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The map label for this gene is hom [H]

Identifier: 116516244

GI number: 116516244

Start: 1223247

End: 1224533

Strand: Reverse

Name: hom [H]

Synonym: SPD_1195

Alternate gene names: 116516244

Gene position: 1224533-1223247 (Counterclockwise)

Preceding gene: 116515689

Following gene: 116517101

Centisome position: 59.85

GC content: 42.89

Gene sequence:

>1287_bases
ATGACAGTTAAAATTGCTTTACTAGGATTTGGTACCGTTGCAAGTGGTGTGCCTTTCCTCCTAAAGGAAAATGGAGGAAA
AATCAATCAATCAGCACATTCAGATATCAAAGTTGCTAAGGTATTGGTCAAGGATGAAGATGAAAAAAATCGCTTGCTTG
CAGCAGGGAATGACTTTAACTTTGTAACCAATGTGGATGATATTTTATCAGACCAGGATATTACTATCGTAGTGGAATTG
ATGGGGCGTATTGAGCCTGCTAAAACCTTTATCACTCGTGCCTTGGAAGCTGGAAAACACGTTGTTACTGCTAACAAGGA
CCTTTTAGCTGTCCATGGCGCAGAATTGCTAGAAATCGCTCAAGCTAACAAGGTAGCACTTTACTACGAAGCAGCAGTTG
CTGGTGGGATTCCAATTCTTCGTACTTTAGCAAATTCCTTGGCTTCTGATAAAATTACGCGCGTGCTTGGAGTAGTCAAC
GGAACTTCCAACTTCATGGTGACCAAGATGGTGGAAGAAGGCTGGTCTTACGATGATGCTCTTGCGGAAGCACAACGTCT
AGGATTTGCAGAAAGCGATCCGACGAATGACGTAGATGGGATTGATGCAGCCTACAAGATGGTTATTTTGAGCCAATTTG
CCTTTGGCATGAAGATTGCCTTTGATGATGTAGCCCACAAGGGAATCCGCAATATCACACCAGAAGACGTAGCTGTAGCT
CAAGAGCTTGGTTACGTAGTGAAATTGGTTGGTTCTATTGAGGAAACTTCTTCAGGTATTGCTGCAGAAGTGACTCCAAC
CTTCCTACCTAAAGCGCACCCACTTGCTAGTGTGAATGGCGTAATGAACGCTGTCTTTGTAGAATCTATCGGTATTGGTG
AGTCTATGTACTACGGACCAGGTGCGGGTCAAAAACCAACTGCAACAAGTGTTGTAGCTGATATTGTCCGTATCGTTCGT
CGTTTGAATGATGGTACTATCGGCAAAGACTTCAACGAATATAGCCGTGACTTGGTCTTGGCAAATCCTGAAGATGTCAA
AGCAAACTACTATTTCTCAATCTTGGCTCTAGACTCAAAAGGTCAGGTCTTGAAGTTGGCTGAAATCTTCAATGCTCAAG
ATATTTCCTTTAAGCAAATCCTTCAAGATGGCAAAGAGGGTGACAAGGCGCGTGTCGTTATCATCACACACAAGATTAAT
AAAGCCCAGCTTGAAAATGTCTCAGCTGAATTGAAGAAGGTTTCAGAATTCGACCTCTTGAATACCTTCAAGGTGCTAGG
AGAATAA

Upstream 100 bases:

>100_bases
TCGTTTTTTCTTTTTATACTGAAATAGTGATTTACTATAATAGGAATTTTCACAAAATTCTGTTATAATGGCTATATTAG
AAAATTTCGAGGAGATAAAG

Downstream 100 bases:

>100_bases
GATGAAGATTATTGTACCTGCAACCAGTGCCAATATCGGGCCAGGTTTTGACTCGGTCGGTGTAGCTGTAACCAAGTATC
TTCAAATTGAGGTCTGCGAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVKDEDEKNRLLAAGNDFNFVTNVDDILSDQDITIVVEL
MGRIEPAKTFITRALEAGKHVVTANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVN
GTSNFMVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMKIAFDDVAHKGIRNITPEDVAVA
QELGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLASVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVR
RLNDGTIGKDFNEYSRDLVLANPEDVKANYYFSILALDSKGQVLKLAEIFNAQDISFKQILQDGKEGDKARVVIITHKIN
KAQLENVSAELKKVSEFDLLNTFKVLGE

Sequences:

>Translated_428_residues
MTVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVKDEDEKNRLLAAGNDFNFVTNVDDILSDQDITIVVEL
MGRIEPAKTFITRALEAGKHVVTANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVN
GTSNFMVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMKIAFDDVAHKGIRNITPEDVAVA
QELGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLASVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVR
RLNDGTIGKDFNEYSRDLVLANPEDVKANYYFSILALDSKGQVLKLAEIFNAQDISFKQILQDGKEGDKARVVIITHKIN
KAQLENVSAELKKVSEFDLLNTFKVLGE
>Mature_427_residues
TVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVKDEDEKNRLLAAGNDFNFVTNVDDILSDQDITIVVELM
GRIEPAKTFITRALEAGKHVVTANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVNG
TSNFMVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMKIAFDDVAHKGIRNITPEDVAVAQ
ELGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLASVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVRR
LNDGTIGKDFNEYSRDLVLANPEDVKANYYFSILALDSKGQVLKLAEIFNAQDISFKQILQDGKEGDKARVVIITHKINK
AQLENVSAELKKVSEFDLLNTFKVLGE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=258, Percent_Identity=27.1317829457364, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46120; Mature: 45989

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVKDEDEKNRLLAAGNDFN
CEEEEEEEECCHHHCCCCEEEECCCCCCCCCCCCCHHEEHEEECCCCCCCCEEEECCCCC
FVTNVDDILSDQDITIVVELMGRIEPAKTFITRALEAGKHVVTANKDLLAVHGAELLEIA
EEECHHHHHCCCCCEEHEEHHHCCCHHHHHHHHHHHCCCEEEECCCCEEEECCHHHHHHH
QANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVNGTSNFMVTKMVEEGWSYDDA
CCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCHHHH
LAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMKIAFDDVAHKGIRNITPEDVAVA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHCCCCHHHHHHH
QELGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLASVNGVMNAVFVESIGIGESMYYGP
HHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECC
GAGQKPTATSVVADIVRIVRRLNDGTIGKDFNEYSRDLVLANPEDVKANYYFSILALDSK
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEECCCCCCCEEEEEEEEECCC
GQVLKLAEIFNAQDISFKQILQDGKEGDKARVVIITHKINKAQLENVSAELKKVSEFDLL
CCEEEHHHHHCCCCCCHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
NTFKVLGE
HHHHHHCC
>Mature Secondary Structure 
TVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVKDEDEKNRLLAAGNDFN
EEEEEEEECCHHHCCCCEEEECCCCCCCCCCCCCHHEEHEEECCCCCCCCEEEECCCCC
FVTNVDDILSDQDITIVVELMGRIEPAKTFITRALEAGKHVVTANKDLLAVHGAELLEIA
EEECHHHHHCCCCCEEHEEHHHCCCHHHHHHHHHHHCCCEEEECCCCEEEECCHHHHHHH
QANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVNGTSNFMVTKMVEEGWSYDDA
CCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCHHHH
LAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMKIAFDDVAHKGIRNITPEDVAVA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHCCCCHHHHHHH
QELGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLASVNGVMNAVFVESIGIGESMYYGP
HHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECC
GAGQKPTATSVVADIVRIVRRLNDGTIGKDFNEYSRDLVLANPEDVKANYYFSILALDSK
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEECCCCCCCEEEEEEEEECCC
GQVLKLAEIFNAQDISFKQILQDGKEGDKARVVIITHKINKAQLENVSAELKKVSEFDLL
CCEEEHHHHHCCCCCCHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
NTFKVLGE
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]