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The map label for this gene is pyrD

Identifier: 116492120

GI number: 116492120

Start: 363540

End: 364454

Strand: Direct

Name: pyrD

Synonym: PEPE_0317

Alternate gene names: 116492120

Gene position: 363540-364454 (Clockwise)

Preceding gene: 116492119

Following gene: 116492121

Centisome position: 19.84

GC content: 43.93

Gene sequence:

>915_bases
ATGGATCGCTTAGAAACGACAATTGCTGGAGTCAAGTTAAAAAGCCCGGTTATGAATGCTAGTGGGACGGCTGCATATGG
ACAACAAATGGCTAAAAATATTGATTTAAATGAACTGGGAGCATTCGTAATTAAGTCGACAACTATGGAGCCGCGTGCAG
GCCATCCGTGGCCAACTACTGCGGCCACCACTGGAGGCTGGCTGAATGCGGTCGGTTTGAAGAATCCTGGTATTGAACAT
GTTTTAGCTTACGAACTCCCTTGGTTAGCTGAAAATTATCCGGATCTTCCCATTGTTGGAAGTATTGCTGGTTCTAATCC
GGATGATTATGTTGAAGTAGCTAAACGCATGGCGACCGCCCCGAATGTGAAGTTCATTGAAGTTAATATTTCATGTCCTA
ATGTTGCTAAAGGTGGTCTGGCATTTGGTACTGATCCAGTTGTAGTTGAAGATATGACCCGGCGCATCAAAGCGGTAGTT
CCTAATAAACCCGTCTTCATGAAGTTAACCCCGGGAGTAACTGAAATTGTTCCCATTGCTTTAGCTGCTGAACGGGGCGG
TGCAGATGGCTTAGTAATGATAAATACCTTAATGGGAATGGAAATTGATTTAGAAACTAGAAAGCCACGTCTTTCCAATG
GGACGGGCGGTCTTTCCGGAAAAGCGATTCATCCCATCGCAGTTCGCATGATTCATCAAGTACGCGAAGTAACTAATTTA
CCAATTATTGGGGTTGGAGGGGTATTTTCTGCTAAAGATGCGTTAGAATTAATGGTAGCTGGAGCAGGGGCTGTTCAAGT
TGGATCAGCAAATTATGGTAATCCACATGCTTGCCACGACATTATTCAAGGCTTAGTTCCAGCAATGGATCAATATCACT
TTAACAACATTGCGGAGTTTAGCTCCGAGAAATAA

Upstream 100 bases:

>100_bases
ATGGAGTACCACTTTTTACGGCATTAGATACCGTTGACGCTATTTTACAAGTGCTTGAATCACAAGCTTTTACAACATTA
CATCTTTAGGAGGAAAACAA

Downstream 100 bases:

>100_bases
GCGGAGGTTTAGTAGTGACTGAACGAGTAGAATTTAAACCAACAAGTATTGATGATTTAAGTAGCCAATATGATGTAATT
ATTATCGGAGCTGGGAGTAC

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MDRLETTIAGVKLKSPVMNASGTAAYGQQMAKNIDLNELGAFVIKSTTMEPRAGHPWPTTAATTGGWLNAVGLKNPGIEH
VLAYELPWLAENYPDLPIVGSIAGSNPDDYVEVAKRMATAPNVKFIEVNISCPNVAKGGLAFGTDPVVVEDMTRRIKAVV
PNKPVFMKLTPGVTEIVPIALAAERGGADGLVMINTLMGMEIDLETRKPRLSNGTGGLSGKAIHPIAVRMIHQVREVTNL
PIIGVGGVFSAKDALELMVAGAGAVQVGSANYGNPHACHDIIQGLVPAMDQYHFNNIAEFSSEK

Sequences:

>Translated_304_residues
MDRLETTIAGVKLKSPVMNASGTAAYGQQMAKNIDLNELGAFVIKSTTMEPRAGHPWPTTAATTGGWLNAVGLKNPGIEH
VLAYELPWLAENYPDLPIVGSIAGSNPDDYVEVAKRMATAPNVKFIEVNISCPNVAKGGLAFGTDPVVVEDMTRRIKAVV
PNKPVFMKLTPGVTEIVPIALAAERGGADGLVMINTLMGMEIDLETRKPRLSNGTGGLSGKAIHPIAVRMIHQVREVTNL
PIIGVGGVFSAKDALELMVAGAGAVQVGSANYGNPHACHDIIQGLVPAMDQYHFNNIAEFSSEK
>Mature_304_residues
MDRLETTIAGVKLKSPVMNASGTAAYGQQMAKNIDLNELGAFVIKSTTMEPRAGHPWPTTAATTGGWLNAVGLKNPGIEH
VLAYELPWLAENYPDLPIVGSIAGSNPDDYVEVAKRMATAPNVKFIEVNISCPNVAKGGLAFGTDPVVVEDMTRRIKAVV
PNKPVFMKLTPGVTEIVPIALAAERGGADGLVMINTLMGMEIDLETRKPRLSNGTGGLSGKAIHPIAVRMIHQVREVTNL
PIIGVGGVFSAKDALELMVAGAGAVQVGSANYGNPHACHDIIQGLVPAMDQYHFNNIAEFSSEK

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=194, Percent_Identity=39.1752577319588, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI45006951, Length=293, Percent_Identity=30.3754266211604, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87082059, Length=318, Percent_Identity=32.3899371069182, Blast_Score=124, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71984108, Length=286, Percent_Identity=30.4195804195804, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17509475, Length=321, Percent_Identity=26.791277258567, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322633, Length=279, Percent_Identity=31.1827956989247, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24640763, Length=194, Percent_Identity=39.1752577319588, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI18858217, Length=194, Percent_Identity=39.1752577319588, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI281361352, Length=322, Percent_Identity=29.1925465838509, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137316, Length=322, Percent_Identity=29.1925465838509, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_PEDPA (Q03HA9)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_803855.1
- ProteinModelPortal:   Q03HA9
- SMR:   Q03HA9
- STRING:   Q03HA9
- GeneID:   4418493
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0317
- NMPDR:   fig|278197.10.peg.292
- eggNOG:   COG0167
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- PhylomeDB:   Q03HA9
- ProtClustDB:   PRK07259
- BioCyc:   PPEN278197:PEPE_0317-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32172; Mature: 32172

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLETTIAGVKLKSPVMNASGTAAYGQQMAKNIDLNELGAFVIKSTTMEPRAGHPWPTT
CCHHHHHHHCEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHEEEEECCCCCCCCCCCCCC
AATTGGWLNAVGLKNPGIEHVLAYELPWLAENYPDLPIVGSIAGSNPDDYVEVAKRMATA
CCCCCCCEEECCCCCCCHHHEEEECCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHCC
PNVKFIEVNISCPNVAKGGLAFGTDPVVVEDMTRRIKAVVPNKPVFMKLTPGVTEIVPIA
CCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHEEE
LAAERGGADGLVMINTLMGMEIDLETRKPRLSNGTGGLSGKAIHPIAVRMIHQVREVTNL
EEECCCCCCCEEEEEEHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
PIIGVGGVFSAKDALELMVAGAGAVQVGSANYGNPHACHDIIQGLVPAMDQYHFNNIAEF
CEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
SSEK
CCCC
>Mature Secondary Structure
MDRLETTIAGVKLKSPVMNASGTAAYGQQMAKNIDLNELGAFVIKSTTMEPRAGHPWPTT
CCHHHHHHHCEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHEEEEECCCCCCCCCCCCCC
AATTGGWLNAVGLKNPGIEHVLAYELPWLAENYPDLPIVGSIAGSNPDDYVEVAKRMATA
CCCCCCCEEECCCCCCCHHHEEEECCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHCC
PNVKFIEVNISCPNVAKGGLAFGTDPVVVEDMTRRIKAVVPNKPVFMKLTPGVTEIVPIA
CCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHEEE
LAAERGGADGLVMINTLMGMEIDLETRKPRLSNGTGGLSGKAIHPIAVRMIHQVREVTNL
EEECCCCCCCEEEEEEHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
PIIGVGGVFSAKDALELMVAGAGAVQVGSANYGNPHACHDIIQGLVPAMDQYHFNNIAEF
CEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
SSEK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA