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The map label for this gene is dltA

Identifier: 116494338

GI number: 116494338

Start: 789884

End: 791404

Strand: Direct

Name: dltA

Synonym: LSEI_0794

Alternate gene names: 116494338

Gene position: 789884-791404 (Clockwise)

Preceding gene: 116494337

Following gene: 116494339

Centisome position: 27.28

GC content: 46.55

Gene sequence:

>1521_bases
ATGATCGATAATGTGATTACTGCGATCGATCGGGTCGCCGCGGAACATCCAACGCGCGTTGCTTACGATTATGAAGGCAC
ACAGTACACTTACGCACAATTAAAAGAAGGTAGCGATCGCTTGGCAGGCTTTTTTGCTGAAACCTTGCCTGAGCATGAGC
CGATCATTGTTTATGGCGGTCAGACTTTCGATATGGTCGAGGTTTTCCTGGGCCTTTCCAAGTCTGGGCATGCATACATT
CCGATTGATACCCATAGCCCCAATGAGCGGATCACGCAGGTGCAGGATGTTGCCCATACACCGGCTATCATCGAAGTAGC
ACCTTTGCCGATTGCGGTTCCGGATGTTCAGATTATTCGCGCACCAGCGTTGCATGAAGCTGAGAAGACGCATGCACCCA
TTAGTTCATTGCAACATGCGGTCGTTGGCGATGACAATTATTATATTATTTTCACAAGCGGCACAACCGGCAAACCTAAA
GGTGTTCAGATCAGTCATGATAACTTGTTGAGTTACGTGAACTGGAACATTTCCGATTTTGGTCTCAAGGAAGGCGTTGT
GGCCATGTCACAGCCACCCTATTCTTTTGACTTGAGTGTCATGGATTTGTACCCGACGTTGGTTTTGGGCGGTACGCTTA
AGGCATTGCCAAAGGAAGTAACGGACAATTTCAAAACGTTGTTCGCAACCTTACCTAAGCTAGGTTTGAATGAGTGGGTA
TCAACCCCGTCGTTTGCCGAAATTGCCTTGCTTGATCCTAATTTCAATCAAGATAATTACCCTGATTTGACACATTTCCT
GTTCTGTGGTGAAGAATTGGTCAATAAAACGGCGCAGGAGTTGATCACCCGTTTTCCAAAGGCAACCGTGTATAACACAT
ATGGCCCAACCGAAACGACTGTGGCGGTCACAGGAATGGCAATTACGCAGGACATTGTGGATCAATATCCGCGTTTGCCA
ATTGGTTTTGCTAAACCGGATACGGAAATTTTCGTTGTCGATGAGCAAGGCAATCAAGTGTCAGCGGGTACCGAAGGCGA
ATTGATGATTGTTGGACCAAGTGTTTCAAAGGGGTATCTTAACAATCCTGAGAAAACGGCCAAAGCTTTCTTCAATGTTG
GCAGTCAACGCGGCTATCGGTCAGGCGATTTAGCCACGATGACTGAGGATGGCATGATTTTCTATCGTGGCCGAACTGAC
TTTCAGGTTAAGCTGCATGGCTATCGAATCGAGCTTGAAGATGTTGATCATAACTTAAATCAGGTTTCCTACATCAAACA
AGCTTCAACGGTACCGCGCTACAACAAGGATCATAAGGTTGCTCAACTGATTGCTTTTGCAGTGGCGAAGCCCAATGACT
TCGAAAGCGATATGAAGCTCACTCAGGCAGTGAAAGCTGAGCTAGGCAAAATGGTGATGGAATATATGATCCCGCAGCGC
ATTATCTATCGTGACAAATTACCGCTGACAGCCAACGGCAAAGTCGATCGGAAAGCGCTGATTGCAGAGGTAAATCATTA
A

Upstream 100 bases:

>100_bases
AATAACAGTAAATTCATTTATAACGAGTTCTAAAAGCGTGAATTGGCGCGACTAGAAACCGGAGCGCCAGTGAACGCGTC
TAAAGAGGAGGAGAGCCAAT

Downstream 100 bases:

>100_bases
TGCTGAACTTACAACCATATGAGAATCCGCAATACTTTGTTTATCTCATCATTGCTTTACTGCCAGTTATCATTGGCATG
TTCAAGGGTTTCCGGATGCA

Product: D-alanine-activating enzyme

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MIDNVITAIDRVAAEHPTRVAYDYEGTQYTYAQLKEGSDRLAGFFAETLPEHEPIIVYGGQTFDMVEVFLGLSKSGHAYI
PIDTHSPNERITQVQDVAHTPAIIEVAPLPIAVPDVQIIRAPALHEAEKTHAPISSLQHAVVGDDNYYIIFTSGTTGKPK
GVQISHDNLLSYVNWNISDFGLKEGVVAMSQPPYSFDLSVMDLYPTLVLGGTLKALPKEVTDNFKTLFATLPKLGLNEWV
STPSFAEIALLDPNFNQDNYPDLTHFLFCGEELVNKTAQELITRFPKATVYNTYGPTETTVAVTGMAITQDIVDQYPRLP
IGFAKPDTEIFVVDEQGNQVSAGTEGELMIVGPSVSKGYLNNPEKTAKAFFNVGSQRGYRSGDLATMTEDGMIFYRGRTD
FQVKLHGYRIELEDVDHNLNQVSYIKQASTVPRYNKDHKVAQLIAFAVAKPNDFESDMKLTQAVKAELGKMVMEYMIPQR
IIYRDKLPLTANGKVDRKALIAEVNH

Sequences:

>Translated_506_residues
MIDNVITAIDRVAAEHPTRVAYDYEGTQYTYAQLKEGSDRLAGFFAETLPEHEPIIVYGGQTFDMVEVFLGLSKSGHAYI
PIDTHSPNERITQVQDVAHTPAIIEVAPLPIAVPDVQIIRAPALHEAEKTHAPISSLQHAVVGDDNYYIIFTSGTTGKPK
GVQISHDNLLSYVNWNISDFGLKEGVVAMSQPPYSFDLSVMDLYPTLVLGGTLKALPKEVTDNFKTLFATLPKLGLNEWV
STPSFAEIALLDPNFNQDNYPDLTHFLFCGEELVNKTAQELITRFPKATVYNTYGPTETTVAVTGMAITQDIVDQYPRLP
IGFAKPDTEIFVVDEQGNQVSAGTEGELMIVGPSVSKGYLNNPEKTAKAFFNVGSQRGYRSGDLATMTEDGMIFYRGRTD
FQVKLHGYRIELEDVDHNLNQVSYIKQASTVPRYNKDHKVAQLIAFAVAKPNDFESDMKLTQAVKAELGKMVMEYMIPQR
IIYRDKLPLTANGKVDRKALIAEVNH
>Mature_506_residues
MIDNVITAIDRVAAEHPTRVAYDYEGTQYTYAQLKEGSDRLAGFFAETLPEHEPIIVYGGQTFDMVEVFLGLSKSGHAYI
PIDTHSPNERITQVQDVAHTPAIIEVAPLPIAVPDVQIIRAPALHEAEKTHAPISSLQHAVVGDDNYYIIFTSGTTGKPK
GVQISHDNLLSYVNWNISDFGLKEGVVAMSQPPYSFDLSVMDLYPTLVLGGTLKALPKEVTDNFKTLFATLPKLGLNEWV
STPSFAEIALLDPNFNQDNYPDLTHFLFCGEELVNKTAQELITRFPKATVYNTYGPTETTVAVTGMAITQDIVDQYPRLP
IGFAKPDTEIFVVDEQGNQVSAGTEGELMIVGPSVSKGYLNNPEKTAKAFFNVGSQRGYRSGDLATMTEDGMIFYRGRTD
FQVKLHGYRIELEDVDHNLNQVSYIKQASTVPRYNKDHKVAQLIAFAVAKPNDFESDMKLTQAVKAELGKMVMEYMIPQR
IIYRDKLPLTANGKVDRKALIAEVNH

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily

Homologues:

Organism=Homo sapiens, GI115511026, Length=516, Percent_Identity=24.8062015503876, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI187761345, Length=393, Percent_Identity=26.4631043256997, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI187761343, Length=393, Percent_Identity=26.4631043256997, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156151445, Length=544, Percent_Identity=24.2647058823529, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI38505220, Length=374, Percent_Identity=26.2032085561497, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI45580730, Length=385, Percent_Identity=24.6753246753247, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI58082049, Length=404, Percent_Identity=24.7524752475248, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI42544132, Length=405, Percent_Identity=24.1975308641975, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI157311624, Length=391, Percent_Identity=25.3196930946292, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI157311622, Length=391, Percent_Identity=25.3196930946292, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI122937307, Length=395, Percent_Identity=25.8227848101266, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI28416953, Length=381, Percent_Identity=24.9343832020997, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786801, Length=456, Percent_Identity=28.7280701754386, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI145693145, Length=370, Percent_Identity=28.6486486486486, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786810, Length=374, Percent_Identity=24.5989304812834, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788107, Length=401, Percent_Identity=25.4364089775561, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17558820, Length=505, Percent_Identity=21.5841584158416, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=380, Percent_Identity=24.2105263157895, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=380, Percent_Identity=24.2105263157895, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=380, Percent_Identity=24.2105263157895, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17560308, Length=380, Percent_Identity=25, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=493, Percent_Identity=21.501014198783, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17550940, Length=358, Percent_Identity=24.0223463687151, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17556356, Length=491, Percent_Identity=25.050916496945, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17557194, Length=424, Percent_Identity=24.2924528301887, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17531443, Length=370, Percent_Identity=22.4324324324324, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538037, Length=409, Percent_Identity=24.6943765281174, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71985884, Length=384, Percent_Identity=23.1770833333333, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=558, Percent_Identity=24.910394265233, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319699, Length=370, Percent_Identity=25.9459459459459, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648676, Length=546, Percent_Identity=27.4725274725275, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI18859661, Length=381, Percent_Identity=24.9343832020997, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355181, Length=367, Percent_Identity=23.7057220708447, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281364798, Length=550, Percent_Identity=23.2727272727273, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583465, Length=550, Percent_Identity=23.2727272727273, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583463, Length=550, Percent_Identity=23.2727272727273, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DLTA_LACC3 (Q03AZ2)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806072.1
- ProteinModelPortal:   Q03AZ2
- SMR:   Q03AZ2
- STRING:   Q03AZ2
- GeneID:   4419382
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_0794
- eggNOG:   COG1020
- HOGENOM:   HBG320748
- OMA:   PNERITQ
- ProtClustDB:   CLSK2317801
- BioCyc:   LCAS321967:LSEI_0794-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00593
- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072
- PANTHER:   PTHR11968:SF34
- TIGRFAMs:   TIGR01733
- TIGRFAMs:   TIGR01734

Pfam domain/function: PF00501 AMP-binding

EC number: =6.1.1.13

Molecular weight: Translated: 56144; Mature: 56144

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDNVITAIDRVAAEHPTRVAYDYEGTQYTYAQLKEGSDRLAGFFAETLPEHEPIIVYGG
CCCHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHCCCHHHHHHHHHHCCCCCCEEEECC
QTFDMVEVFLGLSKSGHAYIPIDTHSPNERITQVQDVAHTPAIIEVAPLPIAVPDVQIIR
CCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCEECCCHHEEE
APALHEAEKTHAPISSLQHAVVGDDNYYIIFTSGTTGKPKGVQISHDNLLSYVNWNISDF
CCCHHHHHHHCCCHHHHCHHEECCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCHHC
GLKEGVVAMSQPPYSFDLSVMDLYPTLVLGGTLKALPKEVTDNFKTLFATLPKLGLNEWV
CCCCCEEEECCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
STPSFAEIALLDPNFNQDNYPDLTHFLFCGEELVNKTAQELITRFPKATVYNTYGPTETT
CCCCCEEEEEECCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHCCCCEEEECCCCCCCE
VAVTGMAITQDIVDQYPRLPIGFAKPDTEIFVVDEQGNQVSAGTEGELMIVGPSVSKGYL
EEEECHHHHHHHHHHCCCCCEECCCCCCEEEEEECCCCEECCCCCCCEEEECCCCCCCCC
NNPEKTAKAFFNVGSQRGYRSGDLATMTEDGMIFYRGRTDFQVKLHGYRIELEDVDHNLN
CCHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEECCCEEEEEEEEEEEEEECCCCCHH
QVSYIKQASTVPRYNKDHKVAQLIAFAVAKPNDFESDMKLTQAVKAELGKMVMEYMIPQR
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
IIYRDKLPLTANGKVDRKALIAEVNH
HHHHCCCCCCCCCCCCCEEHEEECCC
>Mature Secondary Structure
MIDNVITAIDRVAAEHPTRVAYDYEGTQYTYAQLKEGSDRLAGFFAETLPEHEPIIVYGG
CCCHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHCCCHHHHHHHHHHCCCCCCEEEECC
QTFDMVEVFLGLSKSGHAYIPIDTHSPNERITQVQDVAHTPAIIEVAPLPIAVPDVQIIR
CCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCEECCCHHEEE
APALHEAEKTHAPISSLQHAVVGDDNYYIIFTSGTTGKPKGVQISHDNLLSYVNWNISDF
CCCHHHHHHHCCCHHHHCHHEECCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCHHC
GLKEGVVAMSQPPYSFDLSVMDLYPTLVLGGTLKALPKEVTDNFKTLFATLPKLGLNEWV
CCCCCEEEECCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
STPSFAEIALLDPNFNQDNYPDLTHFLFCGEELVNKTAQELITRFPKATVYNTYGPTETT
CCCCCEEEEEECCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHCCCCEEEECCCCCCCE
VAVTGMAITQDIVDQYPRLPIGFAKPDTEIFVVDEQGNQVSAGTEGELMIVGPSVSKGYL
EEEECHHHHHHHHHHCCCCCEECCCCCCEEEEEECCCCEECCCCCCCEEEECCCCCCCCC
NNPEKTAKAFFNVGSQRGYRSGDLATMTEDGMIFYRGRTDFQVKLHGYRIELEDVDHNLN
CCHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEECCCEEEEEEEEEEEEEECCCCCHH
QVSYIKQASTVPRYNKDHKVAQLIAFAVAKPNDFESDMKLTQAVKAELGKMVMEYMIPQR
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
IIYRDKLPLTANGKVDRKALIAEVNH
HHHHCCCCCCCCCCCCCEEHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA