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The map label for this gene is alr

Identifier: 116515765

GI number: 116515765

Start: 1530277

End: 1531380

Strand: Reverse

Name: alr

Synonym: SPD_1508

Alternate gene names: 116515765

Gene position: 1531380-1530277 (Counterclockwise)

Preceding gene: 116515875

Following gene: 116516080

Centisome position: 74.84

GC content: 46.01

Gene sequence:

>1104_bases
ATGAAAGCTAGTCCACATAGACCAACCAAGGCTCTGATTCATCTGGGAGCTATTCGACAAAATATTCAGCAAATGGGGGC
TCATATCCCTCAAGGAACGCTCAAGTTGGCTGTGGTTAAGGCCAATGCTTATGGTCATGGAGCTGTTGCCGTTGCCAAGG
CAATTCAAGATGATGTTGATGGCTTTTGCGTTTCCAATATCGATGAAGCCATTGAACTCAGACAAGCTGGACTCAGCAAG
CCAATCCTCATTTTAGGAGTTTCTGAAATCGAAGCTGTTGCTCTAGCTAAAGAATATGACTTCACCTTGACAGTGGCTGG
ACTGGAGTGGATTCAAGCACTCTTAGATAAGGAAGTGGACCTAACTGGATTGACAGTCCACCTCAAGATTGATTCAGGGA
TGGGACGGATTGGTTTTAGAGAGGCAAGTGAGGTTGAGCAGGCTCAAGATTTGCTCCAACAACACGGTGTTTGTGTTGAA
GGAATCTTTACCCACTTTGCTACTGCTGATGAGGAATCAGATGACTATTTTAATGCCCAGTTAGAACGGTTTAAAACTAT
TTTAGCTAGTATGAAGGAAGTTCCAGAGCTGGTTCATGCTAGCAATTCTGCAACGACTCTTTGGCATGTAGAGACTATTT
TCAATGCGGTTCGTATGGGAGATGCCATGTATGGTCTCAATCCAAGTGGAGCGGTCTTGGATTTGCCTTATGATTTGATA
CCGGCCTTGACCTTGGAGTCTGCTCTGGTTCATGTCAAGACAGTTCCAGCTGGAGCTTGCATGGGCTATGGAGCAACTTA
TCAAGCGGATAGCGAGCAAGTCATCGCGACCGTGCCAATCGGGTATGCAGATGGATGGACAAGAGACATGCAAAATTTCT
CTGTCTTGGTAGATGGCCAAGCTTGCCCAATTGTCGGCAGGGTTTCGATGGACCAAATCACTATTCGATTGCCTAAGCTT
TATCCGCTAGGAACCAAGGTAACCTTGATTGGCTCCAATGGGGATAAGGAAATCACTGCAACTCAGGTAGCGACCTACCG
CGTAACCATTAACTATGAGGTGGTTTGCCTCCTCAGCGACCGTATTCCGAGAGAATATTATTAG

Upstream 100 bases:

>100_bases
GCGCCTTATTTTAGTCAGGCACCATTTTCAGGAAAGATTTGGCTGTCTATCAGCCACACCGATCAGTTTGTGACAGCCAG
TGTCATTTTGGAGGAAAATC

Downstream 100 bases:

>100_bases
AAAAGAAAGGAGTGGAGCATGAATCTACATCAACCCTTGCATGTCTTGCCTGGTGTGGGACCAAAGTCAGCAGAAAAATA
CGCCAAACTAGGAATTGAAA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAYGHGAVAVAKAIQDDVDGFCVSNIDEAIELRQAGLSK
PILILGVSEIEAVALAKEYDFTLTVAGLEWIQALLDKEVDLTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVCVE
GIFTHFATADEESDDYFNAQLERFKTILASMKEVPELVHASNSATTLWHVETIFNAVRMGDAMYGLNPSGAVLDLPYDLI
PALTLESALVHVKTVPAGACMGYGATYQADSEQVIATVPIGYADGWTRDMQNFSVLVDGQACPIVGRVSMDQITIRLPKL
YPLGTKVTLIGSNGDKEITATQVATYRVTINYEVVCLLSDRIPREYY

Sequences:

>Translated_367_residues
MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAYGHGAVAVAKAIQDDVDGFCVSNIDEAIELRQAGLSK
PILILGVSEIEAVALAKEYDFTLTVAGLEWIQALLDKEVDLTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVCVE
GIFTHFATADEESDDYFNAQLERFKTILASMKEVPELVHASNSATTLWHVETIFNAVRMGDAMYGLNPSGAVLDLPYDLI
PALTLESALVHVKTVPAGACMGYGATYQADSEQVIATVPIGYADGWTRDMQNFSVLVDGQACPIVGRVSMDQITIRLPKL
YPLGTKVTLIGSNGDKEITATQVATYRVTINYEVVCLLSDRIPREYY
>Mature_367_residues
MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAYGHGAVAVAKAIQDDVDGFCVSNIDEAIELRQAGLSK
PILILGVSEIEAVALAKEYDFTLTVAGLEWIQALLDKEVDLTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVCVE
GIFTHFATADEESDDYFNAQLERFKTILASMKEVPELVHASNSATTLWHVETIFNAVRMGDAMYGLNPSGAVLDLPYDLI
PALTLESALVHVKTVPAGACMGYGATYQADSEQVIATVPIGYADGWTRDMQNFSVLVDGQACPIVGRVSMDQITIRLPKL
YPLGTKVTLIGSNGDKEITATQVATYRVTINYEVVCLLSDRIPREYY

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=365, Percent_Identity=36.1643835616438, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1790487, Length=369, Percent_Identity=31.4363143631436, Blast_Score=148, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_STRP2 (Q04J74)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816964.1
- ProteinModelPortal:   Q04J74
- SMR:   Q04J74
- STRING:   Q04J74
- EnsemblBacteria:   EBSTRT00000019591
- GeneID:   4441665
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1508
- eggNOG:   COG0787
- GeneTree:   EBGT00050000028408
- HOGENOM:   HBG712172
- OMA:   TRKEDAN
- ProtClustDB:   PRK00053
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39858; Mature: 39858

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 40-40 ACT_SITE 263-263

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAYGHGAVAVAKAIQDDVD
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCC
GFCVSNIDEAIELRQAGLSKPILILGVSEIEAVALAKEYDFTLTVAGLEWIQALLDKEVD
CHHHHCHHHHHHHHHCCCCCCEEEEEHHHHHEEHEEECCCEEEEEHHHHHHHHHHCCCCC
LTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVCVEGIFTHFATADEESDDYFNAQ
EEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHH
LERFKTILASMKEVPELVHASNSATTLWHVETIFNAVRMGDAMYGLNPSGAVLDLPYDLI
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCEEECCHHHH
PALTLESALVHVKTVPAGACMGYGATYQADSEQVIATVPIGYADGWTRDMQNFSVLVDGQ
HHHHHHHHEEEEEECCCCHHHCCCCEECCCCCCEEEEEECCCCCCCHHCCCCCEEEECCC
ACPIVGRVSMDQITIRLPKLYPLGTKVTLIGSNGDKEITATQVATYRVTINYEVVCLLSD
CCCEEECCCCCEEEEEECCEEECCCEEEEEECCCCCEEEEEEEEEEEEEEEEEEEEEEEC
RIPREYY
CCCCCCC
>Mature Secondary Structure
MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAYGHGAVAVAKAIQDDVD
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCC
GFCVSNIDEAIELRQAGLSKPILILGVSEIEAVALAKEYDFTLTVAGLEWIQALLDKEVD
CHHHHCHHHHHHHHHCCCCCCEEEEEHHHHHEEHEEECCCEEEEEHHHHHHHHHHCCCCC
LTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVCVEGIFTHFATADEESDDYFNAQ
EEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHH
LERFKTILASMKEVPELVHASNSATTLWHVETIFNAVRMGDAMYGLNPSGAVLDLPYDLI
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCEEECCHHHH
PALTLESALVHVKTVPAGACMGYGATYQADSEQVIATVPIGYADGWTRDMQNFSVLVDGQ
HHHHHHHHEEEEEECCCCHHHCCCCEECCCCCCEEEEEECCCCCCCHHCCCCCEEEECCC
ACPIVGRVSMDQITIRLPKLYPLGTKVTLIGSNGDKEITATQVATYRVTINYEVVCLLSD
CCCEEECCCCCEEEEEECCEEECCCEEEEEECCCCCEEEEEEEEEEEEEEEEEEEEEEEC
RIPREYY
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA