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The map label for this gene is qor [C]

Identifier: 116492470

GI number: 116492470

Start: 742852

End: 743778

Strand: Reverse

Name: qor [C]

Synonym: PEPE_0702

Alternate gene names: 116492470

Gene position: 743778-742852 (Counterclockwise)

Preceding gene: 116492484

Following gene: 116492451

Centisome position: 40.59

GC content: 38.3

Gene sequence:

>927_bases
ATGAAAGCAATCGGTGTTAATCAATTTGGTAATATTTCAGATTTAATTGAACTAGACGTTCCAAAGCCAGAGCCTTCCAG
TGGACGCCTTATTGTTCAAACCAAAGCTTTTGCACTAAACCCATATGATTTAGGAATTATTGATGGTACTCAAGCCAAGT
TTCGCCCAATTTCACTGCCAGCCATTCCAGGTAGTGATGTTGCAGGTATCATCGTGGACAAAGACCCCTCCATTACCGAA
TTCAACCTTTGTGATTCAATTGTGGGATTGGCTAACCTCAAAGGTTATAGCGAATATGTTTCAGTTCCTTATCGTCGAGC
AACTAAACTTCCTGCCGAAATCAGTTATCGGACGGCTGCAGGTCTTCCCAACGCAGGTATCACTGCGTATGATATCGTTT
TTGGAGCATTAAAAGACGTTTCGTTTTCAAAAGTGCTCATTATTGGTGCCTCTGGAGCGGTAGGAACTAACTTGTATCAA
ATTTTAAATAGTTTAAATAAGCAAGTTTCCGTTGTAATTAACTCCAAGTATACTGAACAATTTGATACTGCAGATTTTAA
TCAAGTTGTTTTTTACGATGCTCCAAAAACAATTGAGCAACTAGGTCTTTATGACGTAATTATTAACGTTGCGCCACAAA
ATGAGCTGGCCGACCTTTACTTAGCCCACCTTGCTCCATCTGGTTTATTGATTTCTACAACTGGGATTGACACCTTCAAA
ACTGACCCATCAAGATTAGTTGATTTTTACAACACAGATTACAAAATGAACCAAGCCGCTTTAGAATATCTTGTTAAAAA
AGTTGTAAGTCAAGAAATAACCGTCCCGATTGCCGAAATCTTAAATTTTGATGTAGCTGAAATTCAAAAAGCTTTTCATG
CTCTTCAAACGCATCATCCGAGAGGGAAATATATCGTTGAAGTTTAA

Upstream 100 bases:

>100_bases
TAGTAGACTCTTTTGGAAAGAGAGCAACCTATACTTGCAAGCTTAAATCTTTTATTTCACTTAACTTTATATTATGTTTA
GTACAAGAGGTGATTATATT

Downstream 100 bases:

>100_bases
TTAACGTTCAGAAAATAAATAAAAAGGATTGGTTCCAAAACTCATTGTTTTGTTCCAATCCTTTTTATTTATTAATTCAT
TTAATCTAATAGATTAAAGA

Product: NADPH:quinone reductase related Zn-dependent oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: Oxidoreductase; Alcohol Dehydrogenase GroES Domain Protein; Alcohol Dehydrogenase GroES Domain-Containing Protein; NADPHQuinone Reductase; Zinc-Containing Alcohol Dehydrogenase; Dehydrogenase; Quinone Oxidoreductase; Alcohol Dehydrogenase Zinc-Containing; Alcohol Dehydrogenase Zinc-Dependent; NADPHQuinone Reductase Related Zn-Dependent Oxidoreductase; NADPH-Quinone Reductase; NADPHQuinone Reductase-Like Zn-Dependent Oxidoreductase; Zinc-Containing Alcohol Dehydrogenase Superfamily Protein; Oxidoreductase Protein; Alcohol Dehydrogenase GroES-Like Domain Family; Quinone Reductase; NADPH2Quinone Reductase; Zinc-Containing Alcohol Dehydrogenase Superfamily; Zinc-Type Alcohol Dehydrogenase; Zn-Dependent Oxidoreductase; Alginate Lyase; Alcohol Dehydrogenase Zinc Containing Protein; Zinc-Dependent Oxidoreductase; NAD(P)H Quinone Oxidoreductase PIG3 Family; Zinc-Type Alcohol Dehydrogenase-Like Protein; Alcohol Dehydrogenase GroES-Like Protein; NADPH-Quinone Alcohol Dehydrogenase Zn-Dependent; Orf_Bo; NADPH Quinone Oxidoreductase; Quinone Oxidoreductase-Like Protein; Zn-Dependent Oxidoreductase NADPHQuinone Reductase

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKAIGVNQFGNISDLIELDVPKPEPSSGRLIVQTKAFALNPYDLGIIDGTQAKFRPISLPAIPGSDVAGIIVDKDPSITE
FNLCDSIVGLANLKGYSEYVSVPYRRATKLPAEISYRTAAGLPNAGITAYDIVFGALKDVSFSKVLIIGASGAVGTNLYQ
ILNSLNKQVSVVINSKYTEQFDTADFNQVVFYDAPKTIEQLGLYDVIINVAPQNELADLYLAHLAPSGLLISTTGIDTFK
TDPSRLVDFYNTDYKMNQAALEYLVKKVVSQEITVPIAEILNFDVAEIQKAFHALQTHHPRGKYIVEV

Sequences:

>Translated_308_residues
MKAIGVNQFGNISDLIELDVPKPEPSSGRLIVQTKAFALNPYDLGIIDGTQAKFRPISLPAIPGSDVAGIIVDKDPSITE
FNLCDSIVGLANLKGYSEYVSVPYRRATKLPAEISYRTAAGLPNAGITAYDIVFGALKDVSFSKVLIIGASGAVGTNLYQ
ILNSLNKQVSVVINSKYTEQFDTADFNQVVFYDAPKTIEQLGLYDVIINVAPQNELADLYLAHLAPSGLLISTTGIDTFK
TDPSRLVDFYNTDYKMNQAALEYLVKKVVSQEITVPIAEILNFDVAEIQKAFHALQTHHPRGKYIVEV
>Mature_308_residues
MKAIGVNQFGNISDLIELDVPKPEPSSGRLIVQTKAFALNPYDLGIIDGTQAKFRPISLPAIPGSDVAGIIVDKDPSITE
FNLCDSIVGLANLKGYSEYVSVPYRRATKLPAEISYRTAAGLPNAGITAYDIVFGALKDVSFSKVLIIGASGAVGTNLYQ
ILNSLNKQVSVVINSKYTEQFDTADFNQVVFYDAPKTIEQLGLYDVIINVAPQNELADLYLAHLAPSGLLISTTGIDTFK
TDPSRLVDFYNTDYKMNQAALEYLVKKVVSQEITVPIAEILNFDVAEIQKAFHALQTHHPRGKYIVEV

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24308257, Length=165, Percent_Identity=27.8787878787879, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI194239676, Length=229, Percent_Identity=25.764192139738, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI194239674, Length=255, Percent_Identity=25.8823529411765, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI13236495, Length=255, Percent_Identity=25.8823529411765, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 33591; Mature: 33591

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIGVNQFGNISDLIELDVPKPEPSSGRLIVQTKAFALNPYDLGIIDGTQAKFRPISLP
CCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEEEEECCEEEEEEECCCCCEEEEECC
AIPGSDVAGIIVDKDPSITEFNLCDSIVGLANLKGYSEYVSVPYRRATKLPAEISYRTAA
CCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCCCCCCCHHHC
GLPNAGITAYDIVFGALKDVSFSKVLIIGASGAVGTNLYQILNSLNKQVSVVINSKYTEQ
CCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
FDTADFNQVVFYDAPKTIEQLGLYDVIINVAPQNELADLYLAHLAPSGLLISTTGIDTFK
CCCCCCCEEEEECCCHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCC
TDPSRLVDFYNTDYKMNQAALEYLVKKVVSQEITVPIAEILNFDVAEIQKAFHALQTHHP
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHCCCC
RGKYIVEV
CCCEEEEC
>Mature Secondary Structure
MKAIGVNQFGNISDLIELDVPKPEPSSGRLIVQTKAFALNPYDLGIIDGTQAKFRPISLP
CCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEEEEECCEEEEEEECCCCCEEEEECC
AIPGSDVAGIIVDKDPSITEFNLCDSIVGLANLKGYSEYVSVPYRRATKLPAEISYRTAA
CCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCCCCCCCHHHC
GLPNAGITAYDIVFGALKDVSFSKVLIIGASGAVGTNLYQILNSLNKQVSVVINSKYTEQ
CCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
FDTADFNQVVFYDAPKTIEQLGLYDVIINVAPQNELADLYLAHLAPSGLLISTTGIDTFK
CCCCCCCEEEEECCCHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCC
TDPSRLVDFYNTDYKMNQAALEYLVKKVVSQEITVPIAEILNFDVAEIQKAFHALQTHHP
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHCCCC
RGKYIVEV
CCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA