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The map label for this gene is saeR [H]

Identifier: 116516719

GI number: 116516719

Start: 83838

End: 84536

Strand: Direct

Name: saeR [H]

Synonym: SPD_0081

Alternate gene names: 116516719

Gene position: 83838-84536 (Clockwise)

Preceding gene: 116515436

Following gene: 116515418

Centisome position: 4.1

GC content: 41.77

Gene sequence:

>699_bases
ATGGGAAAGACAATTTTACTCGTTGACGACGAGGTAGAAATCACAGATATTCATCAGAGATACTTAATTCAGGCAGGTTA
TCAGGTCTTGGTAGCCCATGATGGACTGGAAGCGCTAGAGCTGTTCAAGAAAAAACCGATTGATTTGATTATCACAGATG
TCATGATGCCTCGGATGGATGGTTATGATTTAATCAGTGAGGTTCAATACTTATCACCAGAGCAGCCTTTCCTATTTATT
ACTGCTAAGACCAGTGAACAGGACAAGATTTACGGCCTGAGCTTGGGAGCAGATGATTTTATTGCTAAGCCTTTTAGCCC
ACGTGAGCTAGTTTTGCGTGTCCACAATATTTTGCGCCGCCTTCATCGTGGGGGCGAAACAGAGCTGATTTCCCTTGGCA
ATCTAAAAATGAATCATAGTAGTCATGAAGTTCAAATAGGAGAAGAAATGCTGGATTTAACTGTTAAATCATTTGAATTG
CTGTGGATTTTAGCTAGCAATCCAGAGCGAGTTTTCTCCAAGACAGACCTCTATGAAAAGATCTGGAAAGAAGACTACGT
GGATGACACCAATACCTTGAATGTGCATATCCATGCTCTTCGACAGGAGCTGGCAAAATATAGTAGTGACCAAACGCCCA
CTATTAAGACAGTTTGGGGGTTGGGATATAAGATAGAGAAACCGAGAGGACAAACATGA

Upstream 100 bases:

>100_bases
CAGGACTTTCTTTCAATAGCAGATTAAAATCATCGTAAAACAATAAAAATAGTGTTATACTTAAAGCAGTATAGCACTGT
TTTTATCAAAGGAGAGACAG

Downstream 100 bases:

>100_bases
AACTAAAAAGTTATATTTTGGTTGGATATATTATTTCAACCCTCTTAACCATTTTGGTTGTTTTTTGGGCTGTTCAAAAA
ATGCTGATTGCGAAAGGCGA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Staphylococcus exoprotein expression protein R [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MGKTILLVDDEVEITDIHQRYLIQAGYQVLVAHDGLEALELFKKKPIDLIITDVMMPRMDGYDLISEVQYLSPEQPFLFI
TAKTSEQDKIYGLSLGADDFIAKPFSPRELVLRVHNILRRLHRGGETELISLGNLKMNHSSHEVQIGEEMLDLTVKSFEL
LWILASNPERVFSKTDLYEKIWKEDYVDDTNTLNVHIHALRQELAKYSSDQTPTIKTVWGLGYKIEKPRGQT

Sequences:

>Translated_232_residues
MGKTILLVDDEVEITDIHQRYLIQAGYQVLVAHDGLEALELFKKKPIDLIITDVMMPRMDGYDLISEVQYLSPEQPFLFI
TAKTSEQDKIYGLSLGADDFIAKPFSPRELVLRVHNILRRLHRGGETELISLGNLKMNHSSHEVQIGEEMLDLTVKSFEL
LWILASNPERVFSKTDLYEKIWKEDYVDDTNTLNVHIHALRQELAKYSSDQTPTIKTVWGLGYKIEKPRGQT
>Mature_231_residues
GKTILLVDDEVEITDIHQRYLIQAGYQVLVAHDGLEALELFKKKPIDLIITDVMMPRMDGYDLISEVQYLSPEQPFLFIT
AKTSEQDKIYGLSLGADDFIAKPFSPRELVLRVHNILRRLHRGGETELISLGNLKMNHSSHEVQIGEEMLDLTVKSFELL
WILASNPERVFSKTDLYEKIWKEDYVDDTNTLNVHIHALRQELAKYSSDQTPTIKTVWGLGYKIEKPRGQT

Specific function: Member of the two-component regulatory system saeR/saeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs n

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=35.7142857142857, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=35.5263157894737, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=35.4260089686099, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=32.4444444444444, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=34.841628959276, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786784, Length=232, Percent_Identity=31.8965517241379, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=32.1266968325792, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=35.8407079646018, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790552, Length=177, Percent_Identity=37.8531073446328, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=29.6943231441048, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=32.1428571428571, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=31.2775330396476, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787229, Length=212, Percent_Identity=28.7735849056604, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790437, Length=101, Percent_Identity=37.6237623762376, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=26.2931034482759, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787487, Length=104, Percent_Identity=34.6153846153846, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=35.8490566037736, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788905, Length=100, Percent_Identity=34, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788550, Length=115, Percent_Identity=31.304347826087, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790299, Length=114, Percent_Identity=29.8245614035088, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=148, Percent_Identity=29.0540540540541, Blast_Score=60, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=116, Percent_Identity=34.4827586206897, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26684; Mature: 26553

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKTILLVDDEVEITDIHQRYLIQAGYQVLVAHDGLEALELFKKKPIDLIITDVMMPRMD
CCCEEEEECCCCEEHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCEEEEHHHHCCCC
GYDLISEVQYLSPEQPFLFITAKTSEQDKIYGLSLGADDFIAKPFSPRELVLRVHNILRR
CHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECCCHHHCCCCCHHHHHHHHHHHHHH
LHRGGETELISLGNLKMNHSSHEVQIGEEMLDLTVKSFELLWILASNPERVFSKTDLYEK
HHCCCCEEEEEECCEEECCCCCCEEHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHH
IWKEDYVDDTNTLNVHIHALRQELAKYSSDQTPTIKTVWGLGYKIEKPRGQT
HHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCC
>Mature Secondary Structure 
GKTILLVDDEVEITDIHQRYLIQAGYQVLVAHDGLEALELFKKKPIDLIITDVMMPRMD
CCEEEEECCCCEEHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCEEEEHHHHCCCC
GYDLISEVQYLSPEQPFLFITAKTSEQDKIYGLSLGADDFIAKPFSPRELVLRVHNILRR
CHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECCCHHHCCCCCHHHHHHHHHHHHHH
LHRGGETELISLGNLKMNHSSHEVQIGEEMLDLTVKSFELLWILASNPERVFSKTDLYEK
HHCCCCEEEEEECCEEECCCCCCEEHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHH
IWKEDYVDDTNTLNVHIHALRQELAKYSSDQTPTIKTVWGLGYKIEKPRGQT
HHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA