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The map label for this gene is fabD [H]

Identifier: 116517048

GI number: 116517048

Start: 386947

End: 387867

Strand: Direct

Name: fabD [H]

Synonym: SPD_0383

Alternate gene names: 116517048

Gene position: 386947-387867 (Clockwise)

Preceding gene: 116516513

Following gene: 116515382

Centisome position: 18.91

GC content: 45.71

Gene sequence:

>921_bases
ATGACTAAAACAGCCTTTTTATTTGCTGGTCAAGGTGCCCAGTATCTAGGGATGGGACGGGATTTCTATGATCAGTATCC
GATTGTTAAAGAAACGATTGATCGAGCGAGTCAGGTGCTAGGTTATGATTTGCGTTATCTCATCGATACGGAAGAAGACA
AACTCAATCAGACCCGCTATACGCAACCAGCCATTCTAGCGACTTCGGTTGCTATCTACCGTTTATTGCAAGAAAAGGGC
TATCAGCCTGATATGGTTGCTGGTTTGTCTCTTGGAGAATACTCTGCCTTGGTGGCAAGCGGCGCCTTGGATTTTGAAGA
TGCGGTTGCCTTGGTAGCTAAGCGTGGAGCCTATATGGAAGAAGCGGCTCCTGCTGACTCTGGCAAGATGGTAGCAGTTC
TCAATACGCCAGTAGAGGTCATTGAAGAAGCCTGTCAAAAAGCTTCTGAACTTGGAGTGGTTACTCCAGCCAACTATAAC
ACACCTGCACAAATCGTCATTGCTGGAGAAGTGGTTGCAGTTGATCGAGCGGTTGAACTTTTGCAAGAAGCAGGTGCCAA
ACGCTTGATTCCTCTTAAGGTGTCAGGTCCCTTTCACACCTCTCTCCTTGAACCTGCTAGCCAGAAACTAGCTGAAACTC
TGGCTCAGGTAAGTTTTTCAGATTTTACTTGTCCCCTAGTCGGCAATACAGAAGCTGCTGTGATGCAAAAAGAGGACATT
GCTCAGCTCTTGACGCGTCAGGTCAAGGAACCCGTTCGTTTCTATGAAAGTATTGGGGTCATGCAAGAAGCAGGCATAAG
CAACTTTATCGAGATTGGACCGGGGAAAGTCTTGTCAGGTTTTGTTAAAAAAATTGATCAAACTGCTCACTTAGCTCATG
TGGAAGATCAAGCGAGTTTAGTAGCACTTTTAGAAAAATAG

Upstream 100 bases:

>100_bases
TCTAAAGAAGAAACAGCTGAAGAAATCCTAAAAGATTTGTATTACGGAGCCGCTAAGAAAATTCAAGAAGAAGCCTCTCG
CTGGACAGGAGTTGTAAGAA

Downstream 100 bases:

>100_bases
ACTAAAATAAGTAGAAGTTTTGAAAGGAAAAAAATGAAACTAGAACATAAAAATATCTTTATTACAGGTTCGAGTCGTGG
AATTGGTCTTGCCATCGCCC

Product: acyl-carrier-protein S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDLRYLIDTEEDKLNQTRYTQPAILATSVAIYRLLQEKG
YQPDMVAGLSLGEYSALVASGALDFEDAVALVAKRGAYMEEAAPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYN
TPAQIVIAGEVVAVDRAVELLQEAGAKRLIPLKVSGPFHTSLLEPASQKLAETLAQVSFSDFTCPLVGNTEAAVMQKEDI
AQLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGKVLSGFVKKIDQTAHLAHVEDQASLVALLEK

Sequences:

>Translated_306_residues
MTKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDLRYLIDTEEDKLNQTRYTQPAILATSVAIYRLLQEKG
YQPDMVAGLSLGEYSALVASGALDFEDAVALVAKRGAYMEEAAPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYN
TPAQIVIAGEVVAVDRAVELLQEAGAKRLIPLKVSGPFHTSLLEPASQKLAETLAQVSFSDFTCPLVGNTEAAVMQKEDI
AQLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGKVLSGFVKKIDQTAHLAHVEDQASLVALLEK
>Mature_305_residues
TKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDLRYLIDTEEDKLNQTRYTQPAILATSVAIYRLLQEKGY
QPDMVAGLSLGEYSALVASGALDFEDAVALVAKRGAYMEEAAPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYNT
PAQIVIAGEVVAVDRAVELLQEAGAKRLIPLKVSGPFHTSLLEPASQKLAETLAQVSFSDFTCPLVGNTEAAVMQKEDIA
QLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGKVLSGFVKKIDQTAHLAHVEDQASLVALLEK

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=315, Percent_Identity=33.968253968254, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI27477045, Length=111, Percent_Identity=39.6396396396396, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI41872631, Length=292, Percent_Identity=25.6849315068493, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787334, Length=308, Percent_Identity=45.1298701298701, Blast_Score=241, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71984332, Length=294, Percent_Identity=32.6530612244898, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=300, Percent_Identity=29.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24665753, Length=306, Percent_Identity=31.0457516339869, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 33107; Mature: 32976

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDLRYLIDTEEDKLNQTRY
CCCEEEEEECCCCHHHCCCCHHHHCCCHHHHHHHHHHHHHCCCHHEEEECCHHHHHHHCC
TQPAILATSVAIYRLLQEKGYQPDMVAGLSLGEYSALVASGALDFEDAVALVAKRGAYME
CCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCHHH
EAAPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYNTPAQIVIAGEVVAVDRAVEL
HCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECHHHHHHHHHHH
LQEAGAKRLIPLKVSGPFHTSLLEPASQKLAETLAQVSFSDFTCPLVGNTEAAVMQKEDI
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
AQLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGKVLSGFVKKIDQTAHLAHVEDQASL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VALLEK
HHHHCC
>Mature Secondary Structure 
TKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDLRYLIDTEEDKLNQTRY
CCEEEEEECCCCHHHCCCCHHHHCCCHHHHHHHHHHHHHCCCHHEEEECCHHHHHHHCC
TQPAILATSVAIYRLLQEKGYQPDMVAGLSLGEYSALVASGALDFEDAVALVAKRGAYME
CCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCHHH
EAAPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYNTPAQIVIAGEVVAVDRAVEL
HCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECHHHHHHHHHHH
LQEAGAKRLIPLKVSGPFHTSLLEPASQKLAETLAQVSFSDFTCPLVGNTEAAVMQKEDI
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
AQLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGKVLSGFVKKIDQTAHLAHVEDQASL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VALLEK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]