Click here to switch to the map view.

The map label for this gene is ung

Identifier: 116516721

GI number: 116516721

Start: 1058346

End: 1058999

Strand: Reverse

Name: ung

Synonym: SPD_1032

Alternate gene names: 116516721

Gene position: 1058999-1058346 (Counterclockwise)

Preceding gene: 116515370

Following gene: 116515668

Centisome position: 51.76

GC content: 43.73

Gene sequence:

>654_bases
ATGGAACACTCGTCTTGGCATGCTTTGATTAAGGCGCAATTACCTGAGGGTTATTTCGGGAAAATCAATCAGTTTATGGA
GCAGGTCTATTCTCAGGGGATTATTTATCCACCCAAGGAAAAGGTTTTTCAGGCTCTCTTGACAACACTGCTTGAAGAAG
TTAAGGTGGTAATTCTAGGGCAAGACCCCTATCACGGACCAGGTCAAGCGCAGGGCTTGAGTTTTTCTGTACCTGACTCT
ATCCCAGCTCCACCATCCTTGCAAAATATCTTGAAAGAATTGTCAGATGATATCGGAGTTAAGAAATCTCATGATTTGAC
AGCTTGGGCTGAGCAAGGAGTCTTGCTTCTTAATGCTTGTTTGACTGTTCCTGCTGGACAGGCCAATGGTCATGCTGGTC
AAATCTGGGAGCCTTTTACTGATGCTGTGATTCAGGTGGTCAATCATCTAGATAGACCAGTCGTTTTTGTACTCTGGGGA
GCTTATGCACGTAAGAAGAAGGCCTTAGTTACCAATCCTCATCACTTGATTATTGAATCAGCCCATCCAAGTCCTTTGTC
GGTTTATAGAGGATTTTGGGGTTCCAAGCCTTTTTCCAAGGCCAATACATTCTTAAAAGAGACAGGACAAGAGCCAATCG
ATTGGCTTAGATAA

Upstream 100 bases:

>100_bases
GTATATAGTCGATTTATTAAATCTTTAGATAAACTGTAAAAAGTGGTTTCCATAGCCACTTTTTGCTATAATAGAGGCAG
TAAAAATGAAGGAGTCGGCT

Downstream 100 bases:

>100_bases
GGAGAAAATATGCCTCAGTTAGCGACGATTTGTTACATTGATAATGGGAAAGAACTGCTCATGCTCCATCGTAATAAGAA
ACCCAATGATGTCCATGAAG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDS
IPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANTFLKETGQEPIDWLR

Sequences:

>Translated_217_residues
MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDS
IPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANTFLKETGQEPIDWLR
>Mature_217_residues
MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDS
IPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANTFLKETGQEPIDWLR

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=214, Percent_Identity=50.4672897196262, Blast_Score=211, Evalue=3e-55,
Organism=Homo sapiens, GI6224979, Length=214, Percent_Identity=50.4672897196262, Blast_Score=211, Evalue=3e-55,
Organism=Escherichia coli, GI1788934, Length=216, Percent_Identity=48.6111111111111, Blast_Score=199, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=45.3703703703704, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6323620, Length=230, Percent_Identity=41.304347826087, Blast_Score=158, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_STRP2 (Q04KE2)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816506.1
- ProteinModelPortal:   Q04KE2
- SMR:   Q04KE2
- STRING:   Q04KE2
- EnsemblBacteria:   EBSTRT00000020294
- GeneID:   4442309
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1032
- eggNOG:   COG0692
- GeneTree:   EBGT00050000028393
- HOGENOM:   HBG605450
- OMA:   MLWGNYA
- ProtClustDB:   PRK05254
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24080; Mature: 24080

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 62-62

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILG
CCCCHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEC
QDPYHGPGQAQGLSFSVPDSIPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNAC
CCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHH
LTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWGAYARKKKALVTNPHHLIIES
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCEECCCCEEEEEC
AHPSPLSVYRGFWGSKPFSKANTFLKETGQEPIDWLR
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILG
CCCCHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEC
QDPYHGPGQAQGLSFSVPDSIPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNAC
CCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHH
LTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWGAYARKKKALVTNPHHLIIES
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCEECCCCEEEEEC
AHPSPLSVYRGFWGSKPFSKANTFLKETGQEPIDWLR
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA