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The map label for this gene is murB

Identifier: 116492276

GI number: 116492276

Start: 525479

End: 526381

Strand: Direct

Name: murB

Synonym: PEPE_0474

Alternate gene names: 116492276

Gene position: 525479-526381 (Clockwise)

Preceding gene: 116492275

Following gene: 116492277

Centisome position: 28.68

GC content: 42.86

Gene sequence:

>903_bases
ATGATGGATCAATCAATAGCTGATGCATTTCCAGAGGTTCAAGTGTTAGAGCATGAGCCTTTGTCAAAATACACCAATAC
CCAAACTGGTGGTCCAGCTGATTTGTTGGTATTTCCAGAGTCAGTAACAGAAACCAAACGACTAGTACTTTGGGCAAAAG
AAACGGATACGCCATTGACCATTATTGGTAATGCAAGTAATTTAATTGTGCGAGATGGTGGTATTCGAGGGTTAACGTTA
ATTTTAACTAAAATGGATGACATCCAGGTCAATGGAAATGAAGTTGTTGCGGAAGCAGGGGCGGCACTGATTCAGACCAC
GGAAGTAGCCTACCAAGCAGGATTAACGGGCCTTGAATTTGCAGCTGGTATTCCTGGATCAATCGGGGGCGCAGTCTTTA
TGAATGCGGGTGCCTATGATGGTGAGATTAGTGAAGTAGTTACTAGCGCAGAAATTTTGACGAGAGATGGCGAGATTAAA
AATTTAAATAACCATGAACTCGATTTCGGTTACCGCCATAGTAGTGTGCAAGATTATCAAGATGTTGTGCTTTCGGCAAC
CTTTAAGTTACGTTCAGGGGATGCTAACAAAATTCGAGCTCGGATGGACGAACTGAATCGTTTGCGAGCTTCGAAACAAC
CTCTTGAATATCCATCATGTGGGAGTGTTTTTAAACGACCAACAGGCTACTTTACTGGAAAATTAATTCATGAGGCAGGT
CTTCAAGGCTTTACAGTGGGGGGCGCACAGGTTTCAATGAAACATGCGGGCTTCATCATTAACGTTGGAGGAGCCACCGC
AACAGATTACATGGATGTGATTCATCATGTTCAAGCAACCGTCTTGAAACAATTTGGAGTAACGCTAGAAACCGAAGTTC
GAATTATCGGTGAAGAGAAATAA

Upstream 100 bases:

>100_bases
TCCTTTCACACGAGTTGTGCGCGCGTTTAATAAGCCAAGGTAAAGTGATAGAATAGACTAAGAGATTTTAAGATGAAAAG
AAAAAGTAAGAGGGGAAAGT

Downstream 100 bases:

>100_bases
TTAATTGGTATATATTAGAAGAGTTTAGAAAAATAATTTGATTTTCTAAACTCTTCTTTGTTCGAAAAGACCATAAAGAA
CGGCAGGTCCATGGTATAAT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MMDQSIADAFPEVQVLEHEPLSKYTNTQTGGPADLLVFPESVTETKRLVLWAKETDTPLTIIGNASNLIVRDGGIRGLTL
ILTKMDDIQVNGNEVVAEAGAALIQTTEVAYQAGLTGLEFAAGIPGSIGGAVFMNAGAYDGEISEVVTSAEILTRDGEIK
NLNNHELDFGYRHSSVQDYQDVVLSATFKLRSGDANKIRARMDELNRLRASKQPLEYPSCGSVFKRPTGYFTGKLIHEAG
LQGFTVGGAQVSMKHAGFIINVGGATATDYMDVIHHVQATVLKQFGVTLETEVRIIGEEK

Sequences:

>Translated_300_residues
MMDQSIADAFPEVQVLEHEPLSKYTNTQTGGPADLLVFPESVTETKRLVLWAKETDTPLTIIGNASNLIVRDGGIRGLTL
ILTKMDDIQVNGNEVVAEAGAALIQTTEVAYQAGLTGLEFAAGIPGSIGGAVFMNAGAYDGEISEVVTSAEILTRDGEIK
NLNNHELDFGYRHSSVQDYQDVVLSATFKLRSGDANKIRARMDELNRLRASKQPLEYPSCGSVFKRPTGYFTGKLIHEAG
LQGFTVGGAQVSMKHAGFIINVGGATATDYMDVIHHVQATVLKQFGVTLETEVRIIGEEK
>Mature_300_residues
MMDQSIADAFPEVQVLEHEPLSKYTNTQTGGPADLLVFPESVTETKRLVLWAKETDTPLTIIGNASNLIVRDGGIRGLTL
ILTKMDDIQVNGNEVVAEAGAALIQTTEVAYQAGLTGLEFAAGIPGSIGGAVFMNAGAYDGEISEVVTSAEILTRDGEIK
NLNNHELDFGYRHSSVQDYQDVVLSATFKLRSGDANKIRARMDELNRLRASKQPLEYPSCGSVFKRPTGYFTGKLIHEAG
LQGFTVGGAQVSMKHAGFIINVGGATATDYMDVIHHVQATVLKQFGVTLETEVRIIGEEK

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_PEDPA (Q03GV3)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804011.1
- ProteinModelPortal:   Q03GV3
- SMR:   Q03GV3
- STRING:   Q03GV3
- GeneID:   4418337
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0474
- NMPDR:   fig|278197.10.peg.441
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- PhylomeDB:   Q03GV3
- ProtClustDB:   PRK13905
- BioCyc:   PPEN278197:PEPE_0474-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32346; Mature: 32346

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 172-172 ACT_SITE 222-222 ACT_SITE 292-292

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDQSIADAFPEVQVLEHEPLSKYTNTQTGGPADLLVFPESVTETKRLVLWAKETDTPLT
CCCCHHHHHCCCEEEECCCCHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCEE
IIGNASNLIVRDGGIRGLTLILTKMDDIQVNGNEVVAEAGAALIQTTEVAYQAGLTGLEF
EEECCCEEEEECCCCCEEEEEEEECCCEEECCCCHHHHHCHHHHHHHHHHHHHCCCHHHH
AAGIPGSIGGAVFMNAGAYDGEISEVVTSAEILTRDGEIKNLNNHELDFGYRHSSVQDYQ
HCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
DVVLSATFKLRSGDANKIRARMDELNRLRASKQPLEYPSCGSVFKRPTGYFTGKLIHEAG
HHHHHEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHCC
LQGFTVGGAQVSMKHAGFIINVGGATATDYMDVIHHVQATVLKQFGVTLETEVRIIGEEK
CCEEEECCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCC
>Mature Secondary Structure
MMDQSIADAFPEVQVLEHEPLSKYTNTQTGGPADLLVFPESVTETKRLVLWAKETDTPLT
CCCCHHHHHCCCEEEECCCCHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCEE
IIGNASNLIVRDGGIRGLTLILTKMDDIQVNGNEVVAEAGAALIQTTEVAYQAGLTGLEF
EEECCCEEEEECCCCCEEEEEEEECCCEEECCCCHHHHHCHHHHHHHHHHHHHCCCHHHH
AAGIPGSIGGAVFMNAGAYDGEISEVVTSAEILTRDGEIKNLNNHELDFGYRHSSVQDYQ
HCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
DVVLSATFKLRSGDANKIRARMDELNRLRASKQPLEYPSCGSVFKRPTGYFTGKLIHEAG
HHHHHEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHCC
LQGFTVGGAQVSMKHAGFIINVGGATATDYMDVIHHVQATVLKQFGVTLETEVRIIGEEK
CCEEEECCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA