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The map label for this gene is ndk

Identifier: 116516942

GI number: 116516942

Start: 1751319

End: 1751732

Strand: Reverse

Name: ndk

Synonym: SPD_1757

Alternate gene names: 116516942

Gene position: 1751732-1751319 (Counterclockwise)

Preceding gene: 116515724

Following gene: 116517204

Centisome position: 85.61

GC content: 42.03

Gene sequence:

>414_bases
ATGGAACAAACATTCTTTATCATCAAACCAGATGGTGTAAAAAGAGGGCTAGTGGGTGAAGTGTTAAAGCGCATCGAACA
ACGTGGATTTACAATCGAAAAATTGGAGTTTCGTTCACAGGTTTCAGAAGAGTTGATTGACCAGCACTATCAGGACTTGG
TTGGTCAGAGTTTTTACCCACCGATTCGTGAATTCATGACTTCAGGTCCAGTTCTTGTGGGTGTCATTTCTGGTCCCAAA
GTAATCGAAACTTGGCGGACCATGATGGGTGCAACTCGTCCAGAAGAAGCTTTACCAGGCACTATTCGAGGTGATTTTGC
AAAAGCTGCTGGAGAAAATGAGATTATCCAAAATGTTGTACATGGTTCAGATTCAGAAGAGTCAGCTAAGCGAGAAATTG
CTCTTTGGTTTTAA

Upstream 100 bases:

>100_bases
GAGAACCCGAGGGTTCTCTCATTCTCTCTTCTGAAAACTTTCTCCATTTTTCCACGAAATGTGGTAAAATAAAAGAAAGA
AGCTGACAAAGGAGACGGGT

Downstream 100 bases:

>100_bases
GAGTGGATTGGCTCAATCAATTGGTTAAAAGCTCATTTGAATAGAAAGTATAGTCAATTAGTTTAAGACATGACGCATGA
TATCAAACTTTTTAGTTTTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPK
VIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVVHGSDSEESAKREIALWF

Sequences:

>Translated_137_residues
MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPK
VIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVVHGSDSEESAKREIALWF
>Mature_137_residues
MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPK
VIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVVHGSDSEESAKREIALWF

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=49.6350364963504, Blast_Score=139, Evalue=7e-34,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=49.6350364963504, Blast_Score=139, Evalue=7e-34,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=49.6350364963504, Blast_Score=139, Evalue=7e-34,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=49.6350364963504, Blast_Score=139, Evalue=7e-34,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=49.6350364963504, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=50.3649635036496, Blast_Score=138, Evalue=1e-33,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=50.3649635036496, Blast_Score=138, Evalue=1e-33,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=50, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=47.7941176470588, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI5031951, Length=141, Percent_Identity=34.7517730496454, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI30023828, Length=141, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=32.3741007194245, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=32.3741007194245, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=27.1428571428571, Blast_Score=63, Evalue=8e-11,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=39.4160583941606, Blast_Score=104, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=47.0588235294118, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=46.3235294117647, Blast_Score=129, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=50, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI18860097, Length=140, Percent_Identity=30, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_STRP2 (Q04IK8)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_817180.1
- ProteinModelPortal:   Q04IK8
- SMR:   Q04IK8
- STRING:   Q04IK8
- EnsemblBacteria:   EBSTRT00000020398
- GeneID:   4442018
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1757
- eggNOG:   COG0105
- GeneTree:   EBGT00050000027936
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15440; Mature: 15440

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 121-121 BINDING 9-9 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 103-103 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYP
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
PIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVV
HHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHCCHHHHHHHHH
HGSDSEESAKREIALWF
CCCCCHHHHHHCCCCCC
>Mature Secondary Structure
MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYP
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
PIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVV
HHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHCCHHHHHHHHH
HGSDSEESAKREIALWF
CCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA