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The map label for this gene is mutS2 [H]

Identifier: 116494207

GI number: 116494207

Start: 658926

End: 660602

Strand: Direct

Name: mutS2 [H]

Synonym: LSEI_0658

Alternate gene names: 116494207

Gene position: 658926-660602 (Clockwise)

Preceding gene: 116494206

Following gene: 116494208

Centisome position: 22.76

GC content: 48.18

Gene sequence:

>1677_bases
ATGTCACAACCCATTACGATTCTTCTCAGTGTCACCGGCTTTATTGTTGCGATGATTGTCCTCAATGGTTTGTTAACCTG
GCAGCGACAGCAAAAGCTCAAGCGCCAATTGCTAGCTGACTGGGGCACTTTTGCTGAAAAACGGCCAAAAGGTGAGCGCT
ATTTAAAAGCCGCCTATCTTGATCATGAAGCCCAAGTTAATCACGATTGCCAAGTTGACGACCTGACTTGGCAGGATCTT
GATATGTTAGACGTGTTCGAACAGCTGAACGTCACCCAAAGTAGTGTTGGCGCTGAAGGGGTCTATGCACAATTGCGGGC
TTATGATTTAGGCAAACCAGCTGTTGACGAGGCGTTGATTGCCTTTTTTCAAGATCATCCTGACAGCCGATTGAAAGTGC
AAATGGCGTTTGCCGGACTTGGCATCGAGCCGGCGAACAATAGCCAACTTTATCTACGAACAACCACCAAAAAAGCCTTG
CCGAATGCATGGCGATTCAAAGTAATGGGCGGTTTTCCATTTATCGGTGTCTTGTTGACGCTATTGTGGCCGGCAATTGG
GGTGACCTTGATGGTGGTCAGTTTGATGGTCAACGTGTTCTACTACATTTTGAAACGTGAAGGCCTTGATGCCGAAATTA
CGTCTATGGGTTACCTTGTCCGGACGATTATCACAGCAGAACGTCTCGCCAAAATTAGCCAACCGACTCAAGTAGCATTG
CGACAAGCAGTTAAACCAATGCGCGGCATCACGCGATTTGCGTTTGTCTTCCGGACCAAGACCGGCAGCATGGGCGACAT
TTTAACTGAGTATCTTAGCATCATGTTCATGCTGAGCTTTATTGCCTACAACACAGTGCTCGATCGCTTAAGCAGCCACC
ATGCTGAGGCACTAGCCCTGTGGCAATGGCTGGGCGATTTAGAGTTGGCCATTGCCATTGCTAATTTTCGCGCGACGGAA
GCGACTACAACGCAGCCAGTCTTTGCCAAAGGCGGCATGACCGCTACTGACTTAGCCCATCCATTGTTGAAACATCCCGT
TGCCAACTCAGTTGACTGGCAGAAAAATGCGTTGATCACCGGTGCCAATGCTTCCGGTAAGTCGACCTACGTCAAAAGTA
TTGCGATCAATGCCATTTTGGCCCAAACGATCAATACCGTGACAGCGACAAGTTTCACGATGGAGCCGGGAGAGGTCATC
ACGGCTATGGCGGTGCGTGATGATCTGAGTGAAGGCGATAGCTATTTTGTTGCAGAAATTAAAGCAATTCGGCGGCTGCT
CAATGCTGTTGCCAAAAAGAAACGCGTCTATGGTTTTATCGACGAAATTCTAAAAGGGACGAATACCGTCGAACGAATTG
CCGCTTCAGCGAGTGTCATTAATTGGCTAAAGCAATATCCGAGTTTGGTTGTGGTCGCGACACATGATAATGAATTGACG
GACATTATGGGCGATCAATGCGTCAACTGGCATTTTCAAGAGAAAGTGACGAAGGAGGATGGCGTTGTCTTTGACTATTT
GCTCTATCAAGGCCCGGCCACTTCGCATAATGCCATAGCACTGTTGGCAACCATGGACTATCCAACGTCCTTAATTCACG
ATGCGCGGCAGTTGGCTGCGGATTTTGAACGTAGCAAAGCATGGCCTAAGTTTGTTAAAGGAGGGATTCAAGCGTGA

Upstream 100 bases:

>100_bases
GCATAAGTAACCGACAAGATAAGTGTGTGTGTGACCCGCGCAAGTTGTTATTGAAAGTCTCACCAATCTGGTCACATCAG
CTAAGAAAGCAGTGATCAAT

Downstream 100 bases:

>100_bases
CAGATGCAGACAAAATATTTGAGGCTATTCGTCAGGATCCCGATAACGCTGACTTTACCGCCCAAGGATGGGATCCGCTA
TATCATATTGAACCTGAAGC

Product: mismatch repair ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MSQPITILLSVTGFIVAMIVLNGLLTWQRQQKLKRQLLADWGTFAEKRPKGERYLKAAYLDHEAQVNHDCQVDDLTWQDL
DMLDVFEQLNVTQSSVGAEGVYAQLRAYDLGKPAVDEALIAFFQDHPDSRLKVQMAFAGLGIEPANNSQLYLRTTTKKAL
PNAWRFKVMGGFPFIGVLLTLLWPAIGVTLMVVSLMVNVFYYILKREGLDAEITSMGYLVRTIITAERLAKISQPTQVAL
RQAVKPMRGITRFAFVFRTKTGSMGDILTEYLSIMFMLSFIAYNTVLDRLSSHHAEALALWQWLGDLELAIAIANFRATE
ATTTQPVFAKGGMTATDLAHPLLKHPVANSVDWQKNALITGANASGKSTYVKSIAINAILAQTINTVTATSFTMEPGEVI
TAMAVRDDLSEGDSYFVAEIKAIRRLLNAVAKKKRVYGFIDEILKGTNTVERIAASASVINWLKQYPSLVVVATHDNELT
DIMGDQCVNWHFQEKVTKEDGVVFDYLLYQGPATSHNAIALLATMDYPTSLIHDARQLAADFERSKAWPKFVKGGIQA

Sequences:

>Translated_558_residues
MSQPITILLSVTGFIVAMIVLNGLLTWQRQQKLKRQLLADWGTFAEKRPKGERYLKAAYLDHEAQVNHDCQVDDLTWQDL
DMLDVFEQLNVTQSSVGAEGVYAQLRAYDLGKPAVDEALIAFFQDHPDSRLKVQMAFAGLGIEPANNSQLYLRTTTKKAL
PNAWRFKVMGGFPFIGVLLTLLWPAIGVTLMVVSLMVNVFYYILKREGLDAEITSMGYLVRTIITAERLAKISQPTQVAL
RQAVKPMRGITRFAFVFRTKTGSMGDILTEYLSIMFMLSFIAYNTVLDRLSSHHAEALALWQWLGDLELAIAIANFRATE
ATTTQPVFAKGGMTATDLAHPLLKHPVANSVDWQKNALITGANASGKSTYVKSIAINAILAQTINTVTATSFTMEPGEVI
TAMAVRDDLSEGDSYFVAEIKAIRRLLNAVAKKKRVYGFIDEILKGTNTVERIAASASVINWLKQYPSLVVVATHDNELT
DIMGDQCVNWHFQEKVTKEDGVVFDYLLYQGPATSHNAIALLATMDYPTSLIHDARQLAADFERSKAWPKFVKGGIQA
>Mature_557_residues
SQPITILLSVTGFIVAMIVLNGLLTWQRQQKLKRQLLADWGTFAEKRPKGERYLKAAYLDHEAQVNHDCQVDDLTWQDLD
MLDVFEQLNVTQSSVGAEGVYAQLRAYDLGKPAVDEALIAFFQDHPDSRLKVQMAFAGLGIEPANNSQLYLRTTTKKALP
NAWRFKVMGGFPFIGVLLTLLWPAIGVTLMVVSLMVNVFYYILKREGLDAEITSMGYLVRTIITAERLAKISQPTQVALR
QAVKPMRGITRFAFVFRTKTGSMGDILTEYLSIMFMLSFIAYNTVLDRLSSHHAEALALWQWLGDLELAIAIANFRATEA
TTTQPVFAKGGMTATDLAHPLLKHPVANSVDWQKNALITGANASGKSTYVKSIAINAILAQTINTVTATSFTMEPGEVIT
AMAVRDDLSEGDSYFVAEIKAIRRLLNAVAKKKRVYGFIDEILKGTNTVERIAASASVINWLKQYPSLVVVATHDNELTD
IMGDQCVNWHFQEKVTKEDGVVFDYLLYQGPATSHNAIALLATMDYPTSLIHDARQLAADFERSKAWPKFVKGGIQA

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=223, Percent_Identity=29.5964125560538, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1789089, Length=274, Percent_Identity=27.7372262773723, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17508445, Length=302, Percent_Identity=27.8145695364238, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=309, Percent_Identity=27.1844660194175, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321109, Length=261, Percent_Identity=23.7547892720307, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 61980; Mature: 61849

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPITILLSVTGFIVAMIVLNGLLTWQRQQKLKRQLLADWGTFAEKRPKGERYLKAAYL
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DHEAQVNHDCQVDDLTWQDLDMLDVFEQLNVTQSSVGAEGVYAQLRAYDLGKPAVDEALI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHCCCCHHHHHHHHHCCCCCHHHHHHH
AFFQDHPDSRLKVQMAFAGLGIEPANNSQLYLRTTTKKALPNAWRFKVMGGFPFIGVLLT
HHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEEECCHHHCCCCEEEEEECCCCHHHHHHH
LLWPAIGVTLMVVSLMVNVFYYILKREGLDAEITSMGYLVRTIITAERLAKISQPTQVAL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RQAVKPMRGITRFAFVFRTKTGSMGDILTEYLSIMFMLSFIAYNTVLDRLSSHHAEALAL
HHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WQWLGDLELAIAIANFRATEATTTQPVFAKGGMTATDLAHPLLKHPVANSVDWQKNALIT
HHHHCCHHEEEEEECCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEE
GANASGKSTYVKSIAINAILAQTINTVTATSFTMEPGEVITAMAVRDDLSEGDSYFVAEI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCCCCHHHHHH
KAIRRLLNAVAKKKRVYGFIDEILKGTNTVERIAASASVINWLKQYPSLVVVATHDNELT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHH
DIMGDQCVNWHFQEKVTKEDGVVFDYLLYQGPATSHNAIALLATMDYPTSLIHDARQLAA
HHHHHHHCCCHHHHHCCCCCCCEEEHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
DFERSKAWPKFVKGGIQA
HHHHHCCCHHHHCCCCCC
>Mature Secondary Structure 
SQPITILLSVTGFIVAMIVLNGLLTWQRQQKLKRQLLADWGTFAEKRPKGERYLKAAYL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DHEAQVNHDCQVDDLTWQDLDMLDVFEQLNVTQSSVGAEGVYAQLRAYDLGKPAVDEALI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHCCCCHHHHHHHHHCCCCCHHHHHHH
AFFQDHPDSRLKVQMAFAGLGIEPANNSQLYLRTTTKKALPNAWRFKVMGGFPFIGVLLT
HHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEEECCHHHCCCCEEEEEECCCCHHHHHHH
LLWPAIGVTLMVVSLMVNVFYYILKREGLDAEITSMGYLVRTIITAERLAKISQPTQVAL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RQAVKPMRGITRFAFVFRTKTGSMGDILTEYLSIMFMLSFIAYNTVLDRLSSHHAEALAL
HHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WQWLGDLELAIAIANFRATEATTTQPVFAKGGMTATDLAHPLLKHPVANSVDWQKNALIT
HHHHCCHHEEEEEECCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEE
GANASGKSTYVKSIAINAILAQTINTVTATSFTMEPGEVITAMAVRDDLSEGDSYFVAEI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCCCCHHHHHH
KAIRRLLNAVAKKKRVYGFIDEILKGTNTVERIAASASVINWLKQYPSLVVVATHDNELT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHH
DIMGDQCVNWHFQEKVTKEDGVVFDYLLYQGPATSHNAIALLATMDYPTSLIHDARQLAA
HHHHHHHCCCHHHHHCCCCCCCEEEHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
DFERSKAWPKFVKGGIQA
HHHHHCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA