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The map label for this gene is hemH

Identifier: 116517033

GI number: 116517033

Start: 909637

End: 910731

Strand: Direct

Name: hemH

Synonym: SPD_0895

Alternate gene names: 116517033

Gene position: 909637-910731 (Clockwise)

Preceding gene: 116516916

Following gene: 116515492

Centisome position: 44.46

GC content: 37.81

Gene sequence:

>1095_bases
ATGAAAAAAGCAATTTTAATGATGACCTTCGGTTCACCAGAAGAGATTACCTTTGAAGGTGTAGCTGATTTTTTCACAAA
TATTCGTCGTGGGGTGAGACCCCAAGACCACGAGATTCAGACTCTCTATGATAATTATGTACGAATTGGAGGCACGCCTC
TGCAAAAAATTACCCGTCAAGAGGTTACCTTGGTAGAAGCTAGGCTGGGGAATGAATACAGTGTCTACTTTGCTAATAAG
TTTTCCAGTCCCTTTATTCCAGATGTGATCGGTCAAATGGAAGCAGACGGAATTGAACAGTGTATTTGCTTGATTTTGGA
GCCCCATTATTCTTTCTACTCTGTCATGGGCTATGAAAAATTTTTAGAAAGCAAACAAATTCAATTTTTGGTCATTAAGG
ACTGGTATCAGGAAGAAGCGCTCTTAAACTATTGGGCAGATGAAATTGCTAAGATTTTAAAAGAAGAAGTAAAGCAAGAC
AGCTTTAAAGTCATCTTTTCAGCCCATAGTGTGCCCATTTTTGCCTTGGACTTTGGTGATCCTTATATAGACCAAATTTT
CGAAAATAGCAAGCTAGTCGCTGAAAAACTGGGCTTGAGTTCAGAACAATATACCAACACTTGGCAGAGTGAGAGTGATA
TTGGTATTCCATGGATTAAACCAGATGTTTTGGAGTATCTCAGAGAACAGACAGAACATCCAGACCATTATATTTTTGTA
CCTATTAGTTTCATCAGTGAGCATATTGAGGTCTTGTTTGACAATGATGTAGAATGTTATGACTTATGCCAGGAATTTGG
GGTAAACTACCATCGTCCACCAATGCCAAATACAGATTCTCGTTTGATTGATGCTTTGGTCAATACAGTTAGAGTCAATG
AAAATCAAGAGTTTAAGGAATTTCTCCCAGAAGAAGAGACCTTTGATGAGTTAGTTCCTTCAGACGAGACGAAAAACATT
TTAGCTGAATCTGAAGATTTACAAATGCCAGAATTTGTGAAAAAACTGATTGAGAAAAAAGGGCGGGAGAATGTTAAGAT
GCCTTATCTTATCAAAAAAATGCTTGAAAAAGCAGGCAAGTTACCCAAAGAGTAA

Upstream 100 bases:

>100_bases
AACAAAAGACAGAAGATTGAGAATGTCCCTATGTTAGCGTTTACTTATCGATGAATTAATGATAAAATAAACTTGATAAA
AACATCACAAGGAAGCAGTC

Downstream 100 bases:

>100_bases
AGAAAAAAGGATTTAGCTTTGCGCTAGATCCTTTTAATCGATTATTTTTTCTCAAGGAGAGCTTTTATTTCTTGAAGGAC
TTCCAATTCGGTTGGTTTTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQEVTLVEARLGNEYSVYFANK
FSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQD
SFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFV
PISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNI
LAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMLEKAGKLPKE

Sequences:

>Translated_364_residues
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQEVTLVEARLGNEYSVYFANK
FSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQD
SFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFV
PISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNI
LAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMLEKAGKLPKE
>Mature_364_residues
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQEVTLVEARLGNEYSVYFANK
FSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQD
SFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFV
PISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNI
LAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMLEKAGKLPKE

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=321, Percent_Identity=26.791277258567, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI60499025, Length=321, Percent_Identity=26.791277258567, Blast_Score=90, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324750, Length=274, Percent_Identity=26.6423357664234, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17864156, Length=325, Percent_Identity=27.6923076923077, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45552018, Length=172, Percent_Identity=33.7209302325581, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_STRP2 (Q04KS4)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816374.1
- ProteinModelPortal:   Q04KS4
- SMR:   Q04KS4
- STRING:   Q04KS4
- EnsemblBacteria:   EBSTRT00000019200
- GeneID:   4442347
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_0895
- eggNOG:   COG0276
- GeneTree:   EBGT00050000029308
- HOGENOM:   HBG697135
- OMA:   GNRNWHP
- ProtClustDB:   CLSK884032
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 42456; Mature: 42456

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQ
CCCEEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
EVTLVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEK
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
FLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQDSFKVIFSAHSVPIFALDFGD
HHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCEEEEEECCC
PYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFV
HHHHHHHCCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEE
PISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKE
EHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
FLPEEETFDELVPSDETKNILAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMLEKAGK
HCCCHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
LPKE
CCCC
>Mature Secondary Structure
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQ
CCCEEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
EVTLVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEK
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
FLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQDSFKVIFSAHSVPIFALDFGD
HHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCEEEEEECCC
PYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFV
HHHHHHHCCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEE
PISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKE
EHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
FLPEEETFDELVPSDETKNILAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMLEKAGK
HCCCHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
LPKE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA