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The map label for this gene is wecC [H]

Identifier: 116515679

GI number: 116515679

Start: 949424

End: 950719

Strand: Direct

Name: wecC [H]

Synonym: SPD_0940

Alternate gene names: 116515679

Gene position: 949424-950719 (Clockwise)

Preceding gene: 116515758

Following gene: 116516558

Centisome position: 46.4

GC content: 30.4

Gene sequence:

>1296_bases
ATGAAAAATAATTTCCTAAGTAGAATTCAAAATAAGAAGGCAAATATTACAATTTGGGGTGCAGGATATATAGGTCTATC
TACAGCTTACCACTTTGCATTGGTAGGTTTCCGCGTCAAAATTTTTGATACTAATCATAGATTGATACAGAATTTACTTG
AAGGAAATCTGCCATTTAAAATTGATTTAGATGAAGAAATATTTAGTAAGTTAATATTTAATAAATCCATTTTACCAGAA
GTTGTAGAACATGCTGATACATATTCTGATGAGATACAAATTATCTGTATTAATACTGAAAGAAATGGAGTACCTATTAG
TAGACCATTAACTACTGTATTAGATAATATAACAACAGTATCTGAACAACTAGTTATTGTTGAAAGTACAATTTCTCCAA
ATTGGATTGATACAATTATAAGACCAAAGTTGAATGATTTGCAATATCTAACAGTTGCTCCTAGGAGAGACTGGTTTTTA
GAGACTGGATTAAATTTAAAAACACTTCCTCGAGTTATTGGTACATTGGGATCAAATTATCGTATGGAGGTTTTGAAATT
ATATGAAATGCTTTCTGATGTTGTGATTGAGGTAACTGATGCATATCACGCTTGTTTAGTAAAGGCGGTTGAAAATTCTA
TACGCTATATTAATGTTGTATTTGCTAATGAAATGATGAGAGCATTTCCAAGATATAATATGGCTGAAATTTTTGATGCT
GCTTCAACTAAGTGGAATATTCCTTATTATCATCCGTCAATTGGAATTGGAGGGTACTGTCTTCCGTTAGCTCCTAAATA
TATTTTGGATGCAGTCAATGATAGTGAGGAGTTACCTATGCTGAGGGAGTCAGTTAAATCTGATTTAAAGCAGTCTGACT
TTATTACTGACTTAATCAAAAGCTATAACTGTCAAAAAGTAGGAGTATTAGGTCTAAGTTATGCTCCGGAGACTAAAATT
TGGAAGAATTCCCCAGTTGTTAGTTTAATCTATTCTTTGTTAAGAAATGGAATAGAAGTGAAAATAAATGATCCATATTT
CTCTAGTGAAGAAATTCAAGAAATAACGACTGTTCAATCTTTCAGTTTAAATAGTGAGTCACTACAAGAATTTGATATAC
TGGTAATTGCTACCTCACATAAAAGCTATGATGGAGAATTGGAGAGAATACTTTTTGATTTAAATAAAGAAATGATTATT
TTTGATAATTTTGGAGTGAATAAGAATCTATCTAAATTACCAAATATTCATTATTTTGAAATTGGGAACTTCCAATATAA
TGAAAGTAGGAGATAA

Upstream 100 bases:

>100_bases
AAATGCTTAGGTGTACACCTAAGTCTTTAGAGTATCTAAAGCTAATTCTATTGATTATGACTAAATTATGAATAAAATAA
CGTAGAAAGTTTAACATACG

Downstream 100 bases:

>100_bases
AGTGAAAAAAGCATTAATAATTACTGCCCATCCAGATGATGCTGAAATTTCTATGGGTGGACATATAATTAATATGGTTA
ATAATGGTTATTATGTCAAA

Product: UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKNNFLSRIQNKKANITIWGAGYIGLSTAYHFALVGFRVKIFDTNHRLIQNLLEGNLPFKIDLDEEIFSKLIFNKSILPE
VVEHADTYSDEIQIICINTERNGVPISRPLTTVLDNITTVSEQLVIVESTISPNWIDTIIRPKLNDLQYLTVAPRRDWFL
ETGLNLKTLPRVIGTLGSNYRMEVLKLYEMLSDVVIEVTDAYHACLVKAVENSIRYINVVFANEMMRAFPRYNMAEIFDA
ASTKWNIPYYHPSIGIGGYCLPLAPKYILDAVNDSEELPMLRESVKSDLKQSDFITDLIKSYNCQKVGVLGLSYAPETKI
WKNSPVVSLIYSLLRNGIEVKINDPYFSSEEIQEITTVQSFSLNSESLQEFDILVIATSHKSYDGELERILFDLNKEMII
FDNFGVNKNLSKLPNIHYFEIGNFQYNESRR

Sequences:

>Translated_431_residues
MKNNFLSRIQNKKANITIWGAGYIGLSTAYHFALVGFRVKIFDTNHRLIQNLLEGNLPFKIDLDEEIFSKLIFNKSILPE
VVEHADTYSDEIQIICINTERNGVPISRPLTTVLDNITTVSEQLVIVESTISPNWIDTIIRPKLNDLQYLTVAPRRDWFL
ETGLNLKTLPRVIGTLGSNYRMEVLKLYEMLSDVVIEVTDAYHACLVKAVENSIRYINVVFANEMMRAFPRYNMAEIFDA
ASTKWNIPYYHPSIGIGGYCLPLAPKYILDAVNDSEELPMLRESVKSDLKQSDFITDLIKSYNCQKVGVLGLSYAPETKI
WKNSPVVSLIYSLLRNGIEVKINDPYFSSEEIQEITTVQSFSLNSESLQEFDILVIATSHKSYDGELERILFDLNKEMII
FDNFGVNKNLSKLPNIHYFEIGNFQYNESRR
>Mature_431_residues
MKNNFLSRIQNKKANITIWGAGYIGLSTAYHFALVGFRVKIFDTNHRLIQNLLEGNLPFKIDLDEEIFSKLIFNKSILPE
VVEHADTYSDEIQIICINTERNGVPISRPLTTVLDNITTVSEQLVIVESTISPNWIDTIIRPKLNDLQYLTVAPRRDWFL
ETGLNLKTLPRVIGTLGSNYRMEVLKLYEMLSDVVIEVTDAYHACLVKAVENSIRYINVVFANEMMRAFPRYNMAEIFDA
ASTKWNIPYYHPSIGIGGYCLPLAPKYILDAVNDSEELPMLRESVKSDLKQSDFITDLIKSYNCQKVGVLGLSYAPETKI
WKNSPVVSLIYSLLRNGIEVKINDPYFSSEEIQEITTVQSFSLNSESLQEFDILVIATSHKSYDGELERILFDLNKEMII
FDNFGVNKNLSKLPNIHYFEIGNFQYNESRR

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 49387; Mature: 49387

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNFLSRIQNKKANITIWGAGYIGLSTAYHFALVGFRVKIFDTNHRLIQNLLEGNLPFK
CCCHHHHHHCCCCCCEEEEECCHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHCCCCCEE
IDLDEEIFSKLIFNKSILPEVVEHADTYSDEIQIICINTERNGVPISRPLTTVLDNITTV
EECCHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHH
SEQLVIVESTISPNWIDTIIRPKLNDLQYLTVAPRRDWFLETGLNLKTLPRVIGTLGSNY
CCEEEEEEECCCCHHHHHHHCCCCCCCEEEEECCCCCCHHHCCCCHHHHHHHHHHCCCCC
RMEVLKLYEMLSDVVIEVTDAYHACLVKAVENSIRYINVVFANEMMRAFPRYNMAEIFDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCHHHHHHC
ASTKWNIPYYHPSIGIGGYCLPLAPKYILDAVNDSEELPMLRESVKSDLKQSDFITDLIK
CCCCCCCCEECCCCCCCCEEHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SYNCQKVGVLGLSYAPETKIWKNSPVVSLIYSLLRNGIEVKINDPYFSSEEIQEITTVQS
CCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
FSLNSESLQEFDILVIATSHKSYDGELERILFDLNKEMIIFDNFGVNKNLSKLPNIHYFE
CCCCHHHHHHEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHCCCEEEEE
IGNFQYNESRR
ECCEECCCCCC
>Mature Secondary Structure
MKNNFLSRIQNKKANITIWGAGYIGLSTAYHFALVGFRVKIFDTNHRLIQNLLEGNLPFK
CCCHHHHHHCCCCCCEEEEECCHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHCCCCCEE
IDLDEEIFSKLIFNKSILPEVVEHADTYSDEIQIICINTERNGVPISRPLTTVLDNITTV
EECCHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHH
SEQLVIVESTISPNWIDTIIRPKLNDLQYLTVAPRRDWFLETGLNLKTLPRVIGTLGSNY
CCEEEEEEECCCCHHHHHHHCCCCCCCEEEEECCCCCCHHHCCCCHHHHHHHHHHCCCCC
RMEVLKLYEMLSDVVIEVTDAYHACLVKAVENSIRYINVVFANEMMRAFPRYNMAEIFDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCHHHHHHC
ASTKWNIPYYHPSIGIGGYCLPLAPKYILDAVNDSEELPMLRESVKSDLKQSDFITDLIK
CCCCCCCCEECCCCCCCCEEHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SYNCQKVGVLGLSYAPETKIWKNSPVVSLIYSLLRNGIEVKINDPYFSSEEIQEITTVQS
CCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
FSLNSESLQEFDILVIATSHKSYDGELERILFDLNKEMIIFDNFGVNKNLSKLPNIHYFE
CCCCHHHHHHEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHCCCEEEEE
IGNFQYNESRR
ECCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA