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The map label for this gene is ptrB [H]

Identifier: 116516607

GI number: 116516607

Start: 1207583

End: 1209523

Strand: Reverse

Name: ptrB [H]

Synonym: SPD_1178

Alternate gene names: 116516607

Gene position: 1209523-1207583 (Counterclockwise)

Preceding gene: 116515683

Following gene: 116517121

Centisome position: 59.11

GC content: 32.46

Gene sequence:

>1941_bases
GTGAATCAGAGTAATGAAATATTTTTAAATACAATACAGGAAAAAACACACTATAAGAGGTCTATCTCTTCATCATTTCA
GGAATTAAAAAAATGGAATTCTTTGATATTTAGGAGAGGGCGATATTGGTACCAATTTGATAATTGGAGTATACCCAATA
CTGGTGTAATAAAGGAATGGTATGTCGAAGATAATGACTGGATTCCTAAGGTTAGTTCTTCCAGTTTAGACAATTCAAAT
TCACTTAAAATTGTCTTTGATGTGGAAAAATATACTTTGCCAGATGATAGTATCTTACAGGATGTTAGGATTTCATCTGA
TGAGAGTTATATAGTTTTGGTTGTATCCTCACTGCGTAGCACTAATTTAATTGGAATAAAAAAATATACTATGGAAGAGT
TATTTATCATTGAAGATATTTCAGTAGAAAGTTCGTTCTATTTGGGTAAATTCGGTGTTATGTATACTTGCTCCAAAGAG
TACGGGAGGCCAAGTAAGTTATTCTATAAATCTTTTGATAGCTTTACAGAAGAGGAACTGTTTGAAGAAAACGAATGCTC
TTTTCGATTAAAAATAGTCCACATTGATAGCAATAATTGTTTTGTAAAGTCAGTAGACTTTCAGAAAGGCAGGATTTTTC
TATACAGTTTCGACCGGACGGGTTTTGTTAGACACTCTTACACAGAAACGGTAGCCCCAACACCTAGAGATATCGCTCTA
TTTAGTACAGAAAAAGCACAGTACTTTCTTGGGATCTCTTCAACTGAAGAAAAGAAAGATCAACTAATTCTAAGGGAAAC
TTCTTCGGGAGACAGAGTTTCTATTACTATACCATATCAAGATAGGGCTAGAAGAGTTCACTGTATAGGACGTTATATCC
TTTTAGACTGTTCAAACGCAGCGAATTCCGTCTTTTATCTTGCTACATTTAAAAATAATAGTTTGAGGGAGTTGAGTGTT
AATAAGATAACATTTGATGAAAAGACAACACTTTATGAAAATTCATTTTCTGATCGTGTTCTTCTGTTTTTAGAGAGGAG
AACTTTTTACGAAAAAATACTTAGTTTTGATTTAATAGAAAATACATTAAAAACTGAATTTGAAAGACCCATCATAAAAT
CGAATAATACTAAATATTTTTCTAAGGTGATTTGGACTAAAAAAGATAGTTATGATGTAAGCATACCGATTTCTTTATTT
TGGAAAAGTGAAGATACGGATGAGCTCCCAAGAAGAAAAAAATGTATTCTAAGTGTCTATGGGGCTTATGGTAAGAATGA
TAATTCTGATTTAGATGAAATTATGTTATCTATAATAGATGCAGGTTTTATTTATGCTATAGTTCATGTAAGAGGTGGAG
GCTATTTGGGTGGTGAATGGTATCGCTCAGGAAAGGCGTTAAACAAATGGAATTCTATCAGAGATTTTATTGAGGGAGTA
AATTATTTAAGGGAAAATGATGTAATTGACAGTAAGCGATTAGGTTTAATAACTTCTAGTGCAGGTGGAATAATTGCTGG
TGCGGTGTTGAACGAGGAAAAAAATTTATTGCAAAGCATTCTCTTATTTTCGCCATTTATAAATCCTTATGATACACTTC
AGAATCCAAATGATCCTCTTTCTAAGACCGAAATAGCAGAGTGGGGAGATATTAGAGACCCTGAAGTAAAGGCTTATATA
AAGTCATATTCGCCTATGCAAAATATTGAAAAGGCACGAGACTCAAATACTGTTATAGTTAATATTTTGGGTGAGAAAGA
CCCATATATTAATAATAACGAAGTGATAGAGTGGTCAAAGAAATTAAATTCTATTGGAGTTAAAAGTTTGTTGTATTTAA
ACAAAGCAGCTGGTCATGGAGGTTTTACTCCATCAGATGTTCTCTTAATGATTGATACTTTAAATTATTTCTTTGAAGAA
GTGGGAAGGAATAACTTATGA

Upstream 100 bases:

>100_bases
TTGCGGGTGTTGCAATTGGATTGGTATCAATAATGGATAATAAATTGACGATTCTTCCTCAAATATAATATTTAGATACC
ATTATTAAGGGGTCATACTT

Downstream 100 bases:

>100_bases
ATTATTTAAAATTTATAAAAAAGACTAAACTTATATTAATGGGGATTTTAATATTTCTATCTTCGTTTAATGGTGTCTTG
CTCTCAGGAATTATTGTATA

Product: prolyl oligopeptidase family protein

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MNQSNEIFLNTIQEKTHYKRSISSSFQELKKWNSLIFRRGRYWYQFDNWSIPNTGVIKEWYVEDNDWIPKVSSSSLDNSN
SLKIVFDVEKYTLPDDSILQDVRISSDESYIVLVVSSLRSTNLIGIKKYTMEELFIIEDISVESSFYLGKFGVMYTCSKE
YGRPSKLFYKSFDSFTEEELFEENECSFRLKIVHIDSNNCFVKSVDFQKGRIFLYSFDRTGFVRHSYTETVAPTPRDIAL
FSTEKAQYFLGISSTEEKKDQLILRETSSGDRVSITIPYQDRARRVHCIGRYILLDCSNAANSVFYLATFKNNSLRELSV
NKITFDEKTTLYENSFSDRVLLFLERRTFYEKILSFDLIENTLKTEFERPIIKSNNTKYFSKVIWTKKDSYDVSIPISLF
WKSEDTDELPRRKKCILSVYGAYGKNDNSDLDEIMLSIIDAGFIYAIVHVRGGGYLGGEWYRSGKALNKWNSIRDFIEGV
NYLRENDVIDSKRLGLITSSAGGIIAGAVLNEEKNLLQSILLFSPFINPYDTLQNPNDPLSKTEIAEWGDIRDPEVKAYI
KSYSPMQNIEKARDSNTVIVNILGEKDPYINNNEVIEWSKKLNSIGVKSLLYLNKAAGHGGFTPSDVLLMIDTLNYFFEE
VGRNNL

Sequences:

>Translated_646_residues
MNQSNEIFLNTIQEKTHYKRSISSSFQELKKWNSLIFRRGRYWYQFDNWSIPNTGVIKEWYVEDNDWIPKVSSSSLDNSN
SLKIVFDVEKYTLPDDSILQDVRISSDESYIVLVVSSLRSTNLIGIKKYTMEELFIIEDISVESSFYLGKFGVMYTCSKE
YGRPSKLFYKSFDSFTEEELFEENECSFRLKIVHIDSNNCFVKSVDFQKGRIFLYSFDRTGFVRHSYTETVAPTPRDIAL
FSTEKAQYFLGISSTEEKKDQLILRETSSGDRVSITIPYQDRARRVHCIGRYILLDCSNAANSVFYLATFKNNSLRELSV
NKITFDEKTTLYENSFSDRVLLFLERRTFYEKILSFDLIENTLKTEFERPIIKSNNTKYFSKVIWTKKDSYDVSIPISLF
WKSEDTDELPRRKKCILSVYGAYGKNDNSDLDEIMLSIIDAGFIYAIVHVRGGGYLGGEWYRSGKALNKWNSIRDFIEGV
NYLRENDVIDSKRLGLITSSAGGIIAGAVLNEEKNLLQSILLFSPFINPYDTLQNPNDPLSKTEIAEWGDIRDPEVKAYI
KSYSPMQNIEKARDSNTVIVNILGEKDPYINNNEVIEWSKKLNSIGVKSLLYLNKAAGHGGFTPSDVLLMIDTLNYFFEE
VGRNNL
>Mature_646_residues
MNQSNEIFLNTIQEKTHYKRSISSSFQELKKWNSLIFRRGRYWYQFDNWSIPNTGVIKEWYVEDNDWIPKVSSSSLDNSN
SLKIVFDVEKYTLPDDSILQDVRISSDESYIVLVVSSLRSTNLIGIKKYTMEELFIIEDISVESSFYLGKFGVMYTCSKE
YGRPSKLFYKSFDSFTEEELFEENECSFRLKIVHIDSNNCFVKSVDFQKGRIFLYSFDRTGFVRHSYTETVAPTPRDIAL
FSTEKAQYFLGISSTEEKKDQLILRETSSGDRVSITIPYQDRARRVHCIGRYILLDCSNAANSVFYLATFKNNSLRELSV
NKITFDEKTTLYENSFSDRVLLFLERRTFYEKILSFDLIENTLKTEFERPIIKSNNTKYFSKVIWTKKDSYDVSIPISLF
WKSEDTDELPRRKKCILSVYGAYGKNDNSDLDEIMLSIIDAGFIYAIVHVRGGGYLGGEWYRSGKALNKWNSIRDFIEGV
NYLRENDVIDSKRLGLITSSAGGIIAGAVLNEEKNLLQSILLFSPFINPYDTLQNPNDPLSKTEIAEWGDIRDPEVKAYI
KSYSPMQNIEKARDSNTVIVNILGEKDPYINNNEVIEWSKKLNSIGVKSLLYLNKAAGHGGFTPSDVLLMIDTLNYFFEE
VGRNNL

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI284172420, Length=279, Percent_Identity=29.3906810035842, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI284172413, Length=279, Percent_Identity=29.3906810035842, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI70778815, Length=279, Percent_Identity=29.3906810035842, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI108860686, Length=279, Percent_Identity=29.3906810035842, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI284172438, Length=279, Percent_Identity=29.3906810035842, Blast_Score=107, Evalue=5e-23,
Organism=Homo sapiens, GI284172431, Length=279, Percent_Identity=29.3906810035842, Blast_Score=107, Evalue=5e-23,
Organism=Homo sapiens, GI108860692, Length=247, Percent_Identity=29.5546558704453, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1788150, Length=272, Percent_Identity=30.1470588235294, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI221510989, Length=280, Percent_Identity=23.2142857142857, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583414, Length=249, Percent_Identity=23.6947791164659, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 74642; Mature: 74642

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQSNEIFLNTIQEKTHYKRSISSSFQELKKWNSLIFRRGRYWYQFDNWSIPNTGVIKEW
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEE
YVEDNDWIPKVSSSSLDNSNSLKIVFDVEKYTLPDDSILQDVRISSDESYIVLVVSSLRS
EECCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCHHHHHHHCCCCCCCEEEEEEECCCC
TNLIGIKKYTMEELFIIEDISVESSFYLGKFGVMYTCSKEYGRPSKLFYKSFDSFTEEEL
CCEEEEEHHHHCEEEEEEECCCCCCEEEECCCEEEEECHHCCCCHHHHHHHHHHHHHHHH
FEENECSFRLKIVHIDSNNCFVKSVDFQKGRIFLYSFDRTGFVRHSYTETVAPTPRDIAL
HCCCCCEEEEEEEEECCCCEEEEEECCCCCEEEEEEECCCCCEEECCCCCCCCCCCCEEE
FSTEKAQYFLGISSTEEKKDQLILRETSSGDRVSITIPYQDRARRVHCIGRYILLDCSNA
EECCCCEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCHHHCCEEEEEEEEEEEECCCC
ANSVFYLATFKNNSLRELSVNKITFDEKTTLYENSFSDRVLLFLERRTFYEKILSFDLIE
CCCEEEEEEECCCCEEEEEEEEEEECCCCEEECCCCCCEEEEEEHHHHHHHHHHHHHHHH
NTLKTEFERPIIKSNNTKYFSKVIWTKKDSYDVSIPISLFWKSEDTDELPRRKKCILSVY
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCCEEEEEEEEEECCCCCHHCCHHHHHHHHEE
GAYGKNDNSDLDEIMLSIIDAGFIYAIVHVRGGGYLGGEWYRSGKALNKWNSIRDFIEGV
CCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHHH
NYLRENDVIDSKRLGLITSSAGGIIAGAVLNEEKNLLQSILLFSPFINPYDTLQNPNDPL
HHHHHCCCCCCCCCEEEEECCCCEEEEEEECHHHHHHHHHHHHHCCCCHHHHCCCCCCCC
SKTEIAEWGDIRDPEVKAYIKSYSPMQNIEKARDSNTVIVNILGEKDPYINNNEVIEWSK
CCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEHHH
KLNSIGVKSLLYLNKAAGHGGFTPSDVLLMIDTLNYFFEEVGRNNL
HHHHCCHHHHHEEECCCCCCCCCHHHHEEHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNQSNEIFLNTIQEKTHYKRSISSSFQELKKWNSLIFRRGRYWYQFDNWSIPNTGVIKEW
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEE
YVEDNDWIPKVSSSSLDNSNSLKIVFDVEKYTLPDDSILQDVRISSDESYIVLVVSSLRS
EECCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCHHHHHHHCCCCCCCEEEEEEECCCC
TNLIGIKKYTMEELFIIEDISVESSFYLGKFGVMYTCSKEYGRPSKLFYKSFDSFTEEEL
CCEEEEEHHHHCEEEEEEECCCCCCEEEECCCEEEEECHHCCCCHHHHHHHHHHHHHHHH
FEENECSFRLKIVHIDSNNCFVKSVDFQKGRIFLYSFDRTGFVRHSYTETVAPTPRDIAL
HCCCCCEEEEEEEEECCCCEEEEEECCCCCEEEEEEECCCCCEEECCCCCCCCCCCCEEE
FSTEKAQYFLGISSTEEKKDQLILRETSSGDRVSITIPYQDRARRVHCIGRYILLDCSNA
EECCCCEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCHHHCCEEEEEEEEEEEECCCC
ANSVFYLATFKNNSLRELSVNKITFDEKTTLYENSFSDRVLLFLERRTFYEKILSFDLIE
CCCEEEEEEECCCCEEEEEEEEEEECCCCEEECCCCCCEEEEEEHHHHHHHHHHHHHHHH
NTLKTEFERPIIKSNNTKYFSKVIWTKKDSYDVSIPISLFWKSEDTDELPRRKKCILSVY
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCCEEEEEEEEEECCCCCHHCCHHHHHHHHEE
GAYGKNDNSDLDEIMLSIIDAGFIYAIVHVRGGGYLGGEWYRSGKALNKWNSIRDFIEGV
CCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHHH
NYLRENDVIDSKRLGLITSSAGGIIAGAVLNEEKNLLQSILLFSPFINPYDTLQNPNDPL
HHHHHCCCCCCCCCEEEEECCCCEEEEEEECHHHHHHHHHHHHHCCCCHHHHCCCCCCCC
SKTEIAEWGDIRDPEVKAYIKSYSPMQNIEKARDSNTVIVNILGEKDPYINNNEVIEWSK
CCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEHHH
KLNSIGVKSLLYLNKAAGHGGFTPSDVLLMIDTLNYFFEEVGRNNL
HHHHCCHHHHHEEECCCCCCCCCHHHHEEHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1769955; 9097040; 9278503 [H]