHHHHHHHHCCHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCHHCCCCCCCCC
MP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA