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The map label for this gene is fba

Identifier: 116515860

GI number: 116515860

Start: 536982

End: 537863

Strand: Direct

Name: fba

Synonym: SPD_0526

Alternate gene names: 116515860

Gene position: 536982-537863 (Clockwise)

Preceding gene: 116515343

Following gene: 116517143

Centisome position: 26.24

GC content: 43.88

Gene sequence:

>882_bases
ATGGCAATCGTTTCAGCAGAAAAATTTGTCCAAGCAGCCCGTGACAACGGTTATGCAGTTGGTGGATTTAACACAAACAA
CCTTGAGTGGACTCAAGCTATCTTGCGCGCAGCAGAAGCTAAAAAAGCTCCAGTTTTGATCCAAACTTCAATGGGTGCTG
CTAAATACATGGGTGGTTACAAAGTTGCTCGCAACTTGATCGCTAACCTTGTTGAATCAATGGGTATCACTGTACCAGTA
GCTATCCACCTTGACCACGGTCACTACGAAGATGCACTTGAGTGTATCGAAGTTGGTTATACTTCAATCATGTTTGACGG
TTCACACCTTCCAGTTGAAGAAAACCTTAAATTGGCTAAAGAAGTTGTTGAAAAAGCACACGCTAAAGGTATCTCAGTAG
AAGCTGAAGTTGGTACTATCGGTGGTGAAGAAGACGGAATCATCGGTAAAGGTGAATTGGCTCCAATCGAAGACGCTAAA
GCAATGGTTGAAACTGGTATCGACTTCTTGGCAGCTGGTATCGGTAACATCCACGGCCCTTACCCAGTAAACTGGGAAGG
TCTTGACCTTGACCACTTGCAAAAATTGACAGAAGCTCTTCCAGGATTCCCAATCGTATTGCACGGTGGATCAGGTATTC
CTGATGAGCAAATCCAAGCAGCTATCAAACTTGGTGTTGCCAAAGTTAACGTTAACACAGAATGCCAAATCGCATTCGCT
AACGCAACTCGTAAATTTGCTCGTGACTACGAAGCAAACGAAGCAGAATACGACAAGAAAAAACTCTTCGACCCACGTAA
ATTCTTGGCTGACGGTGTAAAAGCTATCCAAGCATCGGTTGAAGAACGTATCGACGTATTCGGTTCAGAAGGTAAAGCAT
AA

Upstream 100 bases:

>100_bases
AATCGAAACTGCGGGAAAAACTAGATTTTTTTGGCAAAAAGTGATAAAATGAACAATGTAAATGGGATGACCCATAAAAA
TATACAGGAGGCCTGATAAA

Downstream 100 bases:

>100_bases
TCTAGCTGAATAATACAGATAAAACCTGCCTGTGAGGGTGGGTTTTTTGATTTCAAGCTACTCGTTTTAGTATAGTAAAC
TGAATCTAGACTAGCACAAT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKVARNLIANLVESMGITVPV
AIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAK
AMVETGIDFLAAGIGNIHGPYPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQIQAAIKLGVAKVNVNTECQIAFA
NATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAIQASVEERIDVFGSEGKA

Sequences:

>Translated_293_residues
MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKVARNLIANLVESMGITVPV
AIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAK
AMVETGIDFLAAGIGNIHGPYPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQIQAAIKLGVAKVNVNTECQIAFA
NATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAIQASVEERIDVFGSEGKA
>Mature_292_residues
AIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKVARNLIANLVESMGITVPVA
IHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAKA
MVETGIDFLAAGIGNIHGPYPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQIQAAIKLGVAKVNVNTECQIAFAN
ATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAIQASVEERIDVFGSEGKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family

Homologues:

Organism=Escherichia coli, GI1789526, Length=300, Percent_Identity=38.6666666666667, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI87082041, Length=300, Percent_Identity=35.6666666666667, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1788072, Length=291, Percent_Identity=35.3951890034364, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789293, Length=342, Percent_Identity=26.3157894736842, Blast_Score=94, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6322790, Length=337, Percent_Identity=28.7833827893175, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALF_STRPN (P0A4S1)

Other databases:

- EMBL:   AE005672
- PIR:   D95070
- RefSeq:   NP_345117.1
- ProteinModelPortal:   P0A4S1
- SMR:   P0A4S1
- EnsemblBacteria:   EBSTRT00000025502
- GeneID:   930553
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_0605
- TIGR:   SP_0605
- GeneTree:   EBGT00050000027845
- HOGENOM:   HBG327581
- OMA:   EYEANEA
- ProtClustDB:   PRK07315
- BioCyc:   SPNE170187-1:SP_0605-MONOMER
- BRENDA:   4.1.2.13
- GO:   GO:0006096
- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF001359
- TIGRFAMs:   TIGR00167
- TIGRFAMs:   TIGR01859

Pfam domain/function: PF01116 F_bP_aldolase

EC number: =4.1.2.13

Molecular weight: Translated: 31402; Mature: 31271

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00602 ALDOLASE_CLASS_II_1; PS00806 ALDOLASE_CLASS_II_2

Important sites: ACT_SITE 85-85 BINDING 50-50 BINDING 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGY
CCCCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHH
KVARNLIANLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLKLAK
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
EVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAKAMVETGIDFLAAGIGNIHGP
HHHHHHHHCCCEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQIQAAIKLGVAKVNVNTECQIAFA
CCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCEEEEECCCEEEEEEH
NATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAIQASVEERIDVFGSEGKA
HHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGY
CCCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHH
KVARNLIANLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLKLAK
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
EVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAKAMVETGIDFLAAGIGNIHGP
HHHHHHHHCCCEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQIQAAIKLGVAKVNVNTECQIAFA
CCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCEEEEECCCEEEEEEH
NATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAIQASVEERIDVFGSEGKA
HHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916