Click here to switch to the map view.

The map label for this gene is hrcA

Identifier: 116516738

GI number: 116516738

Start: 467523

End: 468557

Strand: Direct

Name: hrcA

Synonym: SPD_0458

Alternate gene names: 116516738

Gene position: 467523-468557 (Clockwise)

Preceding gene: 116515425

Following gene: 116517069

Centisome position: 22.85

GC content: 43.77

Gene sequence:

>1035_bases
ATGGTTACAGAGCGTCAGCAGGATATTTTAAATCTGATTATTGACATCTTTACCAAAACGCACGAACCTGTCGGATCAAA
AGCCTTGCAAGAGTCTATTAACTCTAGCAGTGCAACCATTCGTAATGACATGGCGGAACTAGAAAAACAAGGGTTGCTTG
AGAAGGCTCATACTTCAAGCGGTCGGATGCCAAGTGTTGCTGGTTTTCAGTACTATGTGAAACACTCACTGGATTTTGAC
CGACTGGCTGAAAATGAGGTATATGAGATTGTCAAAGCCTTTGATCAGGAATTCTTCAAATTGGAGGATATTCTGCAAGA
GGCTGCTAACTTGCTAACAGACCTGAGTGGCTGTACGGTAGTGGCACTGGATGTTGAGCCGAGCAGGCAACGTTTGACAG
CCTTTGATATCGTTGTTTTGGGGCAACATACAGCCTTGGCGGTATTTACCCTAGACGAGTCGCGAACGGTTACTAGTCAG
TTTCTGATTCCAAGGAACTTCTTGCAGGAGGATTTGCTGAAACTGAAGAGCATCATTCAGGAACGTTTCCTCGGTCACAC
CGTTTTAGATATTCACTACAAGATTCGGACGGAGATTCCGCAGATTATCCAGCGTTACTTTACAACAACGGATAATGTCA
TCGATCTCTTTGAACACATCTTTAAGGAAATGTTCAACGAAAACATTGTGATGGCGGGCAAGGTCAATCTCTTGAATTTT
GCCAATCTAGCAGCCTATCAGTTCTTTGACCAACCGCAAAAGGTGGCCTTGGAGATTCGTGAGGGGTTGCGTGAGGATCA
GATGCAAAATGTTCGTGTTGCAGACGGTCAAGAGTCCTGTTTAGCTGACCTAGCGGTGATTAGTAGTAAGTTCCTCATTC
CTTATCGGGGAGTTGGAATTCTAGCCATTATCGGTCCAGTTAATCTGGATTACCAACAGCTAATCAATCAAATCAATGTG
GTCAACCGTGTTTTGACCATGAAGTTGACAGATTTTTACCGCTACCTCAGCAGTAATCATTACGAAGTACATTAA

Upstream 100 bases:

>100_bases
TTTTTGTCTTGACATTCTCTTCTAAGGGTGTATAATAGAATCATAAGTTAGCACTTGGATGCATTGAGTGCTAATTGATC
AGACAGAGAGGAGTGATGAG

Downstream 100 bases:

>100_bases
GATTGAAATCATTAAAGGAGGCGAACATGGCCCAAGATATAAAAAATGAAGAAGTAGAAGAAGTTCAAGAAGAGGAAGTT
GTGGAAACAGCTGAAGAAAC

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDMAELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFD
RLAENEVYEIVKAFDQEFFKLEDILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQ
FLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHIFKEMFNENIVMAGKVNLLNF
ANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADGQESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQINV
VNRVLTMKLTDFYRYLSSNHYEVH

Sequences:

>Translated_344_residues
MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDMAELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFD
RLAENEVYEIVKAFDQEFFKLEDILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQ
FLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHIFKEMFNENIVMAGKVNLLNF
ANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADGQESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQINV
VNRVLTMKLTDFYRYLSSNHYEVH
>Mature_344_residues
MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDMAELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFD
RLAENEVYEIVKAFDQEFFKLEDILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQ
FLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHIFKEMFNENIVMAGKVNLLNF
ANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADGQESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQINV
VNRVLTMKLTDFYRYLSSNHYEVH

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_STRP2 (Q04LY2)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_815966.1
- ProteinModelPortal:   Q04LY2
- STRING:   Q04LY2
- EnsemblBacteria:   EBSTRT00000019658
- GeneID:   4442288
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_0458
- eggNOG:   COG1420
- GeneTree:   EBGT00050000026973
- HOGENOM:   HBG729878
- OMA:   VHYKLRT
- ProtClustDB:   PRK00082
- GO:   GO:0005622
- HAMAP:   MF_00081
- InterPro:   IPR001034
- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- SMART:   SM00420
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF03444 DUF293; PF01628 HrcA

EC number: NA

Molecular weight: Translated: 39369; Mature: 39369

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDMAELEKQGLLEKAHTSS
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
GRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLEDILQEAANLLTDLSGCTV
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQFLIPRNFLQEDLLKLKSIIQ
EEEECCCCHHHHHHHHEEEECCCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHH
ERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHIFKEMFNENIVMAGKVNLLNF
HHHCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHH
ANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADGQESCLADLAVISSKFLIPYRGVGI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEE
LAIIGPVNLDYQQLINQINVVNRVLTMKLTDFYRYLSSNHYEVH
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDMAELEKQGLLEKAHTSS
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
GRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLEDILQEAANLLTDLSGCTV
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQFLIPRNFLQEDLLKLKSIIQ
EEEECCCCHHHHHHHHEEEECCCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHH
ERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHIFKEMFNENIVMAGKVNLLNF
HHHCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHH
ANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADGQESCLADLAVISSKFLIPYRGVGI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEE
LAIIGPVNLDYQQLINQINVVNRVLTMKLTDFYRYLSSNHYEVH
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA