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The map label for this gene is htrA [H]

Identifier: 116493520

GI number: 116493520

Start: 1770231

End: 1771481

Strand: Reverse

Name: htrA [H]

Synonym: PEPE_1792

Alternate gene names: 116493520

Gene position: 1771481-1770231 (Counterclockwise)

Preceding gene: 116493521

Following gene: 116493518

Centisome position: 96.68

GC content: 39.73

Gene sequence:

>1251_bases
ATGAAAACAAACAAATTAGTCATTGTTGCAGCCATTGCGGGCCTACTGGGTGGGGGTGTTGCTTATGGTGGGGCGAGCTT
CATTCATAACCAGATGGAATCATCTAGTACAGCAGTACCAACGGGCTCAAATACCACAGGAACAACCAAGACTAGTAATG
TTAAAGTTAACGTAAGTAGTCAATCATCCAAAGCATTCTCTACAATTAAGGATTCAGTGGTTTCAGTGATTAACCTACAA
AAGGCTAATACTAATGATTCTGACAGTATCATTAGCTCAATTTTTGGAAACGAATCGAGTTCTTCTAGCAAATCATCAAG
TAGCTCTTCAGAATTAGAGACCGCCTCAGAAGGATCTGGAGTTATCTATAAAAAGAGTGGTGACACAGCCTATATTGTAA
CGAATAACCATGTAGTAAGTGGCTCAAGTTCACTTGAGATTATTATGAGCAATGGTAAAAAACTTCCTGCTAAGATTGTG
GGAACAGATAGTGTAACGGATTTGGCCGTGTTGAAGATTAATTCATCAGCAGTTACCACCGTTGCTAGCTTTGGTAATTC
CGATAACATTAAAGTTGGTGAAACAGCCTTGGCAATTGGATCACCATTAGGATCAGAATATGCTACCTCACTAACCCAAG
GAATTATTTCGGCTAAGAAACGAACGGTGGAAACTACCACTGAAAATGGACAGAATAATGGAGAAGCAACTGTTATTCAG
ACGGATGCAGCCATCAATGCCGGAAATTCTGGCGGCCCACTAATTAACTTAGCTGGCCAAGTAATCGGAATTAATTCGAT
GAAACTCTCTGCTAGTGGGAGTGATTCTACTACAGTAGAGGGAATGGGATTTGCAATTCCTTCAAATGAAGTAGTAACCA
TTATTGATCAACTGGTTAAGAATGGTAAAATCACACGTCCTGCGCTGGGTGTCGCTTTAGTCGATTTGACCCAAGTTTCA
TCTACACAGCAAAAATCAATCCTTAAACTACCTTCTAATGTAACGGACGGGACCGTATTGATGCAAGTTAATAATGGTCC
AGCCAAAACAGCAGGTTTGAAGAAATACGATGTTATTACTAAGATTGATGATAAGGCAATTACTGATACAGCCGGACTTC
GTGAGGCACTATACAAGCACAAGATTAATGATAAAATCACGGTGGGCTATTATCGTGATGGCAAGTATAAAACAACAGTA
GTGACATTGACTAAGACAAGTACAACAACATCATCTACTACTACAAAATAA

Upstream 100 bases:

>100_bases
ATTTTTGAGGACTAAATTCACATAACCATCGTATTTACCATGTACAATAAATTTAAAATAAATTTTGTATGAGGGGGGAG
CGGGAAATCCGCGCATTCTT

Downstream 100 bases:

>100_bases
AAAAGCTGGAGCATCTAGGTGAAATTAACCAACCTAAAATGCTTCCAGCTTTTTATTTTTGACGGCGCAACAAACGATAT
CCGGTGATTAGGGTAGCAAT

Product: trypsin-like serine protease

Products: NA

Alternate protein names: HtrALl [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKTNKLVIVAAIAGLLGGGVAYGGASFIHNQMESSSTAVPTGSNTTGTTKTSNVKVNVSSQSSKAFSTIKDSVVSVINLQ
KANTNDSDSIISSIFGNESSSSSKSSSSSSELETASEGSGVIYKKSGDTAYIVTNNHVVSGSSSLEIIMSNGKKLPAKIV
GTDSVTDLAVLKINSSAVTTVASFGNSDNIKVGETALAIGSPLGSEYATSLTQGIISAKKRTVETTTENGQNNGEATVIQ
TDAAINAGNSGGPLINLAGQVIGINSMKLSASGSDSTTVEGMGFAIPSNEVVTIIDQLVKNGKITRPALGVALVDLTQVS
STQQKSILKLPSNVTDGTVLMQVNNGPAKTAGLKKYDVITKIDDKAITDTAGLREALYKHKINDKITVGYYRDGKYKTTV
VTLTKTSTTTSSTTTK

Sequences:

>Translated_416_residues
MKTNKLVIVAAIAGLLGGGVAYGGASFIHNQMESSSTAVPTGSNTTGTTKTSNVKVNVSSQSSKAFSTIKDSVVSVINLQ
KANTNDSDSIISSIFGNESSSSSKSSSSSSELETASEGSGVIYKKSGDTAYIVTNNHVVSGSSSLEIIMSNGKKLPAKIV
GTDSVTDLAVLKINSSAVTTVASFGNSDNIKVGETALAIGSPLGSEYATSLTQGIISAKKRTVETTTENGQNNGEATVIQ
TDAAINAGNSGGPLINLAGQVIGINSMKLSASGSDSTTVEGMGFAIPSNEVVTIIDQLVKNGKITRPALGVALVDLTQVS
STQQKSILKLPSNVTDGTVLMQVNNGPAKTAGLKKYDVITKIDDKAITDTAGLREALYKHKINDKITVGYYRDGKYKTTV
VTLTKTSTTTSSTTTK
>Mature_416_residues
MKTNKLVIVAAIAGLLGGGVAYGGASFIHNQMESSSTAVPTGSNTTGTTKTSNVKVNVSSQSSKAFSTIKDSVVSVINLQ
KANTNDSDSIISSIFGNESSSSSKSSSSSSELETASEGSGVIYKKSGDTAYIVTNNHVVSGSSSLEIIMSNGKKLPAKIV
GTDSVTDLAVLKINSSAVTTVASFGNSDNIKVGETALAIGSPLGSEYATSLTQGIISAKKRTVETTTENGQNNGEATVIQ
TDAAINAGNSGGPLINLAGQVIGINSMKLSASGSDSTTVEGMGFAIPSNEVVTIIDQLVKNGKITRPALGVALVDLTQVS
STQQKSILKLPSNVTDGTVLMQVNNGPAKTAGLKKYDVITKIDDKAITDTAGLREALYKHKINDKITVGYYRDGKYKTTV
VTLTKTSTTTSSTTTK

Specific function: Degrades abnormal exported proteins. Needed for the propeptide processing of a natural pro-protein and for the maturation of a native protein. Responsible for the housekeeping of exported proteins [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=274, Percent_Identity=34.6715328467153, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4506141, Length=270, Percent_Identity=35.1851851851852, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI22129776, Length=273, Percent_Identity=32.967032967033, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI7019477, Length=271, Percent_Identity=32.4723247232472, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI1786356, Length=291, Percent_Identity=37.8006872852234, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1789630, Length=306, Percent_Identity=33.6601307189542, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789629, Length=289, Percent_Identity=36.6782006920415, Blast_Score=148, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24646839, Length=277, Percent_Identity=35.0180505415162, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42772; Mature: 42772

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNKLVIVAAIAGLLGGGVAYGGASFIHNQMESSSTAVPTGSNTTGTTKTSNVKVNVSS
CCCCCEEEHHHHHHHHCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCEECCEEEEEECC
QSSKAFSTIKDSVVSVINLQKANTNDSDSIISSIFGNESSSSSKSSSSSSELETASEGSG
CCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCC
VIYKKSGDTAYIVTNNHVVSGSSSLEIIMSNGKKLPAKIVGTDSVTDLAVLKINSSAVTT
EEEEECCCEEEEEECCEEECCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEECCCCEEE
VASFGNSDNIKVGETALAIGSPLGSEYATSLTQGIISAKKRTVETTTENGQNNGEATVIQ
HHHCCCCCCEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEE
TDAAINAGNSGGPLINLAGQVIGINSMKLSASGSDSTTVEGMGFAIPSNEVVTIIDQLVK
ECCEEECCCCCCCEEEECCEEEEEEEEEEECCCCCCCEECCEEEECCCCHHHHHHHHHHH
NGKITRPALGVALVDLTQVSSTQQKSILKLPSNVTDGTVLMQVNNGPAKTAGLKKYDVIT
CCCCCCCHHCEEEEEHHHHCCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEE
KIDDKAITDTAGLREALYKHKINDKITVGYYRDGKYKTTVVTLTKTSTTTSSTTTK
ECCCCHHCCHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKTNKLVIVAAIAGLLGGGVAYGGASFIHNQMESSSTAVPTGSNTTGTTKTSNVKVNVSS
CCCCCEEEHHHHHHHHCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCEECCEEEEEECC
QSSKAFSTIKDSVVSVINLQKANTNDSDSIISSIFGNESSSSSKSSSSSSELETASEGSG
CCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCC
VIYKKSGDTAYIVTNNHVVSGSSSLEIIMSNGKKLPAKIVGTDSVTDLAVLKINSSAVTT
EEEEECCCEEEEEECCEEECCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEECCCCEEE
VASFGNSDNIKVGETALAIGSPLGSEYATSLTQGIISAKKRTVETTTENGQNNGEATVIQ
HHHCCCCCCEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEE
TDAAINAGNSGGPLINLAGQVIGINSMKLSASGSDSTTVEGMGFAIPSNEVVTIIDQLVK
ECCEEECCCCCCCEEEECCEEEEEEEEEEECCCCCCCEECCEEEECCCCHHHHHHHHHHH
NGKITRPALGVALVDLTQVSSTQQKSILKLPSNVTDGTVLMQVNNGPAKTAGLKKYDVIT
CCCCCCCHHCEEEEEHHHHCCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEE
KIDDKAITDTAGLREALYKHKINDKITVGYYRDGKYKTTVVTLTKTSTTTSSTTTK
ECCCCHHCCHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10712686; 11337471 [H]