Click here to switch to the map view.

The map label for this gene is gph [C]

Identifier: 116494298

GI number: 116494298

Start: 751548

End: 752216

Strand: Direct

Name: gph [C]

Synonym: LSEI_0754

Alternate gene names: 116494298

Gene position: 751548-752216 (Clockwise)

Preceding gene: 116494297

Following gene: 116494300

Centisome position: 25.96

GC content: 45.59

Gene sequence:

>669_bases
ATGGCTAATTTGTTTTTTGACTTTGATGGCACCGTTGCTGATTCGGAAGTCGGTATCGTTGCAGGATTAAAATATATGGT
TCAGGATCGCGGATTGCGGCCGCTGGACAATTCGGCCTACACGCAATTTATCGGACCAGCGCTGATTGATATGCTTCCCA
AGGTTTGGCCAGAACTTGATGACATTGAAGTTAAGCGGGCCATTGATGCTTTCCATCATTATTACGAAGAGGAAGGCCTT
TATCAGGTTGAATTGTATCCTAATTTTCTGGACACGATGGCAAAGCTCAAGCAACAAGACAACCAACTTTACATTGCCTC
GGCTAAGCCAGAAACAATGCTGCATCGCCTTGTAAAGCACTTTTCGTTGGACCAATATTTTGCTGGTGCGTACGGTGCAA
GTGACGATGAGGAAACCCGGGTCACGAAAACCGATATTTTGACCTATGCGCTAAAAGACAGTCAAGTTGCGCTCGATCAA
AGTGTCATGATTGGTGATCGGGCCAATGATATGATTGGTGGCAAGGCCAATCATGTTCAATTGCTGGGTGTGACGTACGG
CTTTGGTTCTGCTAAAGAACTAAAAGAAGCCGGTGCCAAAGTCTTAGTTGATCAACCTGCAGATATTCCTGCAGGACTGG
CGAAGCTAGCAAAGATCAACGCAAAATAG

Upstream 100 bases:

>100_bases
TTAACGCGACATAAAGCCGAGCGTGCGTGCGAGTTCTTAAAAATGTGTTGACTGGGCAATCATTGCGGGACTGGCGGCCG
CGTTTATGAGGGGGATTCAA

Downstream 100 bases:

>100_bases
TGCCCTAATCAAGCTTGATTAAGGAACCAGACAAAAAAGACGTGCCTGTAAATGGCACGTCTTTTTTGTCTGGCACGAGA
TACCGAATTATTGATCGTCC

Product: phosphatase

Products: NA

Alternate protein names: Nucleoside 5'-monophosphate phosphohydrolase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MANLFFDFDGTVADSEVGIVAGLKYMVQDRGLRPLDNSAYTQFIGPALIDMLPKVWPELDDIEVKRAIDAFHHYYEEEGL
YQVELYPNFLDTMAKLKQQDNQLYIASAKPETMLHRLVKHFSLDQYFAGAYGASDDEETRVTKTDILTYALKDSQVALDQ
SVMIGDRANDMIGGKANHVQLLGVTYGFGSAKELKEAGAKVLVDQPADIPAGLAKLAKINAK

Sequences:

>Translated_222_residues
MANLFFDFDGTVADSEVGIVAGLKYMVQDRGLRPLDNSAYTQFIGPALIDMLPKVWPELDDIEVKRAIDAFHHYYEEEGL
YQVELYPNFLDTMAKLKQQDNQLYIASAKPETMLHRLVKHFSLDQYFAGAYGASDDEETRVTKTDILTYALKDSQVALDQ
SVMIGDRANDMIGGKANHVQLLGVTYGFGSAKELKEAGAKVLVDQPADIPAGLAKLAKINAK
>Mature_221_residues
ANLFFDFDGTVADSEVGIVAGLKYMVQDRGLRPLDNSAYTQFIGPALIDMLPKVWPELDDIEVKRAIDAFHHYYEEEGLY
QVELYPNFLDTMAKLKQQDNQLYIASAKPETMLHRLVKHFSLDQYFAGAYGASDDEETRVTKTDILTYALKDSQVALDQS
VMIGDRANDMIGGKANHVQLLGVTYGFGSAKELKEAGAKVLVDQPADIPAGLAKLAKINAK

Specific function: Specifically dephosphorylates nucleoside 5'- monophosphates to nucleosides and inorganic phosphate. Displays high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP [H]

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.5 [H]

Molecular weight: Translated: 24611; Mature: 24480

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLFFDFDGTVADSEVGIVAGLKYMVQDRGLRPLDNSAYTQFIGPALIDMLPKVWPELD
CCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
DIEVKRAIDAFHHYYEEEGLYQVELYPNFLDTMAKLKQQDNQLYIASAKPETMLHRLVKH
HHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
FSLDQYFAGAYGASDDEETRVTKTDILTYALKDSQVALDQSVMIGDRANDMIGGKANHVQ
CCHHHHHHCCCCCCCCCCCHHHHHHHEEEEECCCCHHHCCEEEECCCCCCCCCCCCCEEE
LLGVTYGFGSAKELKEAGAKVLVDQPADIPAGLAKLAKINAK
EEEEEECCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
ANLFFDFDGTVADSEVGIVAGLKYMVQDRGLRPLDNSAYTQFIGPALIDMLPKVWPELD
CCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
DIEVKRAIDAFHHYYEEEGLYQVELYPNFLDTMAKLKQQDNQLYIASAKPETMLHRLVKH
HHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
FSLDQYFAGAYGASDDEETRVTKTDILTYALKDSQVALDQSVMIGDRANDMIGGKANHVQ
CCHHHHHHCCCCCCCCCCCHHHHHHHEEEEECCCCHHHCCEEEECCCCCCCCCCCCCEEE
LLGVTYGFGSAKELKEAGAKVLVDQPADIPAGLAKLAKINAK
EEEEEECCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]