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The map label for this gene is typA [H]

Identifier: 116516567

GI number: 116516567

Start: 617285

End: 619126

Strand: Direct

Name: typA [H]

Synonym: SPD_0593

Alternate gene names: 116516567

Gene position: 617285-619126 (Clockwise)

Preceding gene: 116517051

Following gene: 116515475

Centisome position: 30.17

GC content: 43.81

Gene sequence:

>1842_bases
ATGACAAAATTAAGAGAAGATATCCGTAACATTGCGATTATCGCCCACGTTGACCACGGTAAAACAACCCTGGTTGACGA
ATTATTGAAACAATCAGAAACGCTTGATGCACGTACTGAATTGGCAGAGCGTGCTATGGACTCAAACGATATCGAAAAAG
AGCGTGGAATCACCATCCTTGCTAAAAATACTGCCGTTGCTTACAACGGAACTCGTATCAACATTATGGACACACCAGGA
CACGCGGACTTCGGTGGAGAAGTTGAGCGTATCATGAAAATGGTTGACGGTGTTGTCTTGGTCGTAGATGCCTATGAAGG
AACCATGCCACAAACTCGTTTCGTATTGAAAAAAGCCTTGGAACAAGACCTTGTCCCAATCGTGGTTGTTAACAAAATCG
ATAAGCCATCAGCTCGTCCAGCAGAAGTAGTGGATGAAGTCTTGGAACTTTTCATCGAGCTTGGTGCAGATGACGACCAG
CTTGATTTCCCAGTGGTTTATGCTTCAGCGATCAACGGAACTTCTTCATTGTCAGATGATCCAGCTGACCAAGAAGCGAC
TATGGCACCAATCTTTGACACGATTATCGACCATATCCCAGCTCCAGTAGATAACTCAGATGAGCCTTTGCAGTTCCAAG
TGTCACTTTTGGACTACAATGACTTCGTTGGACGTATCGGTATCGGTCGTGTCTTCCGTGGTACAGTTAAGGTTGGGGAC
CAAGTTACCCTTTCTAAACTTGACGGTACAACTAAAAACTTCCGTGTTACAAAACTCTTCGGTTTCTTTGGTTTGGAACG
TCGTGAAATCCAAGAAGCCAAAGCGGGTGACTTGATTGCCGTTTCAGGTATGGAAGACATCTTTGTCGGTGAAACCATCA
CTCCGACAGATGCAGTAGAAGCTCTTCCAATCCTACACATCGATGAGCCAACTCTTCAAATGACTTTCTTGGTCAACAAC
TCACCATTTGCTGGTAAAGAAGGTAAATGGGTAACTTCTCGTAAGGTGGAAGAACGCTTGCAGGCAGAATTGCAAACAGA
CGTTTCCCTTCGTGTTGACCCAACTGATTCACCAGATAAATGGACTGTTTCAGGACGTGGAGAATTGCACTTGTCAATCC
TTATCGAAACAATGCGTCGTGAGGGCTATGAACTTCAAGTATCTCGTCCAGAAGTTATCGTAAAAGAAATCGACGGTGTT
AAATGTGAACCATTTGAACGTGTACAAATCGACACTCCAGAAGAATACCAAGGGTCTGTTATCCAAAGCCTTTCTGAACG
TAAAGGTGAAATGTTGGATATGATTTCAACTGGTAATGGTCAAACTCGTTTGGTCTTCCTTGTTCCAGCGCGTGGTTTGA
TTGGATACTCAACTGAGTTCTTGTCAATGACTCGTGGTTACGGTATCATGAACCATACCTTCGACCAATACTTGCCATTG
ATTCCAGGGGAAATTGGTGGACGTCACCGTGGTGCCCTTGTTTCTATCGATGCTGGTAAGGCTACAACTTACTCAATCAT
GTCTATCGAAGAACGTGGTACGATCTTTGTCAACCCAGGTACTGAGGTTTATGAAGGAATGATCATCGGTGAAAACTCTC
GTGAAAATGACTTGACAGTTAACATCACGAAGGCAAAACAAATGACCAACGTTCGTTCAGCTACTAAGGACCAAACAGCT
GTTATCAAGACGCCTCGTATCTTGACACTTGAAGAGTCTCTTGAGTTCTTGAACGACGATGAGTACATGGAAGTAACGCC
TGAGTCTATCCGTTTGCGTAAACAAATCCTTAACAAAGCAGAGCGTGAGAAAGCTAACAAGAAGAAAAAATCAGCTGAAT
AA

Upstream 100 bases:

>100_bases
GAGTGAAAACATTTACACTTGCTTGAGTTATGTTATTTATTTGAAATTATGGTATAATCGTTCAGTTAGAAAATAAATTT
TGAATATTATAGAGGAAATC

Downstream 100 bases:

>100_bases
GAGCTAGAAAGAGAGAAAGATGGTCTATTTAGTCCTAGGAATTTTACTGCTCCTACTCTATGTATTTGCGACACCAGAAA
GCATTAAAGGGACAGTCAAT

Product: elongation factor Tu family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MTKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAERAMDSNDIEKERGITILAKNTAVAYNGTRINIMDTPG
HADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQDLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQ
LDFPVVYASAINGTSSLSDDPADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGD
QVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDAVEALPILHIDEPTLQMTFLVNN
SPFAGKEGKWVTSRKVEERLQAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIVKEIDGV
KCEPFERVQIDTPEEYQGSVIQSLSERKGEMLDMISTGNGQTRLVFLVPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPL
IPGEIGGRHRGALVSIDAGKATTYSIMSIEERGTIFVNPGTEVYEGMIIGENSRENDLTVNITKAKQMTNVRSATKDQTA
VIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAEREKANKKKKSAE

Sequences:

>Translated_613_residues
MTKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAERAMDSNDIEKERGITILAKNTAVAYNGTRINIMDTPG
HADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQDLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQ
LDFPVVYASAINGTSSLSDDPADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGD
QVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDAVEALPILHIDEPTLQMTFLVNN
SPFAGKEGKWVTSRKVEERLQAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIVKEIDGV
KCEPFERVQIDTPEEYQGSVIQSLSERKGEMLDMISTGNGQTRLVFLVPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPL
IPGEIGGRHRGALVSIDAGKATTYSIMSIEERGTIFVNPGTEVYEGMIIGENSRENDLTVNITKAKQMTNVRSATKDQTA
VIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAEREKANKKKKSAE
>Mature_612_residues
TKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAERAMDSNDIEKERGITILAKNTAVAYNGTRINIMDTPGH
ADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQDLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQL
DFPVVYASAINGTSSLSDDPADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGDQ
VTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDAVEALPILHIDEPTLQMTFLVNNS
PFAGKEGKWVTSRKVEERLQAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIVKEIDGVK
CEPFERVQIDTPEEYQGSVIQSLSERKGEMLDMISTGNGQTRLVFLVPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPLI
PGEIGGRHRGALVSIDAGKATTYSIMSIEERGTIFVNPGTEVYEGMIIGENSRENDLTVNITKAKQMTNVRSATKDQTAV
IKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAEREKANKKKKSAE

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=511, Percent_Identity=26.8101761252446, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=42.8571428571429, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=37.4149659863946, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=34.0136054421769, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI25306283, Length=168, Percent_Identity=35.7142857142857, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI25306287, Length=471, Percent_Identity=25.2653927813163, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI19923640, Length=168, Percent_Identity=35.7142857142857, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI34147630, Length=311, Percent_Identity=30.8681672025724, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI310132016, Length=117, Percent_Identity=39.3162393162393, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI310110807, Length=117, Percent_Identity=39.3162393162393, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI310123363, Length=117, Percent_Identity=39.3162393162393, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=38.2352941176471, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=38.2352941176471, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=32.5581395348837, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI53729339, Length=179, Percent_Identity=34.0782122905028, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI53729337, Length=179, Percent_Identity=34.0782122905028, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI48994988, Length=605, Percent_Identity=55.8677685950413, Blast_Score=700, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=509, Percent_Identity=28.8801571709234, Blast_Score=155, Evalue=9e-39,
Organism=Escherichia coli, GI1789738, Length=148, Percent_Identity=39.8648648648649, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1790835, Length=178, Percent_Identity=29.7752808988764, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790412, Length=282, Percent_Identity=32.2695035460993, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789737, Length=281, Percent_Identity=31.6725978647687, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789559, Length=172, Percent_Identity=33.1395348837209, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17557151, Length=516, Percent_Identity=27.3255813953488, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17556745, Length=446, Percent_Identity=26.0089686098655, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17533571, Length=183, Percent_Identity=38.2513661202186, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71988811, Length=134, Percent_Identity=37.3134328358209, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=134, Percent_Identity=37.3134328358209, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=161, Percent_Identity=33.5403726708075, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=37.3134328358209, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17556456, Length=312, Percent_Identity=29.4871794871795, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994658, Length=153, Percent_Identity=36.6013071895425, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25141371, Length=279, Percent_Identity=27.2401433691756, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=511, Percent_Identity=29.5499021526419, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324707, Length=147, Percent_Identity=38.7755102040816, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=147, Percent_Identity=38.7755102040816, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324761, Length=273, Percent_Identity=32.2344322344322, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323098, Length=149, Percent_Identity=35.5704697986577, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=38.0281690140845, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322359, Length=155, Percent_Identity=34.1935483870968, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI78706572, Length=516, Percent_Identity=26.1627906976744, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574573, Length=144, Percent_Identity=38.8888888888889, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24582462, Length=147, Percent_Identity=38.0952380952381, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI281363316, Length=305, Percent_Identity=31.8032786885246, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17864358, Length=305, Percent_Identity=31.8032786885246, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI21357743, Length=188, Percent_Identity=35.1063829787234, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585711, Length=153, Percent_Identity=34.640522875817, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24585713, Length=153, Percent_Identity=34.640522875817, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24585709, Length=153, Percent_Identity=34.640522875817, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221458488, Length=133, Percent_Identity=42.1052631578947, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28572034, Length=166, Percent_Identity=36.144578313253, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921738, Length=276, Percent_Identity=27.536231884058, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19922690, Length=286, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17137380, Length=270, Percent_Identity=27.4074074074074, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 68184; Mature: 68053

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAERAMDSNDIEKERGITIL
CCHHHHHHCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCEEEE
AKNTAVAYNGTRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKAL
EECEEEEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHH
EQDLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQLDFPVVYASAINGTSSLSDD
HHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCC
PADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGD
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCHHHCCCCCCHHEECEEECCC
QVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDAVE
EEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHCCCCCEEEECCCCCEEECCCCCCCHHHH
ALPILHIDEPTLQMTFLVNNSPFAGKEGKWVTSRKVEERLQAELQTDVSLRVDPTDSPDK
HCEEEEECCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHCCCEEEEECCCCCCCE
WTVSGRGELHLSILIETMRREGYELQVSRPEVIVKEIDGVKCEPFERVQIDTPEEYQGSV
EEECCCCCEEHHHHHHHHHCCCCEEEECCCHHHHHHCCCCCCCCCCEEECCCCHHHHHHH
IQSLSERKGEMLDMISTGNGQTRLVFLVPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPL
HHHHHHHCCCEEEHEECCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCHHCCHHHHCCC
IPGEIGGRHRGALVSIDAGKATTYSIMSIEERGTIFVNPGTEVYEGMIIGENSRENDLTV
CCCCCCCCCCCEEEEEECCCCEEEEEEEEECCCEEEECCCHHHHCCEEEECCCCCCCEEE
NITKAKQMTNVRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKA
EEECHHHHHHHHHCCCCCEEEEECCEEEEHHHHHHHHCCCCEEEECHHHHHHHHHHHHHH
EREKANKKKKSAE
HHHHHHHHHCCCC
>Mature Secondary Structure 
TKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAERAMDSNDIEKERGITIL
CHHHHHHCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCEEEE
AKNTAVAYNGTRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKAL
EECEEEEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHH
EQDLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQLDFPVVYASAINGTSSLSDD
HHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCC
PADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGD
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCHHHCCCCCCHHEECEEECCC
QVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDAVE
EEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHCCCCCEEEECCCCCEEECCCCCCCHHHH
ALPILHIDEPTLQMTFLVNNSPFAGKEGKWVTSRKVEERLQAELQTDVSLRVDPTDSPDK
HCEEEEECCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHCCCEEEEECCCCCCCE
WTVSGRGELHLSILIETMRREGYELQVSRPEVIVKEIDGVKCEPFERVQIDTPEEYQGSV
EEECCCCCEEHHHHHHHHHCCCCEEEECCCHHHHHHCCCCCCCCCCEEECCCCHHHHHHH
IQSLSERKGEMLDMISTGNGQTRLVFLVPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPL
HHHHHHHCCCEEEHEECCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCHHCCHHHHCCC
IPGEIGGRHRGALVSIDAGKATTYSIMSIEERGTIFVNPGTEVYEGMIIGENSRENDLTV
CCCCCCCCCCCEEEEEECCCCEEEEEEEEECCCEEEECCCHHHHCCEEEECCCCCCCEEE
NITKAKQMTNVRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKA
EEECHHHHHHHHHCCCCCEEEEECCEEEEHHHHHHHHCCCCEEEECHHHHHHHHHHHHHH
EREKANKKKKSAE
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]