The gene/protein map for NC_008533 is currently unavailable.
Definition Streptococcus pneumoniae D39, complete genome.
Accession NC_008533
Length 2,046,115

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The map label for this gene is ldh

Identifier: 116515602

GI number: 116515602

Start: 1105656

End: 1106642

Strand: Direct

Name: ldh

Synonym: SPD_1078

Alternate gene names: 116515602

Gene position: 1105656-1106642 (Clockwise)

Preceding gene: 116516787

Following gene: 116516176

Centisome position: 54.04

GC content: 41.84

Gene sequence:

>987_bases
ATGACTTCAACTAAACAACACAAAAAAGTTATCCTTGTCGGTGATGGTGCTGTAGGTTCATCTTACGCTTTTGCACTTGT
TAACCAAGGAATTGCACAAGAGCTTGGAATTATCGAAATTCCACAATTGCATGAAAAAGCTGTTGGTGATGCGCTTGACC
TTAGTCACGCCCTTGCCTTCACTTCACCTAAAAAAATCTATGCAGCTCAATACTCTGACTGTGCAGACGCTGACCTTGTT
GTAATCACTGCAGGTGCACCTCAAAAACCAGGTGAAACTCGTCTTGACCTTGTAGGTAAAAACCTTGCTATCAACAAATC
AATCGTAACTCAAGTTGTTGAATCTGGTTTCAAAGGTATCTTCCTTGTTGCTGCTAACCCAGTTGACGTTTTGACTTACT
CAACTTGGAAATTCTCTGGTTTCCCTAAAGAACGCGTTATCGGTTCAGGTACTTCACTTGACTCAGCTCGTTTCCGTCAA
GCACTTGCTGAAAAATTGGATGTGGATGCTCGTTCAGTGCACGCCTACATCATGGGTGAACACGGTGACTCTGAGTTCGC
TGTTTGGTCACACGCTAACATCGCTGGTGTAAACCTTGAAGAATTCCTTAAAGACACTCAAAATGTTCAAGAAGCTGAAT
TGATTGAATTGTTCGAAGGTGTTCGTGATGCAGCCTACACAATCATCAACAAAAAAGGTGCAACATACTACGGTATCGCA
GTAGCCCTTGCTCGTATCACTAAAGCAATCCTTGACGATGAAAACGCAGTACTTCCACTTTCAGTATTCCAAGAAGGTCA
ATACGGAGTTGAGAATGTCTTTATCGGTCAACCAGCTGTTGTTGGTGCACATGGTATCGTTCGTCCAGTAAACATTCCAT
TGAACGATGCAGAAACTCAAAAAATGCAAGCATCTGCTAAAGAATTGCAAGCTATTATTGACGAAGCATGGAAAAATCCA
GAATTCCAAGAAGCTTCTAAAAACTAA

Upstream 100 bases:

>100_bases
GAGAACTATAAGGCATATTCGTGACAAAGTTTTTTAAAAGTGATAGAATGAAGTTGTCTAGGGAAAATCCCCTAATAAAA
TTAAGGAGATGTTTAAAACA

Downstream 100 bases:

>100_bases
TTTAACTATAGACAACTCCTTGAATCATCAGGGAGTTGTTTTTTATCTATATGATATAGTCTATTGAAGTTAGAGTAGTA
CACAACTGCTTCTAAGATCT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLHEKAVGDALDLSHALAFTSPKKIYAAQYSDCADADLV
VITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQ
ALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELFEGVRDAAYTIINKKGATYYGIA
VALARITKAILDDENAVLPLSVFQEGQYGVENVFIGQPAVVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNP
EFQEASKN

Sequences:

>Translated_328_residues
MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLHEKAVGDALDLSHALAFTSPKKIYAAQYSDCADADLV
VITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQ
ALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELFEGVRDAAYTIINKKGATYYGIA
VALARITKAILDDENAVLPLSVFQEGQYGVENVFIGQPAVVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNP
EFQEASKN
>Mature_327_residues
TSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLHEKAVGDALDLSHALAFTSPKKIYAAQYSDCADADLVV
ITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQA
LAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELFEGVRDAAYTIINKKGATYYGIAV
ALARITKAILDDENAVLPLSVFQEGQYGVENVFIGQPAVVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNPE
FQEASKN

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family

Homologues:

Organism=Homo sapiens, GI291575128, Length=313, Percent_Identity=39.6166134185303, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI4557032, Length=313, Percent_Identity=39.6166134185303, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI15082234, Length=310, Percent_Identity=38.7096774193548, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI47059044, Length=313, Percent_Identity=38.6581469648562, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI221136809, Length=313, Percent_Identity=38.6581469648562, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI5031857, Length=310, Percent_Identity=39.0322580645161, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI260099723, Length=310, Percent_Identity=39.0322580645161, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI9257228, Length=307, Percent_Identity=40.0651465798046, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4504973, Length=307, Percent_Identity=40.0651465798046, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI260099725, Length=229, Percent_Identity=41.4847161572052, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI260099727, Length=206, Percent_Identity=43.6893203883495, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI207028494, Length=236, Percent_Identity=36.864406779661, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI103472011, Length=310, Percent_Identity=26.1290322580645, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI103472015, Length=206, Percent_Identity=29.126213592233, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI21735621, Length=328, Percent_Identity=26.219512195122, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17535107, Length=291, Percent_Identity=43.6426116838488, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17554310, Length=325, Percent_Identity=27.3846153846154, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136226, Length=301, Percent_Identity=39.5348837209302, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI45550422, Length=305, Percent_Identity=32.4590163934426, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24647881, Length=323, Percent_Identity=27.8637770897833, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): LDH_STRP2 (Q04K99)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816549.1
- ProteinModelPortal:   Q04K99
- SMR:   Q04K99
- STRING:   Q04K99
- PhosSite:   Q04K99
- EnsemblBacteria:   EBSTRT00000020345
- GeneID:   4442741
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1078
- eggNOG:   COG0039
- GeneTree:   EBGT00050000027058
- HOGENOM:   HBG566126
- OMA:   MDLNHGV
- ProtClustDB:   PRK00066
- GO:   GO:0005737
- GO:   GO:0005488
- GO:   GO:0006096
- HAMAP:   MF_00488
- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.90.110.10
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000102
- PRINTS:   PR00086
- TIGRFAMs:   TIGR01771

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N; SSF56327 Lactate_DH/Glyco_hydro_4_C

EC number: =1.1.1.27

Molecular weight: Translated: 35355; Mature: 35224

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00064 L_LDH

Important sites: ACT_SITE 181-181 BINDING 94-94 BINDING 126-126 BINDING 157-157 BINDING 235-235

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLHEKAVGDALDLSHALAF
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCHHHHHHHCCHHHHHHHHHH
TSPKKIYAAQYSDCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFKGI
CCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCHHEECCCCEECHHHHHHHHHCCCCEE
FLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAEKLDVDARSVHAYIMGE
EEEECCCCCEEEEECEEECCCCHHHEECCCCCCCHHHHHHHHHHHHCCCHHEEEEEEEEC
HGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELFEGVRDAAYTIINKKGATYYGIA
CCCCCEEEEECCCEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHH
VALARITKAILDDENAVLPLSVFQEGQYGVENVFIGQPAVVGAHGIVRPVNIPLNDAETQ
HHHHHHHHHHHCCCCCEEEHHHHCCCCCCCCEEEECCCCEECCCCCEEEECCCCCCCHHH
KMQASAKELQAIIDEAWKNPEFQEASKN
HHHHHHHHHHHHHHHHHCCCCHHHCCCC
>Mature Secondary Structure 
TSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLHEKAVGDALDLSHALAF
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCHHHHHHHCCHHHHHHHHHH
TSPKKIYAAQYSDCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFKGI
CCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCHHEECCCCEECHHHHHHHHHCCCCEE
FLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAEKLDVDARSVHAYIMGE
EEEECCCCCEEEEECEEECCCCHHHEECCCCCCCHHHHHHHHHHHHCCCHHEEEEEEEEC
HGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELFEGVRDAAYTIINKKGATYYGIA
CCCCCEEEEECCCEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHH
VALARITKAILDDENAVLPLSVFQEGQYGVENVFIGQPAVVGAHGIVRPVNIPLNDAETQ
HHHHHHHHHHHCCCCCEEEHHHHCCCCCCCCEEEECCCCEECCCCCEEEECCCCCCCHHH
KMQASAKELQAIIDEAWKNPEFQEASKN
HHHHHHHHHHHHHHHHHCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA