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The map label for this gene is uvrC

Identifier: 116492896

GI number: 116492896

Start: 1134348

End: 1136132

Strand: Reverse

Name: uvrC

Synonym: PEPE_1135

Alternate gene names: 116492896

Gene position: 1136132-1134348 (Counterclockwise)

Preceding gene: 116492897

Following gene: 116492895

Centisome position: 62.0

GC content: 37.03

Gene sequence:

>1785_bases
TTGGCATCAGAACACATTGAACATAAGTTGGCATTGTTACCAGATAAACCAGGCTGTTACCAGATGAAAAATCTTAATAG
CCAAATCATTTACGTTGGAAAAGCCAAAAACTTGAAAAACCGTGTTCGCTCTTACTTTAAAAGTAGCCATGAGGGAAAAA
CGGCGAAACTAGTGAGTGAAATAGCCGATTTTGACTATATTGTTACCTCTAGCGATAAAGAAGCTTTTTTACTAGAAATT
ACTTTAATTCAAAAGTTCCAACCTTATTACAATATAAAATTGAAAAAAGGGACTGGCTATCCTTATATTAAAATTACGAA
TGAAAAAGATCCACGAATGGAAATTGTTTCAAGTGTTCGTCGAGATGGGGGCTTTTACTTTGGACCTTATCCAAACGTGT
ATGCTGCTGAAGAAACACTCCATTTTTTGGAAAAGGTTTATCCACTACGCCGATGCAATGGATTTCAGGGTCGCCCCTGC
TTGTACTATCATATGGGGCAATGCTTGGGAGCCTGTTTCCAAGAGGTACCCAAAGAAGAATACGACCAACAAATCGCTAA
AATTAAATCATTTTTACGAGGAAATGTCGCAAAGATTAAGCAGTCCCTTCAAACAAAAATGCAAAAAGCTTCTGAAGCAA
TGGAATTTGAACGGGCAGCCGACATACGAGATCAAATTCATTATATTGAAGTAACGGTTGAGAAGCAGAAGATTATTTCA
AATGATAGCACGCCACGTGATTTGTTTAATTTCTACCTTGATAAGGGGTGGCTTTCTATTCAAATCTTCTTTATCCGGCA
ATCACGCTTGATTAAACGAGAGAAGAGGCTATTTCCAATCGCAACAGATGTAAATGATGAGCTTTCGTCTTTTATTCTTC
AATTTTATAATAATAAAAATAAGGTTTTACCAAATGAAATTTTAGTACCAAGTGGCTTAGATAATAAGATTATGGCCGAA
ATTTTAGGTGTCCCGGTTCGCACTCCACAGCGTGGGGAAAAGAAAAACTTGTTAGAGTTAGCTAAAGAAAATGCACAAAT
TACCCTTGAGGAAAAGTTCCGATTAATGGAGTTAGATGAAAGTAAAACAACAGGCGCAATGAAGGAAATTACTGATGCGC
TTGGAATCCCTGAAGGTCATCGAATTGAAGCCTTTGACCATTCTCATATTCAAGGCTCTGAATTAGTTTCAGCAATGGTT
GTTTTTACGGATGGAAAACCAGATAAAAAGATGTATCGCAAATTTAAGCTAAATACAGTCGATCATGCTGATGAAGCTGC
CAGTACGAGAGAGGTAATTCGTCGCCGATATGTTAGACTATTAAAAGAGAAACAATCTTTGCCTGATTTGATTTTAATGG
ACGGTGGCGATATTCAGCTTAATGCAGCAAAGGATGTTTTGGTAAATGAATTAAGTTTGCATATTCCAGTTGCTGGGATG
GTTAAAAATGATAAACATAAAACTTCGGATTTGATTTTTGGTAGCCAAGACCAACGAGTACAGTTGGATCCTAAAAGTCA
GGGCTTTTATTTAGTTCAAAGAATCCAAGATGAAGTGCATCGTTTTGCGATTACTTTCCATCGTCAGTTGCACGCCAAAA
ATTCGTTGGCTTCCCAATTAGATTTAATTCAAGGTGTTGGACCTAAAACGCGGAACAAGCTGTTGAAGTCGTTTGGTTCA
TTGAATAAAATTAGGGATGCTAATTTGAAAGAAATTGAAGAACTCGGAATTCCAGAAAAAGTAGCTAAAACTATCAAAGT
GTCCTTATCAGTGCACGGAAAATAG

Upstream 100 bases:

>100_bases
AGAGTGTAATACTACTACCTGTTTTTTCGTTTTAGTTGCTGAATATGGTAAAAACAGAGTATAATGTTATGAGTTATTAT
GTAAACTAGGAGGGGTCAAA

Downstream 100 bases:

>100_bases
GGTACACTAACAAATGGATAGGAATTTCTCGGTGAAATAAAATATTTAGGAGAAAATAATGTTTGTAGATCAAGTTAAAA
TTAATGTTAAAGCTGGTAAC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MASEHIEHKLALLPDKPGCYQMKNLNSQIIYVGKAKNLKNRVRSYFKSSHEGKTAKLVSEIADFDYIVTSSDKEAFLLEI
TLIQKFQPYYNIKLKKGTGYPYIKITNEKDPRMEIVSSVRRDGGFYFGPYPNVYAAEETLHFLEKVYPLRRCNGFQGRPC
LYYHMGQCLGACFQEVPKEEYDQQIAKIKSFLRGNVAKIKQSLQTKMQKASEAMEFERAADIRDQIHYIEVTVEKQKIIS
NDSTPRDLFNFYLDKGWLSIQIFFIRQSRLIKREKRLFPIATDVNDELSSFILQFYNNKNKVLPNEILVPSGLDNKIMAE
ILGVPVRTPQRGEKKNLLELAKENAQITLEEKFRLMELDESKTTGAMKEITDALGIPEGHRIEAFDHSHIQGSELVSAMV
VFTDGKPDKKMYRKFKLNTVDHADEAASTREVIRRRYVRLLKEKQSLPDLILMDGGDIQLNAAKDVLVNELSLHIPVAGM
VKNDKHKTSDLIFGSQDQRVQLDPKSQGFYLVQRIQDEVHRFAITFHRQLHAKNSLASQLDLIQGVGPKTRNKLLKSFGS
LNKIRDANLKEIEELGIPEKVAKTIKVSLSVHGK

Sequences:

>Translated_594_residues
MASEHIEHKLALLPDKPGCYQMKNLNSQIIYVGKAKNLKNRVRSYFKSSHEGKTAKLVSEIADFDYIVTSSDKEAFLLEI
TLIQKFQPYYNIKLKKGTGYPYIKITNEKDPRMEIVSSVRRDGGFYFGPYPNVYAAEETLHFLEKVYPLRRCNGFQGRPC
LYYHMGQCLGACFQEVPKEEYDQQIAKIKSFLRGNVAKIKQSLQTKMQKASEAMEFERAADIRDQIHYIEVTVEKQKIIS
NDSTPRDLFNFYLDKGWLSIQIFFIRQSRLIKREKRLFPIATDVNDELSSFILQFYNNKNKVLPNEILVPSGLDNKIMAE
ILGVPVRTPQRGEKKNLLELAKENAQITLEEKFRLMELDESKTTGAMKEITDALGIPEGHRIEAFDHSHIQGSELVSAMV
VFTDGKPDKKMYRKFKLNTVDHADEAASTREVIRRRYVRLLKEKQSLPDLILMDGGDIQLNAAKDVLVNELSLHIPVAGM
VKNDKHKTSDLIFGSQDQRVQLDPKSQGFYLVQRIQDEVHRFAITFHRQLHAKNSLASQLDLIQGVGPKTRNKLLKSFGS
LNKIRDANLKEIEELGIPEKVAKTIKVSLSVHGK
>Mature_593_residues
ASEHIEHKLALLPDKPGCYQMKNLNSQIIYVGKAKNLKNRVRSYFKSSHEGKTAKLVSEIADFDYIVTSSDKEAFLLEIT
LIQKFQPYYNIKLKKGTGYPYIKITNEKDPRMEIVSSVRRDGGFYFGPYPNVYAAEETLHFLEKVYPLRRCNGFQGRPCL
YYHMGQCLGACFQEVPKEEYDQQIAKIKSFLRGNVAKIKQSLQTKMQKASEAMEFERAADIRDQIHYIEVTVEKQKIISN
DSTPRDLFNFYLDKGWLSIQIFFIRQSRLIKREKRLFPIATDVNDELSSFILQFYNNKNKVLPNEILVPSGLDNKIMAEI
LGVPVRTPQRGEKKNLLELAKENAQITLEEKFRLMELDESKTTGAMKEITDALGIPEGHRIEAFDHSHIQGSELVSAMVV
FTDGKPDKKMYRKFKLNTVDHADEAASTREVIRRRYVRLLKEKQSLPDLILMDGGDIQLNAAKDVLVNELSLHIPVAGMV
KNDKHKTSDLIFGSQDQRVQLDPKSQGFYLVQRIQDEVHRFAITFHRQLHAKNSLASQLDLIQGVGPKTRNKLLKSFGSL
NKIRDANLKEIEELGIPEKVAKTIKVSLSVHGK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=605, Percent_Identity=35.3719008264463, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1788037, Length=189, Percent_Identity=28.042328042328, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_PEDPA (Q03F33)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804631.1
- ProteinModelPortal:   Q03F33
- STRING:   Q03F33
- GeneID:   4417104
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1135
- NMPDR:   fig|278197.10.peg.996
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q03F33
- ProtClustDB:   PRK00558
- BioCyc:   PPEN278197:PEPE_1135-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68087; Mature: 67955

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEHIEHKLALLPDKPGCYQMKNLNSQIIYVGKAKNLKNRVRSYFKSSHEGKTAKLVSE
CCCHHHHHHHEECCCCCCCCHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHH
IADFDYIVTSSDKEAFLLEITLIQKFQPYYNIKLKKGTGYPYIKITNEKDPRMEIVSSVR
HHCCCEEEECCCCCEEEEEEHHHHHCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHH
RDGGFYFGPYPNVYAAEETLHFLEKVYPLRRCNGFQGRPCLYYHMGQCLGACFQEVPKEE
HCCCEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHH
YDQQIAKIKSFLRGNVAKIKQSLQTKMQKASEAMEFERAADIRDQIHYIEVTVEKQKIIS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEHHHHHC
NDSTPRDLFNFYLDKGWLSIQIFFIRQSRLIKREKRLFPIATDVNDELSSFILQFYNNKN
CCCCHHHHHHHHHCCCEEEEEEEEEEHHHHHHHHHCCCCEECCCCHHHHHHHHHHHCCCC
KVLPNEILVPSGLDNKIMAEILGVPVRTPQRGEKKNLLELAKENAQITLEEKFRLMELDE
CCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEHHCEEEEECCC
SKTTGAMKEITDALGIPEGHRIEAFDHSHIQGSELVSAMVVFTDGKPDKKMYRKFKLNTV
CCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHEEEEEEECCCCCHHHHHHHCCCCC
DHADEAASTREVIRRRYVRLLKEKQSLPDLILMDGGDIQLNAAKDVLVNELSLHIPVAGM
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECHHHHHHHHHHEECCCHHH
VKNDKHKTSDLIFGSQDQRVQLDPKSQGFYLVQRIQDEVHRFAITFHRQLHAKNSLASQL
CCCCCCCCHHCEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIQGVGPKTRNKLLKSFGSLNKIRDANLKEIEELGIPEKVAKTIKVSLSVHGK
HHHHCCCCHHHHHHHHHHCCHHHHCCCCHHHHHHCCCCHHHHHHEEEEEEECCC
>Mature Secondary Structure 
ASEHIEHKLALLPDKPGCYQMKNLNSQIIYVGKAKNLKNRVRSYFKSSHEGKTAKLVSE
CCHHHHHHHEECCCCCCCCHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHH
IADFDYIVTSSDKEAFLLEITLIQKFQPYYNIKLKKGTGYPYIKITNEKDPRMEIVSSVR
HHCCCEEEECCCCCEEEEEEHHHHHCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHH
RDGGFYFGPYPNVYAAEETLHFLEKVYPLRRCNGFQGRPCLYYHMGQCLGACFQEVPKEE
HCCCEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHH
YDQQIAKIKSFLRGNVAKIKQSLQTKMQKASEAMEFERAADIRDQIHYIEVTVEKQKIIS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEHHHHHC
NDSTPRDLFNFYLDKGWLSIQIFFIRQSRLIKREKRLFPIATDVNDELSSFILQFYNNKN
CCCCHHHHHHHHHCCCEEEEEEEEEEHHHHHHHHHCCCCEECCCCHHHHHHHHHHHCCCC
KVLPNEILVPSGLDNKIMAEILGVPVRTPQRGEKKNLLELAKENAQITLEEKFRLMELDE
CCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEHHCEEEEECCC
SKTTGAMKEITDALGIPEGHRIEAFDHSHIQGSELVSAMVVFTDGKPDKKMYRKFKLNTV
CCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHEEEEEEECCCCCHHHHHHHCCCCC
DHADEAASTREVIRRRYVRLLKEKQSLPDLILMDGGDIQLNAAKDVLVNELSLHIPVAGM
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECHHHHHHHHHHEECCCHHH
VKNDKHKTSDLIFGSQDQRVQLDPKSQGFYLVQRIQDEVHRFAITFHRQLHAKNSLASQL
CCCCCCCCHHCEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIQGVGPKTRNKLLKSFGSLNKIRDANLKEIEELGIPEKVAKTIKVSLSVHGK
HHHHCCCCHHHHHHHHHHCCHHHHCCCCHHHHHHCCCCHHHHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA