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The map label for this gene is pip [H]

Identifier: 116494294

GI number: 116494294

Start: 748135

End: 749058

Strand: Direct

Name: pip [H]

Synonym: LSEI_0750

Alternate gene names: 116494294

Gene position: 748135-749058 (Clockwise)

Preceding gene: 116494290

Following gene: 116494295

Centisome position: 25.84

GC content: 47.84

Gene sequence:

>924_bases
ATGCCAAAACTTAATCCAGACGGGACGCAATTCATCACGTTATCGAGTGGGTACCATTTGTGGACACAGACGCAAGGGAA
AGGTGATATCCATCTCATGACCTTGCATGGTGGCCCAGGCGGCACCAATGAAGTCTTTGAAAATTTTGCTGAGCGGCTAG
CGCCTTATGGTGTGCGCGTGACCCGTTATGATCAGTTGGGGTCATTTTACTCCGACCAGCCAGATTTCTCCGATCCGGCA
AATCGTCAGCAGTTTCTGAACATTGATTACTATCTGAGCGAAGTGGAGCAGGTTCGACAGCAGCTTGGGATTGACCACTT
TTATCTGCTTGGTCAATCGTGGGGCGGTGTGCTGGCAATTGAATATGCATTGAAATATCCAGAGCATCTTAACGGAGTCA
TTCTGAGTTCGATGATTGACAATCTTGACGAATATATTGTGAACATCAATCGGATTCGGGAAACTATGTTTTCAAAAGAA
GATGTCGCTTACATGCAGCAAATTGAACAGCAGCATGCGTTCGATGATGCAAAATATCAGGCGCTTGTAAGTGAGCTAGG
CGAACACTACTTGCATCATGCAAAAGATCCGCAGCCGCGTCACTTAATCAGTACGCTGGCCACGCCAGTTTACAATTATT
TTCAAGGCGACAATGAATTTGTGATGGTGGGTGCGCTTAAAGATTGGGATCGGCGTGCAGATATCCACCGTATCGCCGTA
CCCACCTACCTGACGTTCGGCGGTCATGAAACGATGCCGTTGGCAGCCGCGGAACGCATGGCGAAGACAATCCCAGACGC
TACCTTACATGTCACGCCGAATGCTGGTCATGGACAAATGCTGGATAACCCCACTGACTATTTCAGTCATTTAGGTGATT
GGCTGGTCAACACCGACACGAAGACGGCTTTTCATTCTAAATAA

Upstream 100 bases:

>100_bases
AACTTTGAAGAGTCTTATAAGATTGCGAAGTGGCTTAATGTTGTTCATCAACCACGAAACTCGCATAATGGAAGACAAAC
GACAAGAAAGAAGCGGTTGT

Downstream 100 bases:

>100_bases
CGTTATAATAAGAATGGTAAGGTAAGTTTTTCAAAATATGGAGGTGCTTGCATGTCTGAATATGATGAATTAAAAACAAG
CTTGTTCGAACCTGTACGAG

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP; Tricorn protease-interacting factor F1 [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MPKLNPDGTQFITLSSGYHLWTQTQGKGDIHLMTLHGGPGGTNEVFENFAERLAPYGVRVTRYDQLGSFYSDQPDFSDPA
NRQQFLNIDYYLSEVEQVRQQLGIDHFYLLGQSWGGVLAIEYALKYPEHLNGVILSSMIDNLDEYIVNINRIRETMFSKE
DVAYMQQIEQQHAFDDAKYQALVSELGEHYLHHAKDPQPRHLISTLATPVYNYFQGDNEFVMVGALKDWDRRADIHRIAV
PTYLTFGGHETMPLAAAERMAKTIPDATLHVTPNAGHGQMLDNPTDYFSHLGDWLVNTDTKTAFHSK

Sequences:

>Translated_307_residues
MPKLNPDGTQFITLSSGYHLWTQTQGKGDIHLMTLHGGPGGTNEVFENFAERLAPYGVRVTRYDQLGSFYSDQPDFSDPA
NRQQFLNIDYYLSEVEQVRQQLGIDHFYLLGQSWGGVLAIEYALKYPEHLNGVILSSMIDNLDEYIVNINRIRETMFSKE
DVAYMQQIEQQHAFDDAKYQALVSELGEHYLHHAKDPQPRHLISTLATPVYNYFQGDNEFVMVGALKDWDRRADIHRIAV
PTYLTFGGHETMPLAAAERMAKTIPDATLHVTPNAGHGQMLDNPTDYFSHLGDWLVNTDTKTAFHSK
>Mature_306_residues
PKLNPDGTQFITLSSGYHLWTQTQGKGDIHLMTLHGGPGGTNEVFENFAERLAPYGVRVTRYDQLGSFYSDQPDFSDPAN
RQQFLNIDYYLSEVEQVRQQLGIDHFYLLGQSWGGVLAIEYALKYPEHLNGVILSSMIDNLDEYIVNINRIRETMFSKED
VAYMQQIEQQHAFDDAKYQALVSELGEHYLHHAKDPQPRHLISTLATPVYNYFQGDNEFVMVGALKDWDRRADIHRIAVP
TYLTFGGHETMPLAAAERMAKTIPDATLHVTPNAGHGQMLDNPTDYFSHLGDWLVNTDTKTAFHSK

Specific function: Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus. In conjunction with the three factors F1, F2 and F3, Tricorn degrades oligopeptides in a sequential manner, yielding

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 34941; Mature: 34810

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLNPDGTQFITLSSGYHLWTQTQGKGDIHLMTLHGGPGGTNEVFENFAERLAPYGVRV
CCCCCCCCCEEEEEECCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEE
TRYDQLGSFYSDQPDFSDPANRQQFLNIDYYLSEVEQVRQQLGIDHFYLLGQSWGGVLAI
EEHHHHCCCCCCCCCCCCCCCHHHEECHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
EYALKYPEHLNGVILSSMIDNLDEYIVNINRIRETMFSKEDVAYMQQIEQQHAFDDAKYQ
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHH
ALVSELGEHYLHHAKDPQPRHLISTLATPVYNYFQGDNEFVMVGALKDWDRRADIHRIAV
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHCCCEEEEE
PTYLTFGGHETMPLAAAERMAKTIPDATLHVTPNAGHGQMLDNPTDYFSHLGDWLVNTDT
CEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCC
KTAFHSK
CHHCCCC
>Mature Secondary Structure 
PKLNPDGTQFITLSSGYHLWTQTQGKGDIHLMTLHGGPGGTNEVFENFAERLAPYGVRV
CCCCCCCCEEEEEECCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEE
TRYDQLGSFYSDQPDFSDPANRQQFLNIDYYLSEVEQVRQQLGIDHFYLLGQSWGGVLAI
EEHHHHCCCCCCCCCCCCCCCHHHEECHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
EYALKYPEHLNGVILSSMIDNLDEYIVNINRIRETMFSKEDVAYMQQIEQQHAFDDAKYQ
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHH
ALVSELGEHYLHHAKDPQPRHLISTLATPVYNYFQGDNEFVMVGALKDWDRRADIHRIAV
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHCCCEEEEE
PTYLTFGGHETMPLAAAERMAKTIPDATLHVTPNAGHGQMLDNPTDYFSHLGDWLVNTDT
CEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCC
KTAFHSK
CHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]