Click here to switch to the map view.

The map label for this gene is ezrA

Identifier: 116516893

GI number: 116516893

Start: 725377

End: 727104

Strand: Direct

Name: ezrA

Synonym: SPD_0710

Alternate gene names: 116516893

Gene position: 725377-727104 (Clockwise)

Preceding gene: 116516156

Following gene: 116515608

Centisome position: 35.45

GC content: 36.34

Gene sequence:

>1728_bases
ATGTCTAATGGACAACTAATTTATTTAATGGTTGCAATTGCAGTCATTTTAGTTCTGGCTTATGTAGTGGCAATCTTTCT
ACGTAAGCGAAACGAGGGGAGATTAGAGGCGCTAGAAGAAAGAAAAGAAGAACTATACAATCTTCCAGTAAATGATGAAG
TAGAAGCTGTAAAAAATATGCACTTGATTGGACAAAGTCAAGTGGCTTTCCGTGAATGGAATCAAAAATGGGTCGATTTA
TCTCTCAACTCTTTTGCCGATATTGAAAATAATCTCTTTGAAGCAGAAGGCTATAACCATTCATTTCGTTTTCTCAAGGC
CAGTCATCAAATTGACCAAATTGAGAGTCAAATTACTTTGATTGAAGAAGATATTGCGGCAATTCGCAATGCTTTGGCAG
ACTTAGAGAAGCAAGAATCTAAAAATAGTGGTCGTGTTCTTCATGCTTTGGATTTATTTGAGGAACTTCAGCATAGAGTT
GCTGAAAATTCAGAACAGTATGGTCAAGCCTTGGATGAAATTGAAAAACAATTAGAAAATATCCAATCTGAATTTTCACA
ATTTGTAACCTTGAATTCATCGGGTGACCCTGTGGAAGCCGCAGTGATTTTGGATAATACAGAAAATCACATTTTGGCCT
TAAGTCATATTGTGGATCGTGTTCCAGCCTTGGTTACGACGCTTTCTACAGAATTGCCAGATCAATTACAGGATTTGGAA
GCCGGTTATCGTAAACTAATTGATGCTAATTATCATTTTGTTGAAACGGATATTGAAGCGCGTTTCCACTTGCTTTATGA
AGCATTCAAGAAAAACCAAGAGAATATTCGTCAGTTGGAATTGGATAATGCCGAATATGAGAATGGACAGGCACAAGAGG
AAATCAATGCCTTGTATGATATTTTTACTCGAGAAATTGCTGCTCAGAAAGTAGTGGAAAATCTACTTGCAACTCTTCCA
ACTTACCTTCAACATATGAAAGAGAATAATACTTTATTGGGAGAAGATATTGCACGTTTGAACAAGACCTATTTACTTCC
TGAGACAGCTGCAAGCCATGTTCGTCGTATTCAGACAGAATTAGAGAGTTTTGAGGCAGCTATTGTTGAGGTAACTTCAA
ATCAAGAAGAACCAACCCAAGCTTATTCAGTTCTTGAAGAAAATCTTGAGGATTTACAAACTCAACTAAAAGATATTGAA
GATGAGCAAATTTCAGTTAGTGAGCGCCTGACACAAATTGAGAAAGATGATATTAATGCACGTCAAAAGGCCAATGTTTA
TGTCAATCGTCTCCATACTATCAAGCGATACATGGAAAAACGCAATCTGCCAGGTATTCCACAAACTTTCTTGAAGTTAT
TCTTTACGGCAAGCAATAATACCGAGGATTTAATGGTTGAGTTAGAACAAAAAATGATTAACATTGAATCTGTTACCCGA
GTTCTTGAAATTGCAACGAATGATATGGAAGCTTTAGAAACGGAAACTTATAATATTGTACAATATGCAACTTTGACAGA
GCAACTCTTGCAATATTCTAACCGCTATCGCTCATTTGATGAACGCATTCAAGAAGCATTTAACGAAGCTTTAGATATTT
TTGAAAAAGAATTTGATTATCACGCTTCATTTGACAAGATTTCTCAAGCATTGGAAGTGGCAGAGCCTGGTGTAACCAAT
CGCTTTGTTACCTCATATGAGAAAACACGTGAAACGATTCGTTTTTAA

Upstream 100 bases:

>100_bases
TAGTACACTTGATGTCTAAAAAATAGGGAGAAGTAGTTCCCTTGGTCTAAAAAATATGATATAATCGTTACGATTGTTTC
AAGTAAAAAAGGAGTTTGAT

Downstream 100 bases:

>100_bases
TAAAAGAAAAAGATTTTATTGTGTGAGGAGCAGAATCAAATCTTTTTCTATAGTTGTGGGGAGATTTACTTCATTTTCTC
CTGAGATTGAGTTTTTGCCC

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEELYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDL
SLNSFADIENNLFEAEGYNHSFRFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRV
AENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIVDRVPALVTTLSTELPDQLQDLE
AGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENIRQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLP
TYLQHMKENNTLLGEDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDLQTQLKDIE
DEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTFLKLFFTASNNTEDLMVELEQKMINIESVTR
VLEIATNDMEALETETYNIVQYATLTEQLLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTN
RFVTSYEKTRETIRF

Sequences:

>Translated_575_residues
MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEELYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDL
SLNSFADIENNLFEAEGYNHSFRFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRV
AENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIVDRVPALVTTLSTELPDQLQDLE
AGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENIRQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLP
TYLQHMKENNTLLGEDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDLQTQLKDIE
DEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTFLKLFFTASNNTEDLMVELEQKMINIESVTR
VLEIATNDMEALETETYNIVQYATLTEQLLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTN
RFVTSYEKTRETIRF
>Mature_574_residues
SNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEELYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDLS
LNSFADIENNLFEAEGYNHSFRFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRVA
ENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIVDRVPALVTTLSTELPDQLQDLEA
GYRKLIDANYHFVETDIEARFHLLYEAFKKNQENIRQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLPT
YLQHMKENNTLLGEDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDLQTQLKDIED
EQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTFLKLFFTASNNTEDLMVELEQKMINIESVTRV
LEIATNDMEALETETYNIVQYATLTEQLLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTNR
FVTSYEKTRETIRF

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site (By similarity)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EZRA_STRP2 (Q04L94)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816204.1
- STRING:   Q04L94
- EnsemblBacteria:   EBSTRT00000018927
- GeneID:   4442078
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_0710
- eggNOG:   COG4477
- GeneTree:   EBGT00050000028049
- HOGENOM:   HBG697174
- OMA:   MDIQELH
- ProtClustDB:   PRK04778
- HAMAP:   MF_00728
- InterPro:   IPR010379

Pfam domain/function: PF06160 EzrA

EC number: NA

Molecular weight: Translated: 66521; Mature: 66390

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1af97224)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEELYNLPVNDEVEAVKNM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
HLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAEGYNHSFRFLKASHQIDQIESQITL
HHHCCHHHHHHHHCCHHEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRVAENSEQYGQALDEIEKQLEN
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
IQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIVDRVPALVTTLSTELPDQLQDLE
HHHHHHHHEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
AGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENIRQLELDNAEYENGQAQEEINALYD
HHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHH
IFTREIAAQKVVENLLATLPTYLQHMKENNTLLGEDIARLNKTYLLPETAASHVRRIQTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LESFEAAIVEVTSNQEEPTQAYSVLEENLEDLQTQLKDIEDEQISVSERLTQIEKDDINA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCH
RQKANVYVNRLHTIKRYMEKRNLPGIPQTFLKLFFTASNNTEDLMVELEQKMINIESVTR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VLEIATNDMEALETETYNIVQYATLTEQLLQYSNRYRSFDERIQEAFNEALDIFEKEFDY
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HASFDKISQALEVAEPGVTNRFVTSYEKTRETIRF
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEELYNLPVNDEVEAVKNM
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
HLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAEGYNHSFRFLKASHQIDQIESQITL
HHHCCHHHHHHHHCCHHEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRVAENSEQYGQALDEIEKQLEN
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
IQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIVDRVPALVTTLSTELPDQLQDLE
HHHHHHHHEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
AGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENIRQLELDNAEYENGQAQEEINALYD
HHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHH
IFTREIAAQKVVENLLATLPTYLQHMKENNTLLGEDIARLNKTYLLPETAASHVRRIQTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LESFEAAIVEVTSNQEEPTQAYSVLEENLEDLQTQLKDIEDEQISVSERLTQIEKDDINA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCH
RQKANVYVNRLHTIKRYMEKRNLPGIPQTFLKLFFTASNNTEDLMVELEQKMINIESVTR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VLEIATNDMEALETETYNIVQYATLTEQLLQYSNRYRSFDERIQEAFNEALDIFEKEFDY
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HASFDKISQALEVAEPGVTNRFVTSYEKTRETIRF
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA