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The map label for this gene is lexA

Identifier: 116492636

GI number: 116492636

Start: 872021

End: 872650

Strand: Reverse

Name: lexA

Synonym: PEPE_0870

Alternate gene names: 116492636

Gene position: 872650-872021 (Counterclockwise)

Preceding gene: 116492639

Following gene: 116492635

Centisome position: 47.62

GC content: 38.41

Gene sequence:

>630_bases
ATGGCAAAAAATATCAGCACTAAGCAACTCAGCGTTCTGGAATATATTTATAAAACAGTTAACGCTCAAGGATATCCACC
TACAGTGCGTGAAATTGGTAGTGCCATTGGACTATCATCTACTTCCACTGTTCATGGACACATTGATCGTTTACAAAAAA
ACGGCTTTTTAGAAAAGGATCCTACTAAGCCCCGAGCTTTAGAGGTAACAAAATTAGGTTTAGACGCTTTAGGAGTACAA
GATAAAAATCCTACTATTCCCTTACTGGGAGTAGTTACTGCCGGTGAACCAATTTTGGCTGTTGAAGAAGCTACAGATTT
CTTCCCTGTTCCTCCAGAGTACGAAAATGATAGTAGTAATTTGTTCATGCTTACCATCCGAGGAGAAAGTATGATTAATG
CCGGTATTTTATCTGGTGATCAAGTTATTGTTAGAAAACAATCTACAGCCGACAATGGCACCATTGTAATTGCTATGACT
GATGAAAATGAAGCAACTTGCAAACGATTCTATCGAGAATCCGATCACATTCGACTTCAACCAGAAAATGATACGATGGC
CCCAATTATTTTGGACAACGTGACTATCCTCGGTAAAGTTGTTGGTTTATTTAGAGATAACATCTACTAG

Upstream 100 bases:

>100_bases
ACTATGGAAAGCTTTTAATTTCAATTTTTAAGGCGAACATTTGTTTGAGTATTAGGATTTTTTATGATAAAATAACAACA
AATATTTATGAGGTGAAAAA

Downstream 100 bases:

>100_bases
ATGTGACTTTCCTATTGATTTATTATGTTTTTCAAAGCATACTATTGTTAATGCGATAAATCATTTTGGAGGGTTACTAT
GCTTTACGTTTTAGTTTTAG

Product: XRE family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MAKNISTKQLSVLEYIYKTVNAQGYPPTVREIGSAIGLSSTSTVHGHIDRLQKNGFLEKDPTKPRALEVTKLGLDALGVQ
DKNPTIPLLGVVTAGEPILAVEEATDFFPVPPEYENDSSNLFMLTIRGESMINAGILSGDQVIVRKQSTADNGTIVIAMT
DENEATCKRFYRESDHIRLQPENDTMAPIILDNVTILGKVVGLFRDNIY

Sequences:

>Translated_209_residues
MAKNISTKQLSVLEYIYKTVNAQGYPPTVREIGSAIGLSSTSTVHGHIDRLQKNGFLEKDPTKPRALEVTKLGLDALGVQ
DKNPTIPLLGVVTAGEPILAVEEATDFFPVPPEYENDSSNLFMLTIRGESMINAGILSGDQVIVRKQSTADNGTIVIAMT
DENEATCKRFYRESDHIRLQPENDTMAPIILDNVTILGKVVGLFRDNIY
>Mature_208_residues
AKNISTKQLSVLEYIYKTVNAQGYPPTVREIGSAIGLSSTSTVHGHIDRLQKNGFLEKDPTKPRALEVTKLGLDALGVQD
KNPTIPLLGVVTAGEPILAVEEATDFFPVPPEYENDSSNLFMLTIRGESMINAGILSGDQVIVRKQSTADNGTIVIAMTD
ENEATCKRFYRESDHIRLQPENDTMAPIILDNVTILGKVVGLFRDNIY

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=211, Percent_Identity=29.8578199052133, Blast_Score=103, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_PEDPA (Q03FU3)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804371.1
- ProteinModelPortal:   Q03FU3
- SMR:   Q03FU3
- STRING:   Q03FU3
- MEROPS:   S24.001
- GeneID:   4418176
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0870
- NMPDR:   fig|278197.10.peg.773
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- OMA:   VIAMTDE
- PhylomeDB:   Q03FU3
- BioCyc:   PPEN278197:PEPE_0870-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 22918; Mature: 22787

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: ACT_SITE 130-130 ACT_SITE 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNISTKQLSVLEYIYKTVNAQGYPPTVREIGSAIGLSSTSTVHGHIDRLQKNGFLEKD
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC
PTKPRALEVTKLGLDALGVQDKNPTIPLLGVVTAGEPILAVEEATDFFPVPPEYENDSSN
CCCCCEEEEEEECHHHCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCC
LFMLTIRGESMINAGILSGDQVIVRKQSTADNGTIVIAMTDENEATCKRFYRESDHIRLQ
EEEEEECCCCEEECEECCCCEEEEEECCCCCCCEEEEEEECCCHHHHHHHHCCCCCEEEC
PENDTMAPIILDNVTILGKVVGLFRDNIY
CCCCCCCEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKNISTKQLSVLEYIYKTVNAQGYPPTVREIGSAIGLSSTSTVHGHIDRLQKNGFLEKD
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC
PTKPRALEVTKLGLDALGVQDKNPTIPLLGVVTAGEPILAVEEATDFFPVPPEYENDSSN
CCCCCEEEEEEECHHHCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCC
LFMLTIRGESMINAGILSGDQVIVRKQSTADNGTIVIAMTDENEATCKRFYRESDHIRLQ
EEEEEECCCCEEECEECCCCEEEEEECCCCCCCEEEEEEECCCHHHHHHHHCCCCCEEEC
PENDTMAPIILDNVTILGKVVGLFRDNIY
CCCCCCCEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA