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The map label for this gene is msrAB2

Identifier: 116515600

GI number: 116515600

Start: 594649

End: 595584

Strand: Direct

Name: msrAB2

Synonym: SPD_0573

Alternate gene names: 116515600

Gene position: 594649-595584 (Clockwise)

Preceding gene: 116517064

Following gene: 116516390

Centisome position: 29.06

GC content: 42.74

Gene sequence:

>936_bases
TTGCACGAAATTTATCTAGCTGGAGGTTGTTTCTGGGGAGTGGAGGAATATTTCTCACGTGTTCCCGGGGTGACGGATGC
CGTTTCAGGCTATGCAAATGGTAGAGGAGAAACAACCAAGTACGAATTGATTAACCAAACAGGTCATGCAGAAACCGTCC
ATGTCACCTATGATGCCAAGCAAATTTCTCTCAAGGAAATCCTGCTTCACTATTTCCGCATTATCAATCCAACCAGCAAA
AATAAACAAGGAAATGATGTGGGGACCCAGTACCGTACTGGTGTTTATTACACAGATGACAAGGATTTGGAAGTGATTAA
CCAAGTCTTTGATGAGGTGGCTAAGAAATACGATCAACCTCTAGCAGTTGAAAAGGAAAACTTGAAGAATTTTGTGGTGG
CTGAGGATTACCATCAAGACTATCTCAAGAAAAATCCAAATGGCTACTGCCATATCAATGTTAATCAGGCGGCCTATCCT
GTCATTGATGCCAGCAAATATCCAAAACCAAGTGATGAGGAATTGAAAAAGACCCTGTCACCTGAGGAGTATGCAGTTAC
CCAGGAAAATCAAACAGAACGAGCTTTCTCAAACCGTTACTGGGATAAATTTGAATCCGGTATCTATGTGGATATAGCAA
CTGGGGAACCTCTCTTTTCATCAAAAGACAAATTTGAGTCTGGTTGTGGCTGGCCTAGTTTTACCCAACCCATCAGTCCA
GATGTTGTCACCTACAAGGAAGATAAGTCCTACAATATGACGCGTATGGAAGTGCGGAGCCGAGTAGGAGATTCTCACCT
TGGGCATGTCTTTACGGATGGTCCACAGGACAAGGGCGGCTTACGTTACTGTATCAATAGCCTCTCTATCCGCTTTATTC
CCAAAGACCAAATGGAAGAAAAAGGCTACGCTTATTTACTAGATTATGTTGATTAA

Upstream 100 bases:

>100_bases
ACGAAATGCAGGGCAGACAGATGCCTCGCAAATTGAAAAGGCGGCAGTTAGCCAAGGAGGAAAAGCAGTGAAAAAAACAG
AAATTAGTAAAGACGCAGAC

Downstream 100 bases:

>100_bases
TACTCTTCGAAAATCTCTTCAAACCACGTCAGCGTCGCCTTACCGTATGTAGGGTTACTGACTTCGTCAGTTTTATCTAC
AACCTCAAAGCTATACTTTG

Product: bifunctional methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSK
NKQGNDVGTQYRTGVYYTDDKDLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYP
VIDASKYPKPSDEELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISP
DVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD

Sequences:

>Translated_311_residues
MHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSK
NKQGNDVGTQYRTGVYYTDDKDLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYP
VIDASKYPKPSDEELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISP
DVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD
>Mature_311_residues
MHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSK
NKQGNDVGTQYRTGVYYTDDKDLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYP
VIDASKYPKPSDEELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISP
DVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=126, Percent_Identity=46.8253968253968, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI301336162, Length=126, Percent_Identity=46.8253968253968, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI73089054, Length=126, Percent_Identity=46.8253968253968, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI37620216, Length=126, Percent_Identity=46.8253968253968, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=37.1069182389937, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=37.1069182389937, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI117606353, Length=132, Percent_Identity=39.3939393939394, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI208609993, Length=129, Percent_Identity=37.2093023255814, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1788077, Length=132, Percent_Identity=47.7272727272727, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=38, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI115532676, Length=137, Percent_Identity=42.3357664233577, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17553450, Length=137, Percent_Identity=42.3357664233577, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=39.7435897435897, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319816, Length=130, Percent_Identity=34.6153846153846, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221378664, Length=122, Percent_Identity=47.5409836065574, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI45553335, Length=125, Percent_Identity=46.4, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356369, Length=125, Percent_Identity=46.4, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221378662, Length=129, Percent_Identity=44.9612403100775, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645799, Length=125, Percent_Identity=46.4, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645804, Length=136, Percent_Identity=42.6470588235294, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24645801, Length=136, Percent_Identity=42.6470588235294, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSAB2_STRPN (P65443)

Other databases:

- EMBL:   AE005672
- PIR:   D95076
- RefSeq:   NP_345165.1
- ProteinModelPortal:   P65443
- EnsemblBacteria:   EBSTRT00000026329
- GeneID:   930609
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_0660
- TIGR:   SP_0660
- GeneTree:   EBGT00050000027538
- HOGENOM:   HBG715255
- OMA:   GIYYTDK
- ProtClustDB:   CLSK2752092
- BioCyc:   SPNE170187-1:SP_0660-MONOMER
- BRENDA:   1.8.4.11
- BRENDA:   1.8.4.12
- HAMAP:   MF_01400
- HAMAP:   MF_01401
- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00401
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01625 PMSR; PF01641 SelR; SSF55068 MsrA; SSF51316 Mss4_like

EC number: =1.8.4.11; =1.8.4.12

Molecular weight: Translated: 35610; Mature: 35610

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 284-284

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAK
CCEEEEECCCHHCHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHCCCCCCEEEEEEECCH
QISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDKDLEVINQVFDEVAKKYDQP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCEEEECCCHHHHHHHHHHHHHHHCCCC
LAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYPVIDASKYPKPSDEELKKTLS
CCEEHHCCCCEEEECHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCCCCHHHHHHHCC
PEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISP
CCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCC
DVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEE
CEEEEECCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHCCEEEEECHHHHCC
KGYAYLLDYVD
CCCEEEEEECC
>Mature Secondary Structure
MHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAK
CCEEEEECCCHHCHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHCCCCCCEEEEEEECCH
QISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDKDLEVINQVFDEVAKKYDQP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCEEEECCCHHHHHHHHHHHHHHHCCCC
LAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYPVIDASKYPKPSDEELKKTLS
CCEEHHCCCCEEEECHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCCCCHHHHHHHCC
PEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISP
CCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCC
DVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEE
CEEEEECCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHCCEEEEECHHHHCC
KGYAYLLDYVD
CCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916