Click here to switch to the map view.

The map label for this gene is gap [H]

Identifier: 116516442

GI number: 116516442

Start: 1807486

End: 1808493

Strand: Reverse

Name: gap [H]

Synonym: SPD_1823

Alternate gene names: 116516442

Gene position: 1808493-1807486 (Counterclockwise)

Preceding gene: 116515615

Following gene: 116515999

Centisome position: 88.39

GC content: 42.36

Gene sequence:

>1008_bases
ATGGTAGTTAAAGTTGGTATTAACGGTTTCGGACGTATCGGTCGTCTTGCTTTCCGTCGTATCCAAAACGTAGAAGGTGT
TGAAGTTACACGCATCAACGACCTTACAGATCCAGTTATGCTTGCACACTTGTTGAAATACGACACAACTCAAGGTCGTT
TCGACGGTACTGTTGAAGTTAAAGAAGGTGGATTTGAAGTTAACGGTAAATTCATCAAAGTTTCTGCTGAACGTGATCCA
GAACAAATCGACTGGGCTACTGACGGTGTAGAAATCGTTCTTGAAGCTACTGGTTTCTTTGCTAAGAAAGAAGCAGCTGA
AAAACACCTTAAAGGTGGAGCTAAAAAAGTTGTTATCACTGCTCCTGGTGGAAACGACGTTAAAACAGTTGTATTCAACA
CTAACCACGACGTTCTTGACGGTACTGAAACAGTTATCTCAGGTGCTTCATGTACTACAAACTGCTTGGCTCCAATGGCT
AAAGCTCTTCAAGACAACTTTGGTGTTGTTGAAGGATTGATGACTACTATCCACGCTTACACTGGTGACCAAATGATCCT
TGACGGACCACACCGTGGTGGTGACCTTCGCCGTGCTCGCGCTGGTGCTGCAAACATCGTTCCTAACTCAACTGGTGCTG
CAAAAGCTATCGGTCTTGTAATCCCAGAATTGAATGGTAAACTTGATGGATCTGCACAACGCGTTCCAACTCCAACTGGA
TCAGTTACTGAATTGGTAGCAGTTCTTGAAAAGAACGTTACTGTTGATGAAGTGAACGCAGCTATGAAAGCAGCTTCAAA
CGAATCATACGGTTACACAGAAGATCCAATCGTATCTTCAGATATCGTAGGTATGTCTTACGGTTCATTGTTTGACGCAA
CTCAAACTAAAGTTCTTGACGTTGACGGTAAACAATTGGTTAAAGTTGTATCATGGTACGACAACGAAATGTCATACACT
GCACAACTTGTTCGTACTCTTGAATACTTCGCAAAGATTGCTAAATAA

Upstream 100 bases:

>100_bases
AATAGTTGTATAATAGGTTTGTTGAAAGGTGATTTGTAGTGATTCAAGTTACTCTTTTCACAATAAAAATTTCATGATTT
TCATAAGGAGGAAATCACTA

Downstream 100 bases:

>100_bases
TTCTTGAGTTGATAGAAAGCAAGGCTTTGTGGTCTTGCTTTTTTATATGGAAAAATGGATGACACGATCATCCATTCTTT
TTTAATTCTTTTTCAAATGT

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH; Plasmin receptor; Plasminogen-binding protein [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGKFIKVSAERDP
EQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMA
KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTG
SVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYT
AQLVRTLEYFAKIAK

Sequences:

>Translated_335_residues
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGKFIKVSAERDP
EQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMA
KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTG
SVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYT
AQLVRTLEYFAKIAK
>Mature_335_residues
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGKFIKVSAERDP
EQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMA
KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTG
SVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYT
AQLVRTLEYFAKIAK

Specific function: Also binds human plasminogen [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=334, Percent_Identity=47.0059880239521, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI7657116, Length=331, Percent_Identity=43.8066465256798, Blast_Score=273, Evalue=2e-73,
Organism=Escherichia coli, GI1788079, Length=337, Percent_Identity=51.0385756676558, Blast_Score=329, Evalue=1e-91,
Organism=Escherichia coli, GI1789295, Length=342, Percent_Identity=37.719298245614, Blast_Score=231, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI32566163, Length=339, Percent_Identity=47.4926253687316, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17568413, Length=339, Percent_Identity=47.4926253687316, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17534677, Length=339, Percent_Identity=46.9026548672566, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17534679, Length=339, Percent_Identity=46.9026548672566, Blast_Score=277, Evalue=6e-75,
Organism=Saccharomyces cerevisiae, GI6322409, Length=337, Percent_Identity=44.213649851632, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6321631, Length=340, Percent_Identity=45.2941176470588, Blast_Score=276, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6322468, Length=337, Percent_Identity=45.1038575667656, Blast_Score=272, Evalue=5e-74,
Organism=Drosophila melanogaster, GI17933600, Length=332, Percent_Identity=46.9879518072289, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI18110149, Length=332, Percent_Identity=46.9879518072289, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI85725000, Length=331, Percent_Identity=47.4320241691843, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI22023983, Length=331, Percent_Identity=47.4320241691843, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI19922412, Length=330, Percent_Identity=44.8484848484849, Blast_Score=275, Evalue=4e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 35856; Mature: 35856

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEV
CEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEEE
KEGGFEVNGKFIKVSAERDPEQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVIT
ECCCEEECCEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEE
APGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMAKALQDNFGVVEGLMTTIHAY
CCCCCCEEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHC
TGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTG
CCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCCCC
SVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLD
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEE
VDGKQLVKVVSWYDNEMSYTAQLVRTLEYFAKIAK
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEV
CEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEEE
KEGGFEVNGKFIKVSAERDPEQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVIT
ECCCEEECCEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEE
APGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMAKALQDNFGVVEGLMTTIHAY
CCCCCCEEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHC
TGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTG
CCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCCCC
SVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLD
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEE
VDGKQLVKVVSWYDNEMSYTAQLVRTLEYFAKIAK
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8706717 [H]