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The map label for this gene is fhs [H]

Identifier: 116517045

GI number: 116517045

Start: 1117398

End: 1119068

Strand: Reverse

Name: fhs [H]

Synonym: SPD_1087

Alternate gene names: 116517045

Gene position: 1119068-1117398 (Counterclockwise)

Preceding gene: 116516427

Following gene: 116516670

Centisome position: 54.69

GC content: 43.93

Gene sequence:

>1671_bases
ATGAAAACAGATATTGAAATCGCACAGAGTATTGAGTTGAAGCCAATTGTTGATGTTGTAGAGAAACTTGGTATTTCTTA
CGACGATTTGGAGTTGTACGGAAAGTACAAGGCTAAACTCAGCTTTGATAAAATTCGTGCAGTTGAGAGCAATCCAGTCG
GTAAATTGATCTTGGTTACTGCCATCAACCCAACACCTGCAGGTGAAGGAAAGTCGACGCTTACCATTGGTCTTGCGGAT
GCCTTGAACAAGATTGGCAAGAAAACCATGATTGCTATCCGCGAACCGTCTCTTGGTCCAGTCATGGGGATCAAGGGTGG
TGCTGCTGGTGGTGGGTATGCACAAGTTCTGCCAATGGAAGACATCAACCTCCACTTTACTGGAGATATGCATGCTATTA
CAACTGCCAACAATGCCCTTTCTGCCTTGATTGACAACCACTTGCACCAAGGGAATGAGCTGGGAATTGATCAACGTCGT
ATCCTCTGGAAACGCGTTGTGGACTTGAACGACCGTGCGCTCCGCCATGTGACTGTTGGTCTTGGTGGTCCTCTAAACGG
TATTCCACGTGAGGACGGTTTTGATATTACAGTTGCTTCAGAAATCATGGCAATTCTTTGCTTGGCAACGGACATCGAGG
ACTTGAAACGTCGTTTGGCGAATATCGTTATTGGTTATCGCTATGACCGTACGCCTGTTTCTGTAGGTGATTTGCAGGTT
GAGGGTGCCTTGGCTTTGATTTTGAAGGATGCTATTAAGCCAAACTTGGTTCAGACAATTTACGGTACACCTGCCTTTGT
ACACGGTGGTCCATTTGCCAATATTGCTCATGGCTGTAACTCTGTTTTGGCGACGACAACAGCCCTTCACTTGGCTGATT
ACACTGTTACTGAAGCTGGTTTTGGTGCGGACCTTGGTGCTGAGAAATTCCTTGATATCAAGACACCAAACTTGCCAACA
TCTCCAGATGCAGTTGTTATTGTCGCAACCCTTCGTGCCCTTAAGATGAATGGTGGTGTGGCTAAAGACGCTCTGACTGA
AGAAAATGTAGAGGCAGTTCGTGCAGGTTTTGCTAACTTGAAACGCCACGTTGAAAATATCCGTAAGTTCGGTATTCCAG
CAGTTGTAGCTATTAACGAATTTGTATCTGATACAGAAGCTGAAATTGCAGTCTTAAAAGAACTCTGTGCCTCAATCGAT
GTACCAGTTGAATTGGCTAGTGTCTGGGCTGATGGAGCAGAAGGTGGAGTAGCACTTGCCGAAACAGTTGTTAAGACAAT
TGCTGAAAATCCAGCTAACTATAAACGTTTGTATGATAATGACCTTTCTGTCCAAGAAAAGATTGAAAAAATTGTCACTG
AAATCTATCGTGGTAGCAAAGTGAACTTTGAGAAGAAATCTCAAACACAAATTGCTCAAATCGTTCAAAACGGTTGGGAC
AAATTGCCAATCTGTATGGCTAAAACTCAATACAGTTTCTCAGATAATCCAAATGCGCTTGGAGCACCAGAAAACTTTGA
AATTACCATTCGTGAATTGGTACCAAAATTAGGTGCAGGCTTCATCGTTGCCTTAACTGGTGATGTTATGACCATGCCAG
GTCTTCCAAAACGTCCAGCAGCTCTCAACATGGATGTTGAAAGCGATGGAACTGTACTAGGCTTGTTCTAG

Upstream 100 bases:

>100_bases
AAAACAGAGATATTTACGAACGTTTAGAGGGTTTTAGGATGTTAAAAATCTTGTTTTGTGATATAATGAATTATCATATA
AGAGGTTAGAGGAATTTTGA

Downstream 100 bases:

>100_bases
TGGATTGAAATTGACTTTAAGTGAGTTTGGAAATAATATCCAAGCTCATTTTTTCTCAGACTGCAAGCAGTTCATCAATA
AGATTTATACTCTTCGAAAA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase 2; FHS 2; FTHFS 2 [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLAD
ALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRR
ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQV
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPT
SPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASID
VPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKSQTQIAQIVQNGWD
KLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF

Sequences:

>Translated_556_residues
MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLAD
ALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRR
ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQV
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPT
SPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASID
VPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKSQTQIAQIVQNGWD
KLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF
>Mature_556_residues
MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLAD
ALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRR
ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQV
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPT
SPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASID
VPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKSQTQIAQIVQNGWD
KLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=42.0289855072464, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI36796743, Length=622, Percent_Identity=41.4790996784566, Blast_Score=417, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17568737, Length=625, Percent_Identity=41.92, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17568739, Length=625, Percent_Identity=41.92, Blast_Score=429, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=41.838351822504, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=41.0543130990415, Blast_Score=425, Evalue=1e-120,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=40.6451612903226, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=40.6451612903226, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=40.6451612903226, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=40.6451612903226, Blast_Score=439, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59630; Mature: 59630

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00721 FTHFS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVT
CCCCHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHEEEEECHHHHHCCCCCCCCEEEEEE
AINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPME
EECCCCCCCCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCEEECCCCCCCCCCEEEEEEC
DINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRRILWKRVVDLNDRALRHVTVG
CCEEEECCCEEEEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE
LGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHEEEEEEECCCCCCCCCEEE
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAG
CHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCEEECCC
FGADLGAEKFLDIKTPNLPTSPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANL
CCCCCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASIDVPVELASVWADGAEGGVALA
HHHHHHHHHHCCCCEEEHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHH
ETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKSQTQIAQIVQNGWD
HHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
KLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPA
CCCEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEEECCEEECCCCCCCCC
ALNMDVESDGTVLGLF
EEEEEECCCCCEEECC
>Mature Secondary Structure
MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVT
CCCCHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHEEEEECHHHHHCCCCCCCCEEEEEE
AINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPME
EECCCCCCCCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCEEECCCCCCCCCCEEEEEEC
DINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRRILWKRVVDLNDRALRHVTVG
CCEEEECCCEEEEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE
LGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHEEEEEEECCCCCCCCCEEE
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAG
CHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCEEECCC
FGADLGAEKFLDIKTPNLPTSPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANL
CCCCCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASIDVPVELASVWADGAEGGVALA
HHHHHHHHHHCCCCEEEHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHH
ETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKSQTQIAQIVQNGWD
HHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
KLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPA
CCCEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEEECCEEECCCCCCCCC
ALNMDVESDGTVLGLF
EEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA