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The map label for this gene is saeS [H]

Identifier: 116515418

GI number: 116515418

Start: 84533

End: 85585

Strand: Direct

Name: saeS [H]

Synonym: SPD_0082

Alternate gene names: 116515418

Gene position: 84533-85585 (Clockwise)

Preceding gene: 116516719

Following gene: 116516581

Centisome position: 4.13

GC content: 43.97

Gene sequence:

>1053_bases
ATGAAACTAAAAAGTTATATTTTGGTTGGATATATTATTTCAACCCTCTTAACCATTTTGGTTGTTTTTTGGGCTGTTCA
AAAAATGCTGATTGCGAAAGGCGAGATTTACTTTTTGCTTGGGATGACCATCGTTGCCAGCCTTGTCGGTGCTGGGATTA
GTCTCTTTCTCCTATTGCCAGTCTTTACGTCGTTGGGCAAACTCAAGGAGCATGCCAAGCGGGTAGCGGCCAAGGATTTT
CCTTCAAATTTGGAGGTTCAAGGTCCTGTAGAATTTCAGCAATTAGGGCAAACTTTTAATGAGATGTCCCATGATTTGCA
GGTAAGCTTTGATTCCTTGGAAGAAAGCGAACGAGAAAAGGGCTTGATGATTGCCCAGTTGTCGCATGATATTAAGACCC
CTATCACTTCGATTCAAGCGACGGTAGAAGGGATTTTGGATGGGATTATCAAGGAGTCGGAGCAAGCTCATTATCTAGCA
ACCATTGGACGCCAGACGGAGAGGCTCAATAAACTGGTTGAGGAGTTGAATTTTTTGACCCTAAACACAGCTAGAAATCA
GGTGGAAACTACCAGTAAAGACAGTATTTTTCTGGACAAGCTCTTAATTGAGTGCATGAGTGAATTTCAGTTTTTGATTG
AGCAGGAGAGAAGAGATGTCCACTTGCAGGTAATCCCAGAGTCTGCCCGGATTGAGGGAGATTATGCTAAGCTTTCTCGT
ATCTTGGTGAATCTGGTCGATAACGCTTTTAAATATTCTGCTCCAGGAACCAAGCTGGAAGTGGTGGCTAAGCTGGAGAA
GGACCAGCTTTCAATCAGTGTGACCGATGAAGGGCAGGGTATTGCCCCAGAGGATTTGGAAAATATTTTCAAACGTCTTT
ATCGTGTCGAAACTTCGCGTAACATGAAGACAGGTGGTCATGGATTAGGACTTGCGATTGCGCGTGAATTGGCCCATCAA
TTGGGTGGGGAAATCACAGTCAGCAGCCAGTACGGTCTAGGAAGTACCTTTACCCTCGTTCTCAACCTCTCTGGTAGTGA
AAATAAAGCCTAA

Upstream 100 bases:

>100_bases
CTCTTCGACAGGAGCTGGCAAAATATAGTAGTGACCAAACGCCCACTATTAAGACAGTTTGGGGGTTGGGATATAAGATA
GAGAAACCGAGAGGACAAAC

Downstream 100 bases:

>100_bases
AACCCCTTTACAAATCCAGCTATTCATGGTAGAATAGATTTTGTGTGAAATATCAGCAGGAAAGCATGAAGCTCGTCAAC
AGGTGTCTTATGACAAGTAA

Product: sensor histidine kinase

Products: NA

Alternate protein names: Sensor protein saeS [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTIVASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDF
PSNLEVQGPVEFQQLGQTFNEMSHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLA
TIGRQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERRDVHLQVIPESARIEGDYAKLSR
ILVNLVDNAFKYSAPGTKLEVVAKLEKDQLSISVTDEGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLAIARELAHQ
LGGEITVSSQYGLGSTFTLVLNLSGSENKA

Sequences:

>Translated_350_residues
MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTIVASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDF
PSNLEVQGPVEFQQLGQTFNEMSHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLA
TIGRQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERRDVHLQVIPESARIEGDYAKLSR
ILVNLVDNAFKYSAPGTKLEVVAKLEKDQLSISVTDEGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLAIARELAHQ
LGGEITVSSQYGLGSTFTLVLNLSGSENKA
>Mature_350_residues
MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTIVASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDF
PSNLEVQGPVEFQQLGQTFNEMSHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLA
TIGRQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERRDVHLQVIPESARIEGDYAKLSR
ILVNLVDNAFKYSAPGTKLEVVAKLEKDQLSISVTDEGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLAIARELAHQ
LGGEITVSSQYGLGSTFTLVLNLSGSENKA

Specific function: Member of the two-component regulatory system saeR/saeS. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator saeR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=260, Percent_Identity=29.6153846153846, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788393, Length=291, Percent_Identity=27.4914089347079, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=33.0508474576271, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786783, Length=304, Percent_Identity=27.3026315789474, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1787894, Length=321, Percent_Identity=26.1682242990654, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=29.2792792792793, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=31.0344827586207, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790861, Length=292, Percent_Identity=25.6849315068493, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=27.1255060728745, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789808, Length=306, Percent_Identity=24.5098039215686, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=252, Percent_Identity=25, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788279, Length=287, Percent_Identity=25.4355400696864, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=26.6949152542373, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=29.004329004329, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082128, Length=257, Percent_Identity=25.2918287937743, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=221, Percent_Identity=25.7918552036199, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=25.1046025104602, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38847; Mature: 38847

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTIVASLVGAGISLFLLLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VFTSLGKLKEHAKRVAAKDFPSNLEVQGPVEFQQLGQTFNEMSHDLQVSFDSLEESEREK
HHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHCHHHEEEHHHHHHHHHHC
GLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLATIGRQTERLNKLVEELNFLT
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEE
LNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERRDVHLQVIPESARIEGDYAKLSR
EECHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHH
ILVNLVDNAFKYSAPGTKLEVVAKLEKDQLSISVTDEGQGIAPEDLENIFKRLYRVETSR
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
NMKTGGHGLGLAIARELAHQLGGEITVSSQYGLGSTFTLVLNLSGSENKA
CCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure
MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTIVASLVGAGISLFLLLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VFTSLGKLKEHAKRVAAKDFPSNLEVQGPVEFQQLGQTFNEMSHDLQVSFDSLEESEREK
HHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHCHHHEEEHHHHHHHHHHC
GLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLATIGRQTERLNKLVEELNFLT
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEE
LNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERRDVHLQVIPESARIEGDYAKLSR
EECHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHH
ILVNLVDNAFKYSAPGTKLEVVAKLEKDQLSISVTDEGQGIAPEDLENIFKRLYRVETSR
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
NMKTGGHGLGLAIARELAHQLGGEITVSSQYGLGSTFTLVLNLSGSENKA
CCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA