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The map label for this gene is coaA

Identifier: 116515774

GI number: 116515774

Start: 745650

End: 746570

Strand: Reverse

Name: coaA

Synonym: SPD_0733

Alternate gene names: 116515774

Gene position: 746570-745650 (Counterclockwise)

Preceding gene: 116515637

Following gene: 116515680

Centisome position: 36.49

GC content: 38.65

Gene sequence:

>921_bases
ATGACCAACGAATTTTTACATTTTGAAAAAATCAGCCGCCAGACTTGGCAATCTTTACATCGAAAGACAACACCTCCTTT
GACAGAAGAAGAATTGGAATCTATCAAGAGTTTTAATGACCAAATCAGTCTCCAAGACGTTACAGATATCTATCTCCCCT
TGGCTCATCTGATTCAGATTTACAAGCGAACTAAGGAAGATTTAGCCTTTTCAAAAGGAATTTTCCTCCAACGTGAAAGT
AAATCTCAACCTTTTATTATTGGGGTTTCTGGGAGTGTTGCCGTTGGAAAATCCACAACCAGTCGCCTACTTCAAATCCT
ACTGTCCCGTACGTTTACAGATGCTACGGTTGAGTTGGTTACAACTGATGGTTTTCTCTATCCCAATCAAACCTTGATTG
AGCAGGGGATTTTAAATCGTAAAGGATTTCCTGAAAGCTATGATATGGAAGCTCTTCTCAACTTCTTGGACCGCATCAAA
AATGGACAAGATGTAGATATTCCTGTCTATTCTCATGAAGTTTACGACATCGTACCCGAAGAGAAACAAAGTGTCAAAGC
TGCTGATTTTGTAATTGTTGAGGGAATCAATGTCTTTCAAAATCCACAAAACGATCGTCTCTATATCACTGACTTCTTTG
ACTTTTCCATCTATGTAGATGCTGGAGTGGATGATATTGAAAGTTGGTATCTGGACCGTTTCTTGAAAATGCTGAGTCTA
GCCCAAAACGACCCTGATAGCTACTATTATCGTTTTACTCAGATGCCGATTGGGGAAGTGGAAGCCTTTGCCCATCAGGT
CTGGACCAGTATCAATCTCACAAATCTACAAAATTATATTGAACCAACCAGAAATCGTGCAGAAGTGATTCTTCATAAAA
GCAAGAACCATGAAATCGATGAAATTTACTTAAAAAAATAA

Upstream 100 bases:

>100_bases
ATCACTTATACTATATACCATTGACTTACCACATTCAAGAAACCGCTTTATTTTTTTAGATTTTTATGGTATGATAGACA
AAATATCTAGGGGAAAACAA

Downstream 100 bases:

>100_bases
TTTTCCCTTGTCAAAACGTAAGTTTTCATATATAATGGTATAGTTAGTAAATATGGAGGTAAGAACATTGGCAAACATTA
AATCAGCTATCAAACGCGCT

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRES
KSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIK
NGQDVDIPVYSHEVYDIVPEEKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSL
AQNDPDSYYYRFTQMPIGEVEAFAHQVWTSINLTNLQNYIEPTRNRAEVILHKSKNHEIDEIYLKK

Sequences:

>Translated_306_residues
MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRES
KSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIK
NGQDVDIPVYSHEVYDIVPEEKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSL
AQNDPDSYYYRFTQMPIGEVEAFAHQVWTSINLTNLQNYIEPTRNRAEVILHKSKNHEIDEIYLKK
>Mature_305_residues
TNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESK
SQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIKN
GQDVDIPVYSHEVYDIVPEEKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSLA
QNDPDSYYYRFTQMPIGEVEAFAHQVWTSINLTNLQNYIEPTRNRAEVILHKSKNHEIDEIYLKK

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family

Homologues:

Organism=Escherichia coli, GI1790409, Length=312, Percent_Identity=42.3076923076923, Blast_Score=257, Evalue=8e-70,
Organism=Drosophila melanogaster, GI45550449, Length=220, Percent_Identity=26.3636363636364, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573516, Length=220, Percent_Identity=26.3636363636364, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573514, Length=220, Percent_Identity=26.3636363636364, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573512, Length=220, Percent_Identity=26.3636363636364, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAA_STRP2 (Q04L73)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816225.1
- ProteinModelPortal:   Q04L73
- SMR:   Q04L73
- STRING:   Q04L73
- EnsemblBacteria:   EBSTRT00000020245
- GeneID:   4441674
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_0733
- eggNOG:   COG1072
- GeneTree:   EBGT00050000027704
- HOGENOM:   HBG732538
- OMA:   GLNVLQP
- ProtClustDB:   PRK05439
- GO:   GO:0005737
- HAMAP:   MF_00215
- InterPro:   IPR004566
- InterPro:   IPR006083
- PANTHER:   PTHR10285:SF7
- PIRSF:   PIRSF000545
- TIGRFAMs:   TIGR00554

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.33

Molecular weight: Translated: 35529; Mature: 35397

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQI
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELV
HHHHHHHHHHHCCEEEEECCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCCEEEEE
TTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIKNGQDVDIPVYSHEVYDIVPE
EECCEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCCCC
EKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSL
HHHHHHHHCEEEEECCHHHCCCCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHH
AQNDPDSYYYRFTQMPIGEVEAFAHQVWTSINLTNLQNYIEPTRNRAEVILHKSKNHEID
HCCCCCHHEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCC
EIYLKK
EEEECC
>Mature Secondary Structure 
TNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQI
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELV
HHHHHHHHHHHCCEEEEECCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCCEEEEE
TTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIKNGQDVDIPVYSHEVYDIVPE
EECCEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCCCC
EKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSL
HHHHHHHHCEEEEECCHHHCCCCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHH
AQNDPDSYYYRFTQMPIGEVEAFAHQVWTSINLTNLQNYIEPTRNRAEVILHKSKNHEID
HCCCCCHHEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCC
EIYLKK
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA