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The map label for this gene is scrR [H]

Identifier: 116515545

GI number: 116515545

Start: 1602963

End: 1603958

Strand: Reverse

Name: scrR [H]

Synonym: SPD_1586

Alternate gene names: 116515545

Gene position: 1603958-1602963 (Counterclockwise)

Preceding gene: 116516300

Following gene: 116516945

Centisome position: 78.39

GC content: 30.52

Gene sequence:

>996_bases
ATGGTAGAACAAAGAAAATCAATTACCATGAAAGATGTTGCTTTAGAAGCAGGAGTTAGTGTTGGAACTGTTTCACGTGT
AATTAATAAAGAAAAAGGCATTAAAGAAGTAACTTTAAGGAAAGTTCAAAGGGCTATAAAAACATTGGACTATATCCCTG
ATAATTATGCTCGAGGTATGAAAAAGAATAGAACAGAAACTATCGCTTTGATTATTCCGAGCATATGGCATCCATTTTTT
TCGGAGTTTGCCTATCATGTTGAGAAAGAGTTATTAAAATATAATTATAAATTATTTATTTGTAACGCTGATAGCGATTC
ACAAAATGAAATCGAATATATCGAAATGTTGAAACAAAATAAAGTGGATGGAATTATTGGTATTACATATTCTGATATTG
ACAAATATATTTTATCTGATTTACCGTTTGTAAGTATAGATAGACATTTTTCGGAAAATGTATGCTATGTTACTTCAGCA
AATTACAAAGGAGGACAAACTGCAGCAGAGGAACTGGTTAGAAGGGATAATAAGCACCTTGCTTTTATTGGTTCAATTAA
TATGTATGAGAATGAGACTATACTCAGAAGTAAAGGATTCAGAGAAAAAGCTAAGGAATTAGGAGTAGATGTCTATAATT
TTGAAATGAAAGAACCTTTAATAAATCCTGAAGATCAGATAAGAATTTTTTTGCAATCTCATAAAGAAATTGATGGTATA
TTTACAATAAATGATATGATGGCTCTGAGAGTTATTAGTGTTATGAAAGAACTGGGGAAAATAGCACCTGATGATTACCA
GATAATTGGGTTTGATGGTTTAAAAACTTCTGTCGATCAATCTTATCTAGTGTCTACAATAGTTCAAGATATTGGTATGA
TGGCAAAAGAATCTGTTGCAATGATACTGAAAATGATTAAGCGAGAAGAGATTCTAGAAAAACGAATCGTAATTCCCACA
TATTTTTGGGGAGATAAAACAACAAAAAAAATTTAA

Upstream 100 bases:

>100_bases
TTTTATTCATGATGGGATAAATGATCTGGCCAAAAATGATTGAGAAATAGTTGCTTAAAAAGCATTTGCATGATACTATA
TATTGAAAGGAGTTGATAAT

Downstream 100 bases:

>100_bases
AAAGCGCTTGACAATTAATGAAAGCGCTGTTATAATATAATCAACAAATGAAACGTTTCAAAAATAGGCTAGAAGCTTGT
TTAAAAAATAAATAAAAAAT

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: Scr operon regulatory protein [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLRKVQRAIKTLDYIPDNYARGMKKNRTETIALIIPSIWHPFF
SEFAYHVEKELLKYNYKLFICNADSDSQNEIEYIEMLKQNKVDGIIGITYSDIDKYILSDLPFVSIDRHFSENVCYVTSA
NYKGGQTAAEELVRRDNKHLAFIGSINMYENETILRSKGFREKAKELGVDVYNFEMKEPLINPEDQIRIFLQSHKEIDGI
FTINDMMALRVISVMKELGKIAPDDYQIIGFDGLKTSVDQSYLVSTIVQDIGMMAKESVAMILKMIKREEILEKRIVIPT
YFWGDKTTKKI

Sequences:

>Translated_331_residues
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLRKVQRAIKTLDYIPDNYARGMKKNRTETIALIIPSIWHPFF
SEFAYHVEKELLKYNYKLFICNADSDSQNEIEYIEMLKQNKVDGIIGITYSDIDKYILSDLPFVSIDRHFSENVCYVTSA
NYKGGQTAAEELVRRDNKHLAFIGSINMYENETILRSKGFREKAKELGVDVYNFEMKEPLINPEDQIRIFLQSHKEIDGI
FTINDMMALRVISVMKELGKIAPDDYQIIGFDGLKTSVDQSYLVSTIVQDIGMMAKESVAMILKMIKREEILEKRIVIPT
YFWGDKTTKKI
>Mature_331_residues
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLRKVQRAIKTLDYIPDNYARGMKKNRTETIALIIPSIWHPFF
SEFAYHVEKELLKYNYKLFICNADSDSQNEIEYIEMLKQNKVDGIIGITYSDIDKYILSDLPFVSIDRHFSENVCYVTSA
NYKGGQTAAEELVRRDNKHLAFIGSINMYENETILRSKGFREKAKELGVDVYNFEMKEPLINPEDQIRIFLQSHKEIDGI
FTINDMMALRVISVMKELGKIAPDDYQIIGFDGLKTSVDQSYLVSTIVQDIGMMAKESVAMILKMIKREEILEKRIVIPT
YFWGDKTTKKI

Specific function: Negative regulator of scrB expression [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=324, Percent_Identity=28.3950617283951, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787948, Length=318, Percent_Identity=29.874213836478, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790369, Length=338, Percent_Identity=26.3313609467456, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789202, Length=273, Percent_Identity=27.8388278388278, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786268, Length=281, Percent_Identity=26.3345195729537, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788474, Length=320, Percent_Identity=23.75, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI48994940, Length=280, Percent_Identity=23.2142857142857, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789068, Length=311, Percent_Identity=22.508038585209, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787906, Length=338, Percent_Identity=21.8934911242604, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790715, Length=325, Percent_Identity=26.7692307692308, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790192, Length=271, Percent_Identity=23.9852398523985, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787580, Length=154, Percent_Identity=29.2207792207792, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38116; Mature: 38116

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLRKVQRAIKTLDYIPDNYARGM
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHCC
KKNRTETIALIIPSIWHPFFSEFAYHVEKELLKYNYKLFICNADSDSQNEIEYIEMLKQN
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC
KVDGIIGITYSDIDKYILSDLPFVSIDRHFSENVCYVTSANYKGGQTAAEELVRRDNKHL
CCCEEEEEEHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCE
AFIGSINMYENETILRSKGFREKAKELGVDVYNFEMKEPLINPEDQIRIFLQSHKEIDGI
EEEEECEECCCCHHHHHCCHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCE
FTINDMMALRVISVMKELGKIAPDDYQIIGFDGLKTSVDQSYLVSTIVQDIGMMAKESVA
EEHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MILKMIKREEILEKRIVIPTYFWGDKTTKKI
HHHHHHHHHHHHHHCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLRKVQRAIKTLDYIPDNYARGM
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHCC
KKNRTETIALIIPSIWHPFFSEFAYHVEKELLKYNYKLFICNADSDSQNEIEYIEMLKQN
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC
KVDGIIGITYSDIDKYILSDLPFVSIDRHFSENVCYVTSANYKGGQTAAEELVRRDNKHL
CCCEEEEEEHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCE
AFIGSINMYENETILRSKGFREKAKELGVDVYNFEMKEPLINPEDQIRIFLQSHKEIDGI
EEEEECEECCCCHHHHHCCHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCE
FTINDMMALRVISVMKELGKIAPDDYQIIGFDGLKTSVDQSYLVSTIVQDIGMMAKESVA
EEHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MILKMIKREEILEKRIVIPTYFWGDKTTKKI
HHHHHHHHHHHHHHCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9673256; 12397186 [H]