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The map label for this gene is recS [H]

Identifier: 116492844

GI number: 116492844

Start: 1078457

End: 1079881

Strand: Reverse

Name: recS [H]

Synonym: PEPE_1082

Alternate gene names: 116492844

Gene position: 1079881-1078457 (Counterclockwise)

Preceding gene: 116492845

Following gene: 116492843

Centisome position: 58.93

GC content: 34.6

Gene sequence:

>1425_bases
ATGGTAACAGATAAAAAAATTTATCAAGTCTTACATGAGAAATTTAATTTTACTGAGTTTAAAACGGGTCAGTTAGAAAT
TTTACATAAACTTTTTGACCATCACCATACATTGGCGATTTTACCAACAGGAGCTGGAAAAACCTTAATTTATCAAATGT
ATGGTTTTTTAAATGAGGGCTCCGTTATTGTGGTTTCGCCTTTATTATCCTTGATTAAAGACCAAATCAACCGGTTAAGA
TTAAGTGGGGAACGTCGTATAGCAGAGATAACTTCTCAAATAGATTTTATGGAGCAAAAGCAAATCCTTAACAATTTAGA
AAGATATAAATTTATTTTTATATCACCTGAGGGATTGCAGCGACCTGATGTTCAAGCAGCGATGCAACGAATAGAGATCG
ACTTATTTGTAGTTGATGAAGCTCATTGTATCGTTCAATGGGGGAAGTCGTTTCGTCCAGACTACTTAAAAATTGGTCGG
ATACGAACGCAATTAAACAACCCCCTAACATTGATGTTAACGGCCACAGCTGGAAAAACAACCCGTGAAGAAATCGTTAG
GTACCTTAATTTGAAAAAAGGTGAGGTTGAAGAATATATTAGTTCTGTCGATCGCTCCAATATCTATCTTGATTTTTTAG
AAGTCGAAAGTAGAAGTGACAAAGATGAAAAACTTTTAGATTTACTTGATGAGTTACCAGGGGCAGGAATAATCTACTTT
TCAAGTCGCAAAGTTGCTAGCCAAGTTAGCGAAATGATTAATAATAATCTTACTCTTACTTCGGCTCCATATCATGCAGG
GATGACAGACTATGACCGTTTTCAAGTTCAAAAACAGTTTCAACAAGATCAAGTCAATGTGATTTGTGCTACCAGTGCGT
TTGGAATGGGTATTGATAAAGCTAATATCAGATATGTAATTCACTATCATTTGCCCGGAGACATTGAAAGTTATGTCCAA
GAGATCGGTCGTGCTGGTCGCGATGGTCAACAGAGTATTGCTATTATGTTGTATGCGGCTGGCGACGAGGTAATTCCTTC
AATTTTAAATGATATTGAAATTCCTTCTGAAGCAATCCTTACTGAAAATCTTGAACGCAGTGGTATAGATGAAGAGCAGC
AAGAATTAATTAAATATTATCAAGAAAATGGGCTAACCCCTCACGAATTAACAGAGTTATTTAAAAGACAACAATTACAA
AATGAACAGCAAATCTTAAGAATGTTAAAACTCATTCGAACGGAGAATTGTCATCGTCAATATTTGCTACAATATTTTGA
TGAGGGCTTCAAAAAACACCATGATTTATGTTGTGGTTCAATCAATACTTTCGAAGAATTAAAGTTAGAAGCTAATTTAA
CAACTAAAAAAATGCAAATTGAACCTTGGAAATCAAGATTAAATAAAATTTTTGCAGGAATATAG

Upstream 100 bases:

>100_bases
GAAGTTGACTTTAGAAGTATCCAAAGCCAAATTGCAGATATTACATTTTTTGATTTTAGGCTAATCCAAATCAGAAAAAT
TAAGGAACAACAGAATAATA

Downstream 100 bases:

>100_bases
CGTAATTTTCGTGGTCATTCAAATTGAATTATTGTAAAATACAATTTATTGGTATGTAGTAGGAGGATAAACATGAACGA
GAAAAATGATGAGAACTTAA

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: Recombination protein S [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MVTDKKIYQVLHEKFNFTEFKTGQLEILHKLFDHHHTLAILPTGAGKTLIYQMYGFLNEGSVIVVSPLLSLIKDQINRLR
LSGERRIAEITSQIDFMEQKQILNNLERYKFIFISPEGLQRPDVQAAMQRIEIDLFVVDEAHCIVQWGKSFRPDYLKIGR
IRTQLNNPLTLMLTATAGKTTREEIVRYLNLKKGEVEEYISSVDRSNIYLDFLEVESRSDKDEKLLDLLDELPGAGIIYF
SSRKVASQVSEMINNNLTLTSAPYHAGMTDYDRFQVQKQFQQDQVNVICATSAFGMGIDKANIRYVIHYHLPGDIESYVQ
EIGRAGRDGQQSIAIMLYAAGDEVIPSILNDIEIPSEAILTENLERSGIDEEQQELIKYYQENGLTPHELTELFKRQQLQ
NEQQILRMLKLIRTENCHRQYLLQYFDEGFKKHHDLCCGSINTFEELKLEANLTTKKMQIEPWKSRLNKIFAGI

Sequences:

>Translated_474_residues
MVTDKKIYQVLHEKFNFTEFKTGQLEILHKLFDHHHTLAILPTGAGKTLIYQMYGFLNEGSVIVVSPLLSLIKDQINRLR
LSGERRIAEITSQIDFMEQKQILNNLERYKFIFISPEGLQRPDVQAAMQRIEIDLFVVDEAHCIVQWGKSFRPDYLKIGR
IRTQLNNPLTLMLTATAGKTTREEIVRYLNLKKGEVEEYISSVDRSNIYLDFLEVESRSDKDEKLLDLLDELPGAGIIYF
SSRKVASQVSEMINNNLTLTSAPYHAGMTDYDRFQVQKQFQQDQVNVICATSAFGMGIDKANIRYVIHYHLPGDIESYVQ
EIGRAGRDGQQSIAIMLYAAGDEVIPSILNDIEIPSEAILTENLERSGIDEEQQELIKYYQENGLTPHELTELFKRQQLQ
NEQQILRMLKLIRTENCHRQYLLQYFDEGFKKHHDLCCGSINTFEELKLEANLTTKKMQIEPWKSRLNKIFAGI
>Mature_474_residues
MVTDKKIYQVLHEKFNFTEFKTGQLEILHKLFDHHHTLAILPTGAGKTLIYQMYGFLNEGSVIVVSPLLSLIKDQINRLR
LSGERRIAEITSQIDFMEQKQILNNLERYKFIFISPEGLQRPDVQAAMQRIEIDLFVVDEAHCIVQWGKSFRPDYLKIGR
IRTQLNNPLTLMLTATAGKTTREEIVRYLNLKKGEVEEYISSVDRSNIYLDFLEVESRSDKDEKLLDLLDELPGAGIIYF
SSRKVASQVSEMINNNLTLTSAPYHAGMTDYDRFQVQKQFQQDQVNVICATSAFGMGIDKANIRYVIHYHLPGDIESYVQ
EIGRAGRDGQQSIAIMLYAAGDEVIPSILNDIEIPSEAILTENLERSGIDEEQQELIKYYQENGLTPHELTELFKRQQLQ
NEQQILRMLKLIRTENCHRQYLLQYFDEGFKKHHDLCCGSINTFEELKLEANLTTKKMQIEPWKSRLNKIFAGI

Specific function: Probable DNA helicase. Required in synaptic and/or post- synaptic stages of recombination. Probably has overlapping function with recQ (AC O34748). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=358, Percent_Identity=34.9162011173184, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI51242943, Length=358, Percent_Identity=34.9162011173184, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI148612816, Length=358, Percent_Identity=35.195530726257, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI110735439, Length=347, Percent_Identity=37.1757925072046, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI169218196, Length=347, Percent_Identity=37.1757925072046, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI4557365, Length=353, Percent_Identity=32.8611898016997, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI14591902, Length=353, Percent_Identity=31.1614730878187, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI14591904, Length=353, Percent_Identity=31.1614730878187, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI284005309, Length=359, Percent_Identity=32.3119777158774, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI21040371, Length=160, Percent_Identity=30.625, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI7661920, Length=144, Percent_Identity=31.9444444444444, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI87196351, Length=255, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI301171475, Length=255, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI301171467, Length=255, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4758112, Length=160, Percent_Identity=28.125, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI18375623, Length=160, Percent_Identity=28.125, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI169881239, Length=255, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI13514809, Length=255, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI188035877, Length=317, Percent_Identity=22.7129337539432, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI48994977, Length=336, Percent_Identity=37.5, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1788930, Length=335, Percent_Identity=22.9850746268657, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25145561, Length=360, Percent_Identity=36.3888888888889, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI32564293, Length=447, Percent_Identity=32.4384787472036, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17552866, Length=425, Percent_Identity=29.8823529411765, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71987997, Length=348, Percent_Identity=32.183908045977, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71987993, Length=348, Percent_Identity=32.183908045977, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71995724, Length=144, Percent_Identity=34.0277777777778, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507121, Length=144, Percent_Identity=34.0277777777778, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71995514, Length=275, Percent_Identity=26.5454545454545, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17510307, Length=275, Percent_Identity=26.5454545454545, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17510309, Length=275, Percent_Identity=26.5454545454545, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI86570094, Length=350, Percent_Identity=24.5714285714286, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71982858, Length=242, Percent_Identity=26.0330578512397, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=466, Percent_Identity=31.7596566523605, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6325138, Length=237, Percent_Identity=29.1139240506329, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324778, Length=213, Percent_Identity=27.2300469483568, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324217, Length=331, Percent_Identity=25.3776435045317, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321360, Length=366, Percent_Identity=22.6775956284153, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320224, Length=229, Percent_Identity=25.3275109170306, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320119, Length=346, Percent_Identity=23.6994219653179, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646066, Length=353, Percent_Identity=37.6770538243626, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24664226, Length=375, Percent_Identity=32, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI62472181, Length=375, Percent_Identity=32, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24664230, Length=375, Percent_Identity=32, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI21358123, Length=362, Percent_Identity=33.7016574585635, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24645031, Length=144, Percent_Identity=34.0277777777778, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581954, Length=244, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581952, Length=244, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581956, Length=244, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17985987, Length=248, Percent_Identity=28.2258064516129, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24666101, Length=347, Percent_Identity=23.9193083573487, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355075, Length=367, Percent_Identity=24.7956403269755, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR002464
- InterPro:   IPR004589
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 54793; Mature: 54793

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTDKKIYQVLHEKFNFTEFKTGQLEILHKLFDHHHTLAILPTGAGKTLIYQMYGFLNEG
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCC
SVIVVSPLLSLIKDQINRLRLSGERRIAEITSQIDFMEQKQILNNLERYKFIFISPEGLQ
CEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCC
RPDVQAAMQRIEIDLFVVDEAHCIVQWGKSFRPDYLKIGRIRTQLNNPLTLMLTATAGKT
CCCHHHHHHHHEEEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
TREEIVRYLNLKKGEVEEYISSVDRSNIYLDFLEVESRSDKDEKLLDLLDELPGAGIIYF
HHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEE
SSRKVASQVSEMINNNLTLTSAPYHAGMTDYDRFQVQKQFQQDQVNVICATSAFGMGIDK
CCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
ANIRYVIHYHLPGDIESYVQEIGRAGRDGQQSIAIMLYAAGDEVIPSILNDIEIPSEAIL
CCEEEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCHHHH
TENLERSGIDEEQQELIKYYQENGLTPHELTELFKRQQLQNEQQILRMLKLIRTENCHRQ
HHCHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHH
YLLQYFDEGFKKHHDLCCGSINTFEELKLEANLTTKKMQIEPWKSRLNKIFAGI
HHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCEEECCHHHHHHHHHHHCC
>Mature Secondary Structure
MVTDKKIYQVLHEKFNFTEFKTGQLEILHKLFDHHHTLAILPTGAGKTLIYQMYGFLNEG
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCC
SVIVVSPLLSLIKDQINRLRLSGERRIAEITSQIDFMEQKQILNNLERYKFIFISPEGLQ
CEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCC
RPDVQAAMQRIEIDLFVVDEAHCIVQWGKSFRPDYLKIGRIRTQLNNPLTLMLTATAGKT
CCCHHHHHHHHEEEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
TREEIVRYLNLKKGEVEEYISSVDRSNIYLDFLEVESRSDKDEKLLDLLDELPGAGIIYF
HHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEE
SSRKVASQVSEMINNNLTLTSAPYHAGMTDYDRFQVQKQFQQDQVNVICATSAFGMGIDK
CCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
ANIRYVIHYHLPGDIESYVQEIGRAGRDGQQSIAIMLYAAGDEVIPSILNDIEIPSEAIL
CCEEEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCHHHH
TENLERSGIDEEQQELIKYYQENGLTPHELTELFKRQQLQNEQQILRMLKLIRTENCHRQ
HHCHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHH
YLLQYFDEGFKKHHDLCCGSINTFEELKLEANLTTKKMQIEPWKSRLNKIFAGI
HHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 9642195 [H]