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The map label for this gene is fruA [H]

Identifier: 116516221

GI number: 116516221

Start: 783562

End: 785514

Strand: Direct

Name: fruA [H]

Synonym: SPD_0773

Alternate gene names: 116516221

Gene position: 783562-785514 (Clockwise)

Preceding gene: 116516872

Following gene: 116517016

Centisome position: 38.3

GC content: 44.6

Gene sequence:

>1953_bases
ATGAAAATTCAAGACCTATTGAGAAAAGATGTCATGTTGCTAGATTTGCAGGCAACTGAAAAAACAGCTGTCATCGACGA
GATGATTAAAAATTTGACAGAGCACGGTTATGTAACAGATTTTGAAACATTTAAAGAAGGAATTTTGGCGCGTGAAGCTT
TGACTTCTACTGGTTTGGGTGATGGAATCGCAATGCCTCACAGCAAAAACGCTGCTGTCAAAGAAGCGACAGTTCTATTT
GCTAAGTCAAATAAGGGTGTTGACTACGAGAGCTTGGATGGACAAGCAACTGACCTCTTCTTCATGATTGCAGCTCCAGA
AGGTGCCAATGATACTCACTTGGCAGCCTTGGCAGAATTGTCTCAATACTTGATGAAAGACGGTTTTGCAGACAAACTTC
GTCAAGCAACATCTGCAGACCAAGTTATCGAACTTTTTGACCAAGCTTCAGAAAAAACTGAGGAACTTGTTCAAGCACCT
GCTAATGACTCTGGTGACTTTATCGTAGCTGTTACAGCTTGTACAACAGGTATTGCCCACACTTACATGGCCCAAGAAGC
CCTTCAAAAAGTAGCTGCTGAAATGGGGGTTGGTATCAAGGTCGAAACCAACGGTGCTAGCGGTGTTGGAAATCAACTAA
CTGCAGAAGATATCCGTAAGGCTAAAGCTATTATCATTGCAGCAGACAAGGCCGTTGAAATGGATCGATTTGATGGAAAA
CCATTGATCAATCGTCCAGTTGCTGACGGTATCCGTAAGACAGAAGAGCTAATTAACTTGGCTCTTTCAGGAGATACTGA
AGTCTACCGTGCCGCTAATGGTGCCAAAGCTGCAACAGCCTCTAACGAAAAACAAAGCCTTGGTGGTGCCTTGTACAAAC
ACTTGATGAGTGGTGTATCTCAAATGTTACCATTCGTTATCGGTGGTGGTATCATGATTGCCCTTGCCTTCTTGATTGAC
GGTGCTTTGGGTGTTCCAAATGAAAACCTTGGCAATCTTGGTTCTTACCATGAGTTAGCTTCTATGTTCATGAAAATTGG
TGGAGCTGCCTTTGGTTTGATGCTTCCAGTCTTTGCGGGTTATGTTGCCTACTCTATTGCTGAAAAACCGGGTTTGGTAG
CAGGTTTCGTGGCTGGTGCTATTGCCAAAGAAGGTTTTGCCTTTGGTAAAATTCCTTATGCCGCAGGTGGTGAAGCAACT
TCAACTCTTGCAGGTGTCTCATCTGGTTTCCTAGGTGCCCTTGTTGGTGGATTTATCGCAGGTGCCTTGGTTCTTGCCAT
CAAGAAATACGTTAAAGTTCCTCGTTCACTCGAAGGTGCTAAATCAATCCTTCTATTGCCACTTCTTGGAACAATCTTGA
CAGGATTTGTTATGCTAGCTGTGAATATCCCAATGGCTGCAATCAACACTGCTATGAATGACTTCCTAGGCGGTCTTGGA
GGAGGTTCAGCTGTCCTTCTTGGTATCGTCCTTGGTGGAATGATGGCTGTTGACATGGGTGGACCAGTTAATAAAGCAGC
TTGTGTCTTTGGTACAGGTACGCTTGCAGCAACTGTTTCTTCAGGTGGTTCTGTAGCCATGGCAGCAGTTATGGCTGGAG
GAATGGTGCCACCACTTGCAATCTTTGTCGCAACTCTTCTTTTCAAAGATAAATTTACTAAGGAAGAACGTAACTCTGGT
TTGACAAACATCATCATGGGCTTGTCATTTATCACTGAGGGAGCGATTCCATTTGGTGCCGCTGACCCAGCTCGTGCGAT
TCCAAGCTTCATCCTTGGTTCAGCAGTAGCAGGTGGACTCGTTGGTCTTACTGGTATCAAACTCATGGCGCCACACGGAG
GAATCTTCGTTATCGCCCTTACTTCAAATGCTCTCCTTTACCTCGTTTCTGTCTTGGTAGGAGCAATCGTAAGTGGTGTG
GTTTATGGTTACCTACGCAAACCACAAGCATAA

Upstream 100 bases:

>100_bases
AATGGGGAGTGGCTTGCGGAACGGCAACTACCTTCTCAGATGACTTGGCAACGGCGGAATTTATTAAAGAAACATATGGA
AAAGTTGAGGTAGAAAAAAG

Downstream 100 bases:

>100_bases
AAAATAGAAAAATGAAAAGATTGGACCGTTTGGTGCAGTCTTTTTCTCTTCCCGAAATGCCTGTGAAATATGGTATAATA
GAAGAATGGCAAACAAGAAT

Product: PTS system, fructose specific IIABC components

Products: NA

Alternate protein names: EIIABC-Fru; Fructose-specific phosphotransferase enzyme IIA component; EII-Fru; PTS system fructose-specific EIIA component; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTEHGYVTDFETFKEGILAREALTSTGLGDGIAMPHSKNAAVKEATVLF
AKSNKGVDYESLDGQATDLFFMIAAPEGANDTHLAALAELSQYLMKDGFADKLRQATSADQVIELFDQASEKTEELVQAP
ANDSGDFIVAVTACTTGIAHTYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDIRKAKAIIIAADKAVEMDRFDGK
PLINRPVADGIRKTEELINLALSGDTEVYRAANGAKAATASNEKQSLGGALYKHLMSGVSQMLPFVIGGGIMIALAFLID
GALGVPNENLGNLGSYHELASMFMKIGGAAFGLMLPVFAGYVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIPYAAGGEAT
STLAGVSSGFLGALVGGFIAGALVLAIKKYVKVPRSLEGAKSILLLPLLGTILTGFVMLAVNIPMAAINTAMNDFLGGLG
GGSAVLLGIVLGGMMAVDMGGPVNKAACVFGTGTLAATVSSGGSVAMAAVMAGGMVPPLAIFVATLLFKDKFTKEERNSG
LTNIIMGLSFITEGAIPFGAADPARAIPSFILGSAVAGGLVGLTGIKLMAPHGGIFVIALTSNALLYLVSVLVGAIVSGV
VYGYLRKPQA

Sequences:

>Translated_650_residues
MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTEHGYVTDFETFKEGILAREALTSTGLGDGIAMPHSKNAAVKEATVLF
AKSNKGVDYESLDGQATDLFFMIAAPEGANDTHLAALAELSQYLMKDGFADKLRQATSADQVIELFDQASEKTEELVQAP
ANDSGDFIVAVTACTTGIAHTYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDIRKAKAIIIAADKAVEMDRFDGK
PLINRPVADGIRKTEELINLALSGDTEVYRAANGAKAATASNEKQSLGGALYKHLMSGVSQMLPFVIGGGIMIALAFLID
GALGVPNENLGNLGSYHELASMFMKIGGAAFGLMLPVFAGYVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIPYAAGGEAT
STLAGVSSGFLGALVGGFIAGALVLAIKKYVKVPRSLEGAKSILLLPLLGTILTGFVMLAVNIPMAAINTAMNDFLGGLG
GGSAVLLGIVLGGMMAVDMGGPVNKAACVFGTGTLAATVSSGGSVAMAAVMAGGMVPPLAIFVATLLFKDKFTKEERNSG
LTNIIMGLSFITEGAIPFGAADPARAIPSFILGSAVAGGLVGLTGIKLMAPHGGIFVIALTSNALLYLVSVLVGAIVSGV
VYGYLRKPQA
>Mature_650_residues
MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTEHGYVTDFETFKEGILAREALTSTGLGDGIAMPHSKNAAVKEATVLF
AKSNKGVDYESLDGQATDLFFMIAAPEGANDTHLAALAELSQYLMKDGFADKLRQATSADQVIELFDQASEKTEELVQAP
ANDSGDFIVAVTACTTGIAHTYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDIRKAKAIIIAADKAVEMDRFDGK
PLINRPVADGIRKTEELINLALSGDTEVYRAANGAKAATASNEKQSLGGALYKHLMSGVSQMLPFVIGGGIMIALAFLID
GALGVPNENLGNLGSYHELASMFMKIGGAAFGLMLPVFAGYVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIPYAAGGEAT
STLAGVSSGFLGALVGGFIAGALVLAIKKYVKVPRSLEGAKSILLLPLLGTILTGFVMLAVNIPMAAINTAMNDFLGGLG
GGSAVLLGIVLGGMMAVDMGGPVNKAACVFGTGTLAATVSSGGSVAMAAVMAGGMVPPLAIFVATLLFKDKFTKEERNSG
LTNIIMGLSFITEGAIPFGAADPARAIPSFILGSAVAGGLVGLTGIKLMAPHGGIFVIALTSNALLYLVSVLVGAIVSGV
VYGYLRKPQA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=487, Percent_Identity=42.0944558521561, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1786951, Length=664, Percent_Identity=35.2409638554217, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI87082348, Length=466, Percent_Identity=33.6909871244635, Blast_Score=203, Evalue=4e-53,
Organism=Escherichia coli, GI1790386, Length=337, Percent_Identity=36.4985163204748, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788729, Length=399, Percent_Identity=29.5739348370927, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI2367327, Length=135, Percent_Identity=28.8888888888889, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790387, Length=93, Percent_Identity=40.8602150537634, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788730, Length=88, Percent_Identity=40.9090909090909, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790390, Length=63, Percent_Identity=47.6190476190476, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 66876; Mature: 66876

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTEHGYVTDFETFKEGILAREALTSTGLG
CCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
DGIAMPHSKNAAVKEATVLFAKSNKGVDYESLDGQATDLFFMIAAPEGANDTHLAALAEL
CCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHH
SQYLMKDGFADKLRQATSADQVIELFDQASEKTEELVQAPANDSGDFIVAVTACTTGIAH
HHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHH
TYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDIRKAKAIIIAADKAVEMDRFDGK
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHCEEEEECCCHHHHHCCCCC
PLINRPVADGIRKTEELINLALSGDTEVYRAANGAKAATASNEKQSLGGALYKHLMSGVS
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
QMLPFVIGGGIMIALAFLIDGALGVPNENLGNLGSYHELASMFMKIGGAAFGLMLPVFAG
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIPYAAGGEATSTLAGVSSGFLGALVGGFIA
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GALVLAIKKYVKVPRSLEGAKSILLLPLLGTILTGFVMLAVNIPMAAINTAMNDFLGGLG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
GGSAVLLGIVLGGMMAVDMGGPVNKAACVFGTGTLAATVSSGGSVAMAAVMAGGMVPPLA
CHHHHHHHHHHHHHHEEECCCCCCCCEEEEECCHHEEEECCCCHHHHHHHHHCCCCHHHH
IFVATLLFKDKFTKEERNSGLTNIIMGLSFITEGAIPFGAADPARAIPSFILGSAVAGGL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VGLTGIKLMAPHGGIFVIALTSNALLYLVSVLVGAIVSGVVYGYLRKPQA
HHHCCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTEHGYVTDFETFKEGILAREALTSTGLG
CCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
DGIAMPHSKNAAVKEATVLFAKSNKGVDYESLDGQATDLFFMIAAPEGANDTHLAALAEL
CCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHH
SQYLMKDGFADKLRQATSADQVIELFDQASEKTEELVQAPANDSGDFIVAVTACTTGIAH
HHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHH
TYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDIRKAKAIIIAADKAVEMDRFDGK
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHCEEEEECCCHHHHHCCCCC
PLINRPVADGIRKTEELINLALSGDTEVYRAANGAKAATASNEKQSLGGALYKHLMSGVS
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
QMLPFVIGGGIMIALAFLIDGALGVPNENLGNLGSYHELASMFMKIGGAAFGLMLPVFAG
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIPYAAGGEATSTLAGVSSGFLGALVGGFIA
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GALVLAIKKYVKVPRSLEGAKSILLLPLLGTILTGFVMLAVNIPMAAINTAMNDFLGGLG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
GGSAVLLGIVLGGMMAVDMGGPVNKAACVFGTGTLAATVSSGGSVAMAAVMAGGMVPPLA
CHHHHHHHHHHHHHHEEECCCCCCCCEEEEECCHHEEEECCCCHHHHHHHHHCCCCHHHH
IFVATLLFKDKFTKEERNSGLTNIIMGLSFITEGAIPFGAADPARAIPSFILGSAVAGGL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VGLTGIKLMAPHGGIFVIALTSNALLYLVSVLVGAIVSGVVYGYLRKPQA
HHHCCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]